Study on the medication law of internal treatment of ecthyma in ancient medical records based on data mining

CHENG Zhixin; GONG Rui; ZHANG Yue; XU Jiaxiang; KUANG Yingjie

doi:10.7619/jcmp.20230525

Journal of Clinical Medicine in Practice > 2023 > 27(10): 25-30. > DOI: 10.7619/jcmp.20230525

CHENG Zhixin, GONG Rui, ZHANG Yue, XU Jiaxiang, KUANG Yingjie. Study on the medication law of internal treatment of ecthyma in ancient medical records based on data mining[J]. Journal of Clinical Medicine in Practice, 2023, 27(10): 25-30. DOI: 10.7619/jcmp.20230525

Citation:

PDF (2085 KB)

Study on the medication law of internal treatment of ecthyma in ancient medical records based on data mining

1.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250014
2.
Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250014

More Information

Received Date: February 21, 2023
Revised Date: April 10, 2023
Available Online: June 06, 2023

Graphical Abstract

Abstract

Abstract

Objective
To explore the regularity of medication for ecthyma in ancient medical records by data mining.
Methods
The effective proven cases of internal treatment of ecthyma by TCM were searched by using the "Ancient and Modern Medical Record Cloud Platform" and Chinese Medical Dictionary. After standardized data collection, the prescription, frequency of drug use, four qi and five flavors of drugs were analyzed by using the Ancient and Modern Medical Record Cloud Platform, and cluster analysis and complex network were performed, and medication regularity of ancient physicians in the treatment of ecthyma was analyzed.
Results
A total of 108 ancient medical records were selected(157 consultations in total), involving 30 formulas and 179 herbs, the most frequently used formula was Buzhong Yiqi Decoction, and the top five drugs in the frequency of drug use were Gancao, Danggui, Baizhu, Fuling and Chaihu. The taste of majority of the drug was warm and sweet, and affinity of meridians was spleen meridian, lung meridian, and heart meridian. A total of 9 drug pair combinations were obtained by association analysis, with higher support of Danggui-Baizhu and Baizhu-Fuling. Cluster and complex network analysis yielded core prescriptions composed of Baizhu, Danggui, Gancao, Chaihu, Fuling, Huangqi, Chenpi, Renshen, Shengma, Dangshen, Baishao, Chuanxiong, Shudihuang.
Conclusion
In ancient medical records, the main treatment of ecthyma is mostly based on tonifying qi and blood and eliminating pathogenic factors, which reflects the theoretical idea of treating both cause and symptoms.
- data mining,
- ancient medical records,
- ecthyma,
- internal treatment,
- medication law,
- treating both causes and symptoms,
- drug pair

FullText(HTML)

References (17)

