Research progress of endoplasmic reticulum stress in sepsis

SHI Ying; YU Jiangquan; ZHANG Wenjuan

doi:10.7619/jcmp.20230103

Journal of Clinical Medicine in Practice > 2023 > 27(14): 121-125. > DOI: 10.7619/jcmp.20230103

SHI Ying, YU Jiangquan, ZHANG Wenjuan. Research progress of endoplasmic reticulum stress in sepsis[J]. Journal of Clinical Medicine in Practice, 2023, 27(14): 121-125. DOI: 10.7619/jcmp.20230103

Citation:

SHI Ying, YU Jiangquan, ZHANG Wenjuan. Research progress of endoplasmic reticulum stress in sepsis[J]. Journal of Clinical Medicine in Practice, 2023, 27(14): 121-125. DOI: 10.7619/jcmp.20230103

Citation:

SHI Ying, YU Jiangquan, ZHANG Wenjuan. Research progress of endoplasmic reticulum stress in sepsis[J]. Journal of Clinical Medicine in Practice, 2023, 27(14): 121-125. DOI: 10.7619/jcmp.20230103

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Research progress of endoplasmic reticulum stress in sepsis

Department of Critical Care Medicine, Northern Jiangsu People′s Hospital of Jiangsu Province, Yangzhou, Jiangsu, 225002

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Received Date: January 12, 2023
Revised Date: April 01, 2023
Available Online: July 30, 2023

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Abstract

Abstract

Sepsis has high incidence and lack of effective treatment, and it is the leading cause of death in intensive care unit. The endoplasmic reticulum is an organelle, and it is responsible for a series of physiological activities such as protein folding and assembly. Under certain conditions, the endoplasmic reticulum can lose homeostasis, leading to the accumulation of unfolded or misfolded proteins, which is known as endoplasmic reticulum stress (ERs). ERs is associated with sepsis and its related organ dysfunction. This review reviewed the recent advances in ERs, unfolded protein response (UPR) signaling pathways related to sepsis. At the same time, the potential significance of ERs as a therapeutic target for sepsis and its future development direction were discussed.
- endoplasmic reticulum stress,
- sepsis,
- unfolded protein response,
- organ dysfunction,
- therapeutic target

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References (45)

References

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