The mediating effect of cancer-induced fatigue on sleep and cognitive function after gastrointestinal tumor surgery

XU Peirong; ZHANG Yan; SUN Qiannan; WANG Daorong

doi:10.7619/jcmp.20223117

Journal of Clinical Medicine in Practice > 2023 > 27(2): 73-77. > DOI: 10.7619/jcmp.20223117

XU Peirong, ZHANG Yan, SUN Qiannan, WANG Daorong. The mediating effect of cancer-induced fatigue on sleep and cognitive function after gastrointestinal tumor surgery[J]. Journal of Clinical Medicine in Practice, 2023, 27(2): 73-77. DOI: 10.7619/jcmp.20223117

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The mediating effect of cancer-induced fatigue on sleep and cognitive function after gastrointestinal tumor surgery

XU Peirong¹,
ZHANG Yan¹,
SUN Qiannan^{2, 3},
WANG Daorong^{2, 3, 4, ,}

1.
School of Nursing, School of Public Health of Yangzhou University, Yangzhou, Jiangsu, 225009
2.
Northern Jiangsu People′s Hospital of Jiangsu Province, Yangzhou, Jiangsu, 225003
3.
General Surgery Institute of Yangzhou, Yangzhou University, Yangzhou, Jiangsu, 225003
4.
Medical College of Yangzhou University, Yangzhou, Jiangsu, 225009

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Received Date: October 14, 2022
Available Online: February 16, 2023

Graphical Abstract

Abstract

Abstract

Objective
To investigate the mediating effect of cancerous fatigue between sleep and cognitive function in patients after gastrointestinal tumor surgery.
Methods
A total of 314 patients with gastrointestinal cancer were selected as study objects. Cancer-related Fatigue Scale, Pittsburgh Sleep Quality Index Scale and Cancer Treatment Function Evaluation-Cognitive Function Scale were used to evaluate the patients′ cancer-related fatigue score, sleep score and cognitive function score, respectively. Pearson correlation analysis was used to explore the relationships among cancer-induced fatigue, sleep and cognitive function, and maximum likelihood method was used to build a structural equation model and verify it, and the mediating effect of cancer-induced fatigue on sleep and cognitive function were analyzed.
Results
The score of cancer fatigue, sleep score and cognitive function score were (10.07±6.69), (7.46±3.99) and (97.13±25.40), respectively. Correlation analysis showed that cancer fatigue score was positively correlated with sleep score (r=0.308, P < 0.001), was negatively correlated with cognitive function score (r=-0.432, P < 0.001). Sleep score was negatively correlated with cognitive function score (r=-0.269, P < 0.001). The results of the mediating effect test showed that cancer-related fatigue had a partial mediating effect between sleep and cognitive function (explanatory variance ratio was 22.44%).
Conclusion
There are close relationships among cancerous fatigue, cognitive function and sleep, and sleep can directly or indirectly affect cognitive function through cancer-related fatigue. Medical staff should pay attention to sleep and fatigue in patients with gastrointestinal tumor to reduce the incidence of cognitive impairment.
- cancer-related fatigue,
- sleep,
- cognitive,
- mediating effect,
- gastrointestinal tumor,
- maximum likelihood method,
- structural equation model

