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XU Peirong, ZHANG Yan, SUN Qiannan, WANG Daorong. The mediating effect of cancer-induced fatigue on sleep and cognitive function after gastrointestinal tumor surgery[J]. Journal of Clinical Medicine in Practice, 2023, 27(2): 73-77. DOI: 10.7619/jcmp.20223117
Citation: XU Peirong, ZHANG Yan, SUN Qiannan, WANG Daorong. The mediating effect of cancer-induced fatigue on sleep and cognitive function after gastrointestinal tumor surgery[J]. Journal of Clinical Medicine in Practice, 2023, 27(2): 73-77. DOI: 10.7619/jcmp.20223117
shu

The mediating effect of cancer-induced fatigue on sleep and cognitive function after gastrointestinal tumor surgery

  • 1.

    School of Nursing, School of Public Health of Yangzhou University, Yangzhou, Jiangsu, 225009

  • 2.

    Northern Jiangsu People′s Hospital of Jiangsu Province, Yangzhou, Jiangsu, 225003

  • 3.

    General Surgery Institute of Yangzhou, Yangzhou University, Yangzhou, Jiangsu, 225003

  • 4.

    Medical College of Yangzhou University, Yangzhou, Jiangsu, 225009

More Information
  • Received Date: October 14, 2022
  • Available Online: February 16, 2023
    Graphical Abstract
    • Abstract
  • Objective 

    To investigate the mediating effect of cancerous fatigue between sleep and cognitive function in patients after gastrointestinal tumor surgery.

    Methods 

    A total of 314 patients with gastrointestinal cancer were selected as study objects. Cancer-related Fatigue Scale, Pittsburgh Sleep Quality Index Scale and Cancer Treatment Function Evaluation-Cognitive Function Scale were used to evaluate the patients′ cancer-related fatigue score, sleep score and cognitive function score, respectively. Pearson correlation analysis was used to explore the relationships among cancer-induced fatigue, sleep and cognitive function, and maximum likelihood method was used to build a structural equation model and verify it, and the mediating effect of cancer-induced fatigue on sleep and cognitive function were analyzed.

    Results 

    The score of cancer fatigue, sleep score and cognitive function score were (10.07±6.69), (7.46±3.99) and (97.13±25.40), respectively. Correlation analysis showed that cancer fatigue score was positively correlated with sleep score (r=0.308, P < 0.001), was negatively correlated with cognitive function score (r=-0.432, P < 0.001). Sleep score was negatively correlated with cognitive function score (r=-0.269, P < 0.001). The results of the mediating effect test showed that cancer-related fatigue had a partial mediating effect between sleep and cognitive function (explanatory variance ratio was 22.44%).

    Conclusion 

    There are close relationships among cancerous fatigue, cognitive function and sleep, and sleep can directly or indirectly affect cognitive function through cancer-related fatigue. Medical staff should pay attention to sleep and fatigue in patients with gastrointestinal tumor to reduce the incidence of cognitive impairment.

