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WEN Lu, OUYANG Hui, YUAN Hao, TIAN Jing, ZHANG Fang. Application of B-type brain natriuretic peptide in patients with acute exacerbation of chronic obstructive pulmonary disease with left ventricular ejection fraction retention[J]. Journal of Clinical Medicine in Practice, 2022, 26(24): 46-50. DOI: 10.7619/jcmp.20222662
Citation: WEN Lu, OUYANG Hui, YUAN Hao, TIAN Jing, ZHANG Fang. Application of B-type brain natriuretic peptide in patients with acute exacerbation of chronic obstructive pulmonary disease with left ventricular ejection fraction retention[J]. Journal of Clinical Medicine in Practice, 2022, 26(24): 46-50. DOI: 10.7619/jcmp.20222662
shu

Application of B-type brain natriuretic peptide in patients with acute exacerbation of chronic obstructive pulmonary disease with left ventricular ejection fraction retention

  • 1.

    Department of Respiratory and Critical Care Medicine, the Fourth Hospital of Changsha in Hunan Province, Changsha, Hunan, 410000

  • 2.

    Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Air Force Military Medical University of the Chinese People's Liberation Army, Xi'an, Shaanxi 710032

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  • Received Date: August 25, 2022
  • Available Online: January 06, 2023
    Graphical Abstract
    • Abstract
  • Objective 

    To analyze the correlations of serum B-type brain natriuretic peptide (BNP) with arterial partial pressure of oxygen[pa(O2)], high-sensitivity C-reactive protein (hs-CRP), right ventricular end diastolic diameter (RVDD) and death in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and left ventricular ejection function (LVEF) preservation.

    Methods 

    The data of 150 AECOPD patients with LVEF preservation were retrospectively analyzed. According to the serum BNP level, they were divided into group A (BNP ≤ 100 pg/mL, n=82), group B (BNP>100 pg/mL to 400 pg/mL, n=45) and group C (BNP>400 pg/mL, n=23). The pa(O2), BNP, hs-CRP and RVDD were compared among the three groups after admission. The correlations of BNP with pa(O2), hs-CRP as well as RVDD were analyzed; predictors of death within 1 year were analyzed by Logistic regression. The 1 year mortality risk ratio (RR) of the 3 groups was analyzed.

    Results 

    The pa(O2) in group B and group C was significantly lower than that in group A, and BNP, hs-CRP and RVDD were higher than those in group A (P < 0.05). BNP and hs-CRP in group C were significantly higher than those in group B (P < 0.05). Correlation analysis showed that BNP was negatively correlated with pa(O2) (r=-0.385, P < 0.001), but positively correlated with hs-CRP and RVDD (r=0.664, 0.388, P < 0.001). Within 1 year, the RR and 95%CI of group C with group A and group B were 1.303(1.019 to 1.668) and 1.263(0.978 to 1.630), respectively, and the differences were statistically significant (P < 0.05). BNP was an independent predicting factor for death within 1 year (P < 0.05).

    Conclusion 

    The elevated BNP level in AECOPD patients with LVEF preservation is associated with decreased pa(O2) level, increased hs-CRP, and increased RVDD. Serum BNP is a sensitive indicator for assessing the condition of AECOPD and death.

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    • References (18)
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