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References

[1]	ABRAHAM E H, KHAN B, LING E, et al. The development and evaluation of a patient educational resource for cancer-related cognitive dysfunction[J]. J Cancer Educ, 2022, 37(1): 111-119. doi: 10.1007/s13187-020-01793-3
[2]	JANELSINS M C, LEI L L, NETHERBY-WINSLOW C, et al. Relationships between cytokines and cognitive function from pre- to post-chemotherapy in patients with breast cancer[J]. J Neuroimmunol, 2022, 362: 577769. doi: 10.1016/j.jneuroim.2021.577769
[3]	PERGOLOTTI M, BATTISTI N M L, PADGETT L, et al. Embracing the complexity: older adults with cancer-related cognitive decline-a Young International Society of Geriatric Oncology position paper[J]. J Geriatr Oncol, 2020, 11(2): 237-243. doi: 10.1016/j.jgo.2019.09.002
[4]	SCHMIDT M E, HERMANN S, ARNDT V, et al. Prevalence and severity of long-term physical, emotional, and cognitive fatigue across 15 different cancer entities[J]. Cancer Med, 2020, 9(21): 8053-8061. doi: 10.1002/cam4.3413
[5]	胡保玲. 乳腺癌患者癌因性疲乏风险预测模型的构建与验证[D]. 福州: 福建中医药大学, 2022.
[6]	WANG Z, CHEN W H, LI S X, et al. Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation[J]. Mol Psychiatry, 2021, 26(11): 6277-6292. doi: 10.1038/s41380-021-01113-1
[7]	李春丽. 睡眠障碍患者匹兹堡睡眠质量指数、心率变异性与冠心病的相关性研究[D]. 石家庄: 河北医科大学, 2020.
[8]	郤丽娟, 王道荣, 方方, 等. 抑郁在老年胃肠肿瘤患者睡眠与术前衰弱间的中介效应[J]. 实用临床医药杂志, 2021, 25(5): 50-54. doi: 10.7619/jcmp.20201747
[9]	向玉云. 乳腺癌患者治疗期认知障碍发展轨迹及其适应方式的纵向研究[D]. 成都: 电子科技大学, 2022.
[10]	高文秀, 孙玉倩, 杨芳. 乳腺癌病人化疗期认知障碍和觉知压力的相关性研究[J]. 护理研究, 2020, 34(9): 1618-1621. https://www.cnki.com.cn/Article/CJFDTOTAL-SXHZ202009028.htm
[11]	CHEUNG Y T, SHWE M, CHUI W K, et al. Effects of chemotherapy and psychosocial distress on perceived cognitive disturbances in Asian breast cancer patients[J]. Ann Pharmacother, 2012, 46(12): 1645-1655. doi: 10.1345/aph.1R408
[12]	USLU A, CANBOLAT O. Relationship between frailty and fatigue in older cancer patients[J]. Semin Oncol Nurs, 2021, 37(4): 151179. doi: 10.1016/j.soncn.2021.151179
[13]	JIAN Z H, LI C P, CHIU E C. Ecological, convergent, and discriminative validities of the cognitive abilities screening instrument in people with dementia[J]. Medicine, 2021, 100(11): e25225. doi: 10.1097/MD.0000000000025225
[14]	KIM M S, LEE S H, KIM J G. Evaluation of factors affecting arsenic uptake by Brassica juncea in alkali soil after biochar application using partial least squares path modeling (PLS-PM)[J]. Chemosphere, 2021, 275: 130095. doi: 10.1016/j.chemosphere.2021.130095
[15]	SHI D X, MAYDEU-OLIVARES A. The effect of estimation methods on SEM fit indices[J]. Educ Psychol Meas, 2020, 80(3): 421-445. doi: 10.1177/0013164419885164
[16]	KIRKPATRICK R M, PRITIKIN J N, HUNTER M D, et al. Combining structural-equation modeling with genomic-relatedness-matrix restricted maximum likelihood in OpenMx[J]. Behav Genet, 2021, 51(3): 331-342. doi: 10.1007/s10519-020-10037-5
[17]	AL MAQBALI M. Cancer-related fatigue: an overview[J]. Br J Nurs, 2021, 30(4): S36-S43. doi: 10.12968/bjon.2021.30.4.S36
[18]	MCDONALD C J, BLANKENHEIM Z J, DREWES L R. Brain endothelial cells: metabolic flux and energy metabolism[J]. Handb Exp Pharmacol, 2022, 273: 59-79.
[19]	GLEDHILL J. A qualitative study of the characteristics and representation of fatigue in a French speaking population of cancer patients and healthy subjects[J]. Eur J Oncol Nurs, 2005, 9(4): 294-314. doi: 10.1016/j.ejon.2004.11.002
[20]	FOX R S, ANCOLI-ISRAEL S, ROESCH S C, et al. Sleep disturbance and cancer-related fatigue symptom cluster in breast cancer patients undergoing chemotherapy[J]. Support Care Cancer, 2020, 28(2): 845-855. doi: 10.1007/s00520-019-04834-w
[21]	MASON G M, LOKHANDWALA S, RIGGINS T, et al. Sleep and human cognitive development[J]. Sleep Med Rev, 2021, 57: 101472. doi: 10.1016/j.smrv.2021.101472
[22]	SEWELL K R, ERICKSON K I, RAINEY-SMITH S R, et al. Relationships between physical activity, sleep and cognitive function: a narrative review[J]. Neurosci Biobehav Rev, 2021, 130: 369-378. doi: 10.1016/j.neubiorev.2021.09.003
[23]	WALKER W H 2nd, BORNIGER J C. Molecular mechanisms of cancer-induced sleep disruption[J]. Int J Mol Sci, 2019, 20(11): 2780. doi: 10.3390/ijms20112780
[24]	CAPPUCCIO F P, D'ELIA L, STRAZZULLO P, et al. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies[J]. Sleep, 2010, 33(5): 585-592. doi: 10.1093/sleep/33.5.585
[25]	ORR W C, FASS R, SUNDARAM S S, et al. The effect of sleep on gastrointestinal functioning in common digestive diseases[J]. Lancet Gastroenterol Hepatol, 2020, 5(6): 616-624. doi: 10.1016/S2468-1253(19)30412-1
[26]	MOGAVERO M P, DELROSSO L M, FANFULLA F, et al. Sleep disorders and cancer: state of the art and future perspectives[J]. Sleep Med Rev, 2021, 56: 101409. doi: 10.1016/j.smrv.2020.101409

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