Advance Search
XIA Dexin, ZUO Junbo, YAN Yulan, ZHANG Zhenzhen, GAO Shengbao, BU Xuefeng. Effect of sarcopenia on early postoperative clinical prognosis of patients with gastric cancer[J]. Journal of Clinical Medicine in Practice, 2023, 27(9): 65-70. DOI: 10.7619/jcmp.20230242
Citation: XIA Dexin, ZUO Junbo, YAN Yulan, ZHANG Zhenzhen, GAO Shengbao, BU Xuefeng. Effect of sarcopenia on early postoperative clinical prognosis of patients with gastric cancer[J]. Journal of Clinical Medicine in Practice, 2023, 27(9): 65-70. DOI: 10.7619/jcmp.20230242
shu

Effect of sarcopenia on early postoperative clinical prognosis of patients with gastric cancer

  • 1.

    School of Clinical Medicine in Jiangsu University, Zhenjiang, Jiangsu, 212013

  • 2.

    Department of General Surgery, People′s Hospital Affiliated to Jiangsu University, Zhenjiang, Jiangsu, 212003

  • 3.

    Department of Respiratory Critical Care, Shenzhen Hospital of Hong Kong University, Shenzhen, Guangdong, 518048

More Information
  • Received Date: February 02, 2023
  • Revised Date: April 07, 2023
  • Available Online: May 24, 2023
    Graphical Abstract
    • Abstract
  • Objective 

    To investigate the effect of sarcopenia on early postoperative clinical prognosis in patients with gastric cancer.

    Methods 

    A total of 189 gastric cancer patients who underwent radical gastrectomy were selected as the study subjects. According to the diagnostic criteria for sarcopenia recommended by the Asian Working Group for Sarcopenia (AWGS) in 2019, they were divided into the sarcopenia group (41 cases) and the non-sarcopenia group (148 cases). The general clinical features of the two groups were compared. The effects of sarcopenia on primary and secondary clinical outcomes in patients with gastric cancer, and independent risk factors for early complications after radical gastrectomy were analyzed.

    Results 

    Age, Charson Comorbidities Index (CCI), C-reactive protein (CRP) level, and American Society of Anesthesiologists (ASA) grade were significantly higher in the sarcopenia group, body mass index (BMI) and albumin and hemoglobin levels were significantly lower than those in the non-sarcopenia group (P < 0.05, P < 0.01 or P < 0.001). The incidence of postoperative total early complications in the sarcopenia group was significantly higher than that in the non-sarcopenia group (36.6% versus 14.9%, P=0.002). The postoperative hospital stay in the sarcopenia group was significantly longer than that in the non-sarcopenia group, and the total hospital cost was significantly higher than that in the non-sarcopenia group (P < 0.05 or P < 0.01).

    Conclusion 

    Sarcopenia is an independent risk factor for early complications after radical gastrectomy.

