Objective To investigate the effect of sarcopenia on early postoperative clinical prognosis in patients with gastric cancer.
Methods A total of 189 gastric cancer patients who underwent radical gastrectomy were selected as the study subjects. According to the diagnostic criteria for sarcopenia recommended by the Asian Working Group for Sarcopenia (AWGS) in 2019, they were divided into the sarcopenia group (41 cases) and the non-sarcopenia group (148 cases). The general clinical features of the two groups were compared. The effects of sarcopenia on primary and secondary clinical outcomes in patients with gastric cancer, and independent risk factors for early complications after radical gastrectomy were analyzed.
Results Age, Charson Comorbidities Index (CCI), C-reactive protein (CRP) level, and American Society of Anesthesiologists (ASA) grade were significantly higher in the sarcopenia group, body mass index (BMI) and albumin and hemoglobin levels were significantly lower than those in the non-sarcopenia group (P < 0.05, P < 0.01 or P < 0.001). The incidence of postoperative total early complications in the sarcopenia group was significantly higher than that in the non-sarcopenia group (36.6% versus 14.9%, P=0.002). The postoperative hospital stay in the sarcopenia group was significantly longer than that in the non-sarcopenia group, and the total hospital cost was significantly higher than that in the non-sarcopenia group (P < 0.05 or P < 0.01).
Conclusion Sarcopenia is an independent risk factor for early complications after radical gastrectomy.
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