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    • References (26)
  • [1]
    ABRAHAM E H, KHAN B, LING E, et al. The development and evaluation of a patient educational resource for cancer-related cognitive dysfunction[J]. J Cancer Educ, 2022, 37(1): 111-119. doi: 10.1007/s13187-020-01793-3
    [2]
    JANELSINS M C, LEI L L, NETHERBY-WINSLOW C, et al. Relationships between cytokines and cognitive function from pre- to post-chemotherapy in patients with breast cancer[J]. J Neuroimmunol, 2022, 362: 577769. doi: 10.1016/j.jneuroim.2021.577769
    [3]
    PERGOLOTTI M, BATTISTI N M L, PADGETT L, et al. Embracing the complexity: older adults with cancer-related cognitive decline-a Young International Society of Geriatric Oncology position paper[J]. J Geriatr Oncol, 2020, 11(2): 237-243. doi: 10.1016/j.jgo.2019.09.002
    [4]
    SCHMIDT M E, HERMANN S, ARNDT V, et al. Prevalence and severity of long-term physical, emotional, and cognitive fatigue across 15 different cancer entities[J]. Cancer Med, 2020, 9(21): 8053-8061. doi: 10.1002/cam4.3413
    [5]
    胡保玲. 乳腺癌患者癌因性疲乏风险预测模型的构建与验证[D]. 福州: 福建中医药大学, 2022.
    [6]
    WANG Z, CHEN W H, LI S X, et al. Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation[J]. Mol Psychiatry, 2021, 26(11): 6277-6292. doi: 10.1038/s41380-021-01113-1
    [7]
    李春丽. 睡眠障碍患者匹兹堡睡眠质量指数、心率变异性与冠心病的相关性研究[D]. 石家庄: 河北医科大学, 2020.
    [8]
    郤丽娟, 王道荣, 方方, 等. 抑郁在老年胃肠肿瘤患者睡眠与术前衰弱间的中介效应[J]. 实用临床医药杂志, 2021, 25(5): 50-54. doi: 10.7619/jcmp.20201747
    [9]
    向玉云. 乳腺癌患者治疗期认知障碍发展轨迹及其适应方式的纵向研究[D]. 成都: 电子科技大学, 2022.
    [10]
    高文秀, 孙玉倩, 杨芳. 乳腺癌病人化疗期认知障碍和觉知压力的相关性研究[J]. 护理研究, 2020, 34(9): 1618-1621. https://www.cnki.com.cn/Article/CJFDTOTAL-SXHZ202009028.htm
    [11]
    CHEUNG Y T, SHWE M, CHUI W K, et al. Effects of chemotherapy and psychosocial distress on perceived cognitive disturbances in Asian breast cancer patients[J]. Ann Pharmacother, 2012, 46(12): 1645-1655. doi: 10.1345/aph.1R408
    [12]
    USLU A, CANBOLAT O. Relationship between frailty and fatigue in older cancer patients[J]. Semin Oncol Nurs, 2021, 37(4): 151179. doi: 10.1016/j.soncn.2021.151179
    [13]
    JIAN Z H, LI C P, CHIU E C. Ecological, convergent, and discriminative validities of the cognitive abilities screening instrument in people with dementia[J]. Medicine, 2021, 100(11): e25225. doi: 10.1097/MD.0000000000025225
    [14]
    KIM M S, LEE S H, KIM J G. Evaluation of factors affecting arsenic uptake by Brassica juncea in alkali soil after biochar application using partial least squares path modeling (PLS-PM)[J]. Chemosphere, 2021, 275: 130095. doi: 10.1016/j.chemosphere.2021.130095
    [15]
    SHI D X, MAYDEU-OLIVARES A. The effect of estimation methods on SEM fit indices[J]. Educ Psychol Meas, 2020, 80(3): 421-445. doi: 10.1177/0013164419885164
    [16]
    KIRKPATRICK R M, PRITIKIN J N, HUNTER M D, et al. Combining structural-equation modeling with genomic-relatedness-matrix restricted maximum likelihood in OpenMx[J]. Behav Genet, 2021, 51(3): 331-342. doi: 10.1007/s10519-020-10037-5
    [17]
    AL MAQBALI M. Cancer-related fatigue: an overview[J]. Br J Nurs, 2021, 30(4): S36-S43. doi: 10.12968/bjon.2021.30.4.S36
    [18]
    MCDONALD C J, BLANKENHEIM Z J, DREWES L R. Brain endothelial cells: metabolic flux and energy metabolism[J]. Handb Exp Pharmacol, 2022, 273: 59-79.
    [19]
    GLEDHILL J. A qualitative study of the characteristics and representation of fatigue in a French speaking population of cancer patients and healthy subjects[J]. Eur J Oncol Nurs, 2005, 9(4): 294-314. doi: 10.1016/j.ejon.2004.11.002
    [20]
    FOX R S, ANCOLI-ISRAEL S, ROESCH S C, et al. Sleep disturbance and cancer-related fatigue symptom cluster in breast cancer patients undergoing chemotherapy[J]. Support Care Cancer, 2020, 28(2): 845-855. doi: 10.1007/s00520-019-04834-w
    [21]
    MASON G M, LOKHANDWALA S, RIGGINS T, et al. Sleep and human cognitive development[J]. Sleep Med Rev, 2021, 57: 101472. doi: 10.1016/j.smrv.2021.101472
    [22]
    SEWELL K R, ERICKSON K I, RAINEY-SMITH S R, et al. Relationships between physical activity, sleep and cognitive function: a narrative review[J]. Neurosci Biobehav Rev, 2021, 130: 369-378. doi: 10.1016/j.neubiorev.2021.09.003
    [23]
    WALKER W H 2nd, BORNIGER J C. Molecular mechanisms of cancer-induced sleep disruption[J]. Int J Mol Sci, 2019, 20(11): 2780. doi: 10.3390/ijms20112780
    [24]
    CAPPUCCIO F P, D'ELIA L, STRAZZULLO P, et al. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies[J]. Sleep, 2010, 33(5): 585-592. doi: 10.1093/sleep/33.5.585
    [25]
    ORR W C, FASS R, SUNDARAM S S, et al. The effect of sleep on gastrointestinal functioning in common digestive diseases[J]. Lancet Gastroenterol Hepatol, 2020, 5(6): 616-624. doi: 10.1016/S2468-1253(19)30412-1
    [26]
    MOGAVERO M P, DELROSSO L M, FANFULLA F, et al. Sleep disorders and cancer: state of the art and future perspectives[J]. Sleep Med Rev, 2021, 56: 101409. doi: 10.1016/j.smrv.2020.101409
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