    • FullText(HTML)
    • References (20)
  • [1]
    NIE Y Z, WU K C, YU J, et al. A global burden of gastric cancer: the major impact of China[J]. Expert Rev Gastroenterol Hepatol, 2017, 11(7): 651-661. doi: 10.1080/17474124.2017.1312342
    [2]
    张飞宇. 肌少症和营养不良对老年胃癌患者根治性胃切除术后并发症的影响[D]. 温州: 温州医科大学, 2017.
    [3]
    YUAN P, WU Z Q, LI Z Y, et al. Impact of postoperative major complications on long-term survival after radical resection of gastric cancer[J]. BMC Cancer, 2019, 19(1): 833. doi: 10.1186/s12885-019-6024-3
    [4]
    CRUZ-JENTOFT A J, BAHAT G, BAUER J, et al. Sarcopenia: revised European consensus on definition and diagnosis[J]. Age Ageing, 2019, 48(4): 601.
    [5]
    TEGELS J J W, VAN VUGT J L A, REISINGER K W, et al. Sarcopenia is highly prevalent in patients undergoing surgery for gastric cancer but not associated with worse outcomes[J]. J Surg Oncol, 2015, 112(4): 403-407. doi: 10.1002/jso.24015
    [6]
    马亮亮, 张飞宇, 王速临, 等. 肌少症对老年进展期胃癌患者根治性胃切除术后并发症的影响[J]. 数理医药学杂志, 2018, 31(2): 170-173
    [7]
    DINDO D, DEMARTINES N, CLAVIEN P A. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey[J]. Ann Surg, 2004, 240(2): 205-213. doi: 10.1097/01.sla.0000133083.54934.ae
    [8]
    KONDRUP J. ESPEN guidelines for nutrition screening 2002[J]. Clin Nutr, 2003, 22(4): 415-421. doi: 10.1016/S0261-5614(03)00098-0
    [9]
    WANG Y, WANG Y, LI G D, et al. Associations of intermuscular adipose tissue and total muscle wasting score in PG-SGA with low muscle radiodensity and mass in nonmetastatic colorectal cancer: a two-center cohort study[J]. Front Nutr, 2022, 9: 967902. doi: 10.3389/fnut.2022.967902
    [10]
    LIANG-KUNG, CHEN, MD P, et al. Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment[J]. J Am Med Dir Assoc, 2020, 21(3): 300-307, e2. doi: 10.1016/j.jamda.2019.12.012
    [11]
    CHEN F, CHI J T, LIU Y, et al. Impact of preoperative sarcopenia on postoperative complications and prognosis of gastric cancer resection: a meta-analysis of cohort studies[J]. Arch Gerontol Geriatr, 2022, 98: 104534. doi: 10.1016/j.archger.2021.104534
    [12]
    BARACOS V E, MARTIN L, KORC M, et al. Cancer-associated cachexia[J]. Nat Rev Dis Primers, 2018, 4: 17105. doi: 10.1038/nrdp.2017.105
    [13]
    杨君红, 梁兰玉, 单清. 慢性阻塞性肺疾病合并肌少症研究进展[J]. 实用临床医药杂志, 2021, 25(3): 120-124. doi: 10.7619/jcmp.20201598
    [14]
    BARAZZONI R, JENSEN G L, CORREIA M I T D, et al. Guidance for assessment of the muscle mass phenotypic criterion for the Global Leadership Initiative on Malnutrition (GLIM) diagnosis of malnutrition[J]. Clin Nutr, 2022, 41(6): 1425-1433. doi: 10.1016/j.clnu.2022.02.001
    [15]
    ZHUANG C L, HUANG D D, PANG W Y, et al. Sarcopenia is an independent predictor of severe postoperative complications and long-term survival after radical gastrectomy for gastric cancer: analysis from a large-scale cohort[J]. Medicine (Baltimore), 2016, 95(13): e3164.
    [16]
    田浩, 周达, 叶晨, 等. 术前肌肉减少症对胃癌病人临床预后的影响: 一项前瞻性队列研究[J]. 肠外与肠内营养, 2018, 25(3): 166-170, 175. https://www.cnki.com.cn/Article/CJFDTOTAL-CWCN201803014.htm
    [17]
    LI L, JI, . Exercise-induced hormesis and skeletal muscle health[J]. Free Radic Biol Med, 2016, 98: 113-122. doi: 10.1016/j.freeradbiomed.2016.02.025
    [18]
    IDA S, WATANABE M, YOSHIDA N, et al. Sarcopenia is a predictor of postoperative respiratory complications in patients with esophageal cancer[J]. Ann Surg Oncol, 2015, 22(13): 4432-4437. doi: 10.1245/s10434-015-4559-3
    [19]
    ZHANG F M, CHEN X L, WU Q, et al. Development and validation of nomograms for the prediction of low muscle mass and radiodensity in gastric cancer patients[J]. Am J Clin Nutr, 2021, 113(2): 348-358.
    [20]
    肖海燕, 刘婷, 李岱, 等. 胃癌合并肌少症的研究进展[J]. 中国普通外科杂志, 2022, 31(8): 1121-1128. https://www.cnki.com.cn/Article/CJFDTOTAL-ZPWZ202208015.htm
    • Related Articles

  • Cited by

    Periodical cited type(4)

    1. 陶梦珂，李苗苗，石晴晴，赵恒，张鲁星，胡功政，潘玉善，刘建华. 鸡源大肠杆菌生物被膜形成与耐药性、毒力基因的关联性分析. 畜牧与兽医. 2024(06): 86-93 .
    2. 高远，袁志浩，王永鑫，辛文成，乔保平. 八宝丹胶囊预防导尿管相关性尿路感染的效果. 郑州大学学报(医学版). 2024(05): 701-703 .
    3. 林秀慧，许政衡，林秀华，王诗佳，张娇珍. 老年导尿管相关尿路感染生物被膜菌分布特征及生物被膜形成相关基因. 中华医院感染学杂志. 2023(05): 718-722 .
    4. 袁杭海，马志芳，唐补生，郭华伟，张海春，丁一波. 尿路感染的现代研究和中医治疗进展. 河北中医. 2023(07): 1199-1202 .

    Other cited types(2)

Catalog

    Get Citation
    PDF
    XML
    Article views PDF downloads Cited by(6)
    Turn off MathJax
    Article Contents
    Abstract
    References

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return