| Citation: |
BAO Yongzheng, ZOU Wenlan, MA Jing, LIU Qian, QIU Yali. Analysis of inflammatory characteristics of air passage and small airway dysfunction in patients with bronchial asthma complicated with allergic rhinitis[J]. Journal of Clinical Medicine in Practice, 2023, 27(1): 49-52. DOI: 10.7619/jcmp.20223259
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To analyze the inflammation characteristics of air passage and small airway dysfunction in patients with asthma complicated with allergic rhinitis.
A total of 96 patients with bronchial asthma were selected as study subjects by cross-sectional study, and were divided into allergic rhinitis-asthma syndrome group (38 cases) and bronchial asthma group (58 cases) according to presence or absence of complicating with allergic rhinitis. Asthma Control Test (ACT) scores were evaluated in both groups. The levels of total immunoglobulin E (IgE), eosinophils (Eos), C-reactive protein (CRP) in peripheral blood, interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-17A (IL-17A), and γ interferon in peripheral blood of patients in two groups were detected. The lung function indicators[percentage of forced expiratory volume in the first second to expected value (FEV1%pred), percentage of forced expiratory flow at 50% of FVC exhaled to expected value (FEF50%pred), maximum mid-expiratory flow to estimated value (MMEF%pred)] were detected. Spearman correlation analysis was used to analyze the correlation between small airway function and airway inflammation.
FEV1%pred, FEF50%pred and MMEF%pred were (55.06±23.12)%, (60.48±21.33)% and (60.34±20.44)% in allergic rhinitis-asthma syndrome group, respectively, which were (69.32±30.63)%, (75.54±26.51)% and (70.26±21.03)%, respectively in the bronchial asthma group (P < 0.05). The levels of total IgE, Eos and CRP in peripheral blood of patients in the allergic rhinitis-asthma syndrome group were higher than those of patients in the bronchial asthma group (P < 0.05). The ACT score of the allergic rhinitis-asthma syndrome group was lower than that of the bronchial asthma group (P < 0.05). The concentrations of serum IL-4 and IL-6 in the allergic rhinitis-asthma syndrome group were higher than those in the asthma group (P < 0.05). However, there were no significant differences in IL-17A and IFN-γ between two groups (P>0.05). Spearman correlation analysis showed that the small airway variables such as MMEF%pred and FEF50%pred in allergic rhinitis-asthma syndrome patients were separately negatively correlated with IL-4 and IL-6, respectively.
Asthma patients complicated with allergic rhinitis have more obvious inflammation and small airway dysfunction than patients with bronchial asthma. Small airway function may be affected by airway inflammation.
| [1] |
LIVA G A, KARATZANIS A D, PROKOPAKIS E P. Review of rhinitis: classification, types, pathophysiology[J]. J Clin Med, 2021, 10(14): 3183. doi: 10.3390/jcm10143183
|
| [2] |
AL HEIALY S, RAMAKRISHNAN R K, HAMID Q. Recent advances in the immunopathogenesis of severe asthma[J]. J Allergy Clin Immunol, 2022, 149(2): 455-465. doi: 10.1016/j.jaci.2021.12.765
|
| [3] |
中华医学会呼吸病学分会哮喘学组. 咳嗽的诊断与治疗指南(2015)[J]. 中华结核和呼吸杂志, 2016, 39(5): 323-354. doi: 10.3760/cma.j.issn.1001-0939.2016.05.003
|
| [4] |
中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 变应性鼻炎诊断和治疗指南(2015年, 天津)[J]. 中华耳鼻咽喉头颈外科杂志, 2016, 51(1): 6-24. doi: 10.3760/cma.j.issn.1673-0860.2016.01.004
|
| [5] |
ANDUJAR-ESPINOSA R, SALINERO-GONZÁLEZ L, ILLÁN-GÓMEZ F, et al. Effect of vitamin D supplementation on asthma control in patients with vitamin D deficiency: the ACVID randomised clinical trial[J]. Thorax, 2021, 76(2): 126-133. doi: 10.1136/thoraxjnl-2019-213936
|
| [6] |
冉启娟, 李芳伟, 万毅新. 电子鼻检测技术在支气管哮喘诊断方面的研究进展[J]. 实用临床医药杂志, 2022, 26(5): 131-134. doi: 10.7619/jcmp.20214415
|
| [7] |
ABDO M. Small airway dysfunction links asthma severity with physical activity and symptom control[J]. J Allergy Clin Immunol Pract, 2021, 9(9): 3359-3368. e1. doi: 10.1016/j.jaip.2021.04.035
|
| [8] |
GROSSMAN J. One airway, one disease[J]. Chest, 1997, 111(2 Suppl): 11S-16S.
|
| [9] |
SOUSA-PINTO B, SÁ-SOUSA A, AMARAL R, et al. Assessment of the control of allergic rhinitis and asthma test (CARAT) using MASK-air[J]. J Allergy Clin Immunol Pract, 2022, 10(1): 343-345. e2. doi: 10.1016/j.jaip.2021.09.012
|
| [10] |
TANG H P, HAN X L, LI T T, et al. Protective effect of miR-138-5p inhibition modified human mesenchymal stem cell on ovalbumin-induced allergic rhinitis and asthma syndrome[J]. J Cell Mol Med, 2021, 25(11): 5038-5049. doi: 10.1111/jcmm.16473
|
| [11] |
NANDA A, MUSTAFA S S, CASTILLO M, et al. Air pollution effects in allergies and asthma[J]. Immunol Allergy Clin North Am, 2022, 42(4): 801-815. doi: 10.1016/j.iac.2022.06.004
|
| [12] |
BROZEK J L, BOUSQUET J, AGACHE I, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision[J]. J Allergy Clin Immunol, 2017, 140(4): 950-958. doi: 10.1016/j.jaci.2017.03.050
|
| [13] |
COTTINI M, LICINI A, LOMBARDI C, et al. Small airway dysfunction and poor asthma control: a dangerous liaison[J]. Clin Mol Allergy, 2021, 19(1): 7. doi: 10.1186/s12948-021-00147-8
|
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