References

[1]	ALAVI A, SIBBALD R G, PHILLIPS T J, et al. What's new: management of venous leg ulcers: approach to venous leg ulcers[J]. J Am Acad Dermatol, 2016, 74(4): 627-640. doi: 10.1016/j.jaad.2014.10.048
[2]	NEUMANN M. Evidence-based (S3) Guidelines for Diagnostics and treatment of venous leg ulcers-Answer to Dr Bertolini[J]. J Eur Acad Dermatol Venereol, 2017, 31(9): e386. doi: 10.1111/jdv.14182/abstract
[3]	章新友, 王姝, 唐琍萍, 等. 数据挖掘在中医治疗痛风性关节炎中的应用[J]. 中华中医药学刊, 2022, 40(7): 1-5. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202207001.htm
[4]	范丽君, 王缙, 赵金妹. 中医古籍中臁疮病名考证[J]. 亚太传统医药, 2018, 14(12): 85-86. https://www.cnki.com.cn/Article/CJFDTOTAL-YTCT201812030.htm
[5]	国家药典委员会. 中华人民共和国药典一部(2020年版)[M]. 北京: 中国医药科技出版社, 2020: 112-116.
[6]	莫嘉浩, 綦向军, 高帅, 等. 基于《新编国家中成药》治呕中成药组方分析[J]. 中国现代应用药学, 2020, 37(10): 1171-1176. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYD202010004.htm
[7]	陈凯丽, 陈占科, 陈昺伃, 等. 含虫类药处方治疗糖尿病肾病的用药规律[J]. 实用临床医药杂志, 2022, 26(18): 87-92, 97. doi: 10.7619/jcmp.20221620
[8]	莫嘉浩, 梁浩锐, 许洪彬, 等. 基于古今医案云平台的抑郁症中医处方用药规律分析[J]. 国际中医中药杂志, 2021, 43(5): 492-497.
[9]	XU C L, LIANG C H, SUN W X, et al. Glycyrrhizic acid ameliorates myocardial ischemic injury by the regulation of inflammation and oxidative state[J]. Drug Des Devel Ther, 2018, 12: 1311-1319. http://www.scienceopen.com/document_file/4fb43a0f-b4ae-44d2-ac99-d1f1843333a1/PubMedCentral/4fb43a0f-b4ae-44d2-ac99-d1f1843333a1.pdf
[10]	商安康, 林伟刚, 于成, 等. 基于数据挖掘的臁疮内服中药用药规律研究[J]. 中医临床研究, 2021, 13(16): 66-69. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYLY202116020.htm
[11]	张苏颖. "血不利则为水"的机制及临床意义[J]. 山东中医药大学学报, 2002, 26(2): 93-96. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYX200202003.htm
[12]	胡慧娟, 杭秉茜, 王朋书. 当归的抗炎作用[J]. 中国中药杂志, 1991, 16(11): 684-686, 704. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY199111024.htm
[13]	胡晶, 冯敏, 杨慧, 等. 当归多糖动员的造血干/祖细胞移植重建小鼠造血功能的研究[J]. 第三军医大学学报, 2007, 29(23): 2236-2239. https://www.cnki.com.cn/Article/CJFDTOTAL-DSDX200723013.htm
[14]	陈琴华, 余飞, 王红梅, 等. 白术内酯Ⅰ、Ⅱ、Ⅲ对炎性巨噬细胞细胞因子表达的影响[J]. 中国药师, 2017, 20(12): 2112-2116. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYSG201712005.htm
[15]	陈云, 王婷婷, 郝明明, 等. 茯苓酸对LPS诱导的急性肺损伤小鼠的保护作用及机制[J]. 广东药科大学学报, 2022, 38(1): 83-89. https://www.cnki.com.cn/Article/CJFDTOTAL-GDYX202201014.htm
[16]	闫丽丽. 中医中药治疗慢性皮肤溃疡36例[J]. 中国中医药现代远程教育, 2010, 8(10): 18-19. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYY201010019.htm
[17]	孔令臻, 邢捷. 四君子汤、四物汤对体外培养人皮肤成纤维细胞EGF、EGF mRNA、VEGFA、VEGF mRNA表达的影响[J]. 上海中医药杂志, 2021, 55(7): 75-80. https://www.cnki.com.cn/Article/CJFDTOTAL-SHZZ202107018.htm

Cited By

Cited by

Periodical cited type(5)

1.	万建平，周强. 经直肠超声造影检查联合血清前列腺特异性抗原检测对前列腺癌的诊断及预后预测价值. 癌症进展. 2025(02): 236-239 .
2.	李正平，李永芬，王生鹏. 前列腺尿道悬吊术对小体积良性前列腺增生患者下尿路功能、血清炎症-应激因子、并发症的影响. 微创泌尿外科杂志. 2025(01): 31-37 .
3.	王安勇，高余杰，黄学东，张衡，朱杰. 尿道前列腺切除术联合经尿道膀胱取石治疗老年前列腺增生伴膀胱结石的疗效及预后. 中国临床医生杂志. 2024(03): 290-294 .
4.	潘宗森，王慧. 经尿道前列腺钬激光剜除术在大体积良性前列腺增生中的应用效果. 浙江创伤外科. 2024(03): 538-541 .
5.	黄登辉，周广臣. 前列腺特异性抗原灰区患者前列腺穿刺活检结果的相关影响因素分析. 实用临床医药杂志. 2023(15): 77-81 . 本站查看

Other cited types(0)

Get Citation

PDF

XML

Article views PDF downloads Cited by(5)

Turn off MathJax

Article Contents

Abstract

References

Study on the medication law of internal treatment of ecthyma in ancient medical records based on data mining

Abstract

References

Cited by

Periodical cited type(5)

Other cited types(0)

Catalog

Export File

Citation

Format

Content