Predictive value of serum matrix metalloproteinase-9 and neurofilament light chain levels for cognitive impairment patients after first-onset ischemic stroke

SHAN Na; ZHAO Li; LIN Xiaodong

doi:10.7619/jcmp.20230606

Journal of Clinical Medicine in Practice > 2023 > 27(8): 67-70, 90. > DOI: 10.7619/jcmp.20230606

SHAN Na, ZHAO Li, LIN Xiaodong. Predictive value of serum matrix metalloproteinase-9 and neurofilament light chain levels for cognitive impairment patients after first-onset ischemic stroke[J]. Journal of Clinical Medicine in Practice, 2023, 27(8): 67-70, 90. DOI: 10.7619/jcmp.20230606

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Predictive value of serum matrix metalloproteinase-9 and neurofilament light chain levels for cognitive impairment patients after first-onset ischemic stroke

Department of Neurology, the Second Hospital of Qinhuangdao in Hebei Province, Qinhuangdao, Hebei, 066600

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Received Date: February 28, 2023
Revised Date: April 19, 2023
Available Online: May 10, 2023

Graphical Abstract

Abstract

Abstract

Objective
To investigate the predictive value of serum matrix metalloproteinase-9 (MMP-9) and neurofilament light chain (NFL) for post-stroke cognitive impairment (PSCI) in patients with first-onset acute ischemic stroke (AIS).
Methods
Eighty patients with AIS were selected. According to Montreal Cognitive Assessment (MoCA) score after 6 months of stroke, they were divided into PSCI group (MoCA score < 26) and non-PSCI group (MoCA score ≥26). The serum levels of MMP-9 and NFL were compared between the two groups on admission; the correlations of MMP-9 and NFL level with MoCA score were analyzed; the Logistic regression model was used to determine the risk factors of PSCI; the receiver operating characteristic (ROC) curve was used to evaluate the predictive efficacy of MMP-9 and NFL levels on PSCI.
Results
The serum levels of MMP-9 and NFL in the PSCI group were significantly higher than those in the non-PSCI group (P < 0.05). Pearson correlation analysis showed that MMP-9 and NFL levels at admission were negatively correlated with MoCA scores 6 months after discharge (r=-0.457, -0.512; P < 0.05). Logistic regression analysis showed that age (OR=1.468), MMP-9 level (OR=1.694) and NFL level (OR=1.802) were independent influencing factors for PSCI in patients with first-ever AIS (P < 0.05). ROC curve analysis showed that the area under the curve (AUC) of MMP-9 and NFL level predicting the occurrence of PSCI at admission were 0.805 and 0.833, respectively; the AUC predicted by the combination of the two indexes was 0.905, which was higher than that of a single index, and the difference was statistically significant (P < 0.05).
Conclusion
Both MMP-9 and NFL can be used as predictors of PSCI occurrence in patients with first-onset AIS, and their combined evaluation can further improve the predictive efficacy.
- acute ischemic stroke,
- post-stroke cognitive impairment,
- matrix metalloproteinase-9,
- neurofilament light chain

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References

[1]	汪凯, 董强. 卒中后认知障碍管理专家共识2021[J]. 中国卒中杂志, 2021, 16(4): 376-389. doi: 10.3969/j.issn.1673-5765.2021.04.011
[2]	LI J, WANG J, WU B, et al. Association between early cognitive impairment and midterm functional outcomes among Chinese acute ischemic stroke patients: a longitudinal study[J]. Front Neurol, 2020, 11: 20. doi: 10.3389/fneur.2020.00020
[3]	OBAID M, FLACH C, MARSHALL I, et al. Long-term outcomes in stroke patients with cognitive impairment: a population-based study[J]. Geriatrics (Basel), 2020, 5(2): 32. doi: 10.3390/geriatrics5020032
[4]	ZHONG C K, BU X Q, XU T, et al. Serum matrix metalloproteinase-9 and cognitive impairment after acute ischemic stroke[J]. J Am Heart Assoc, 2018, 7(1): e007776. doi: 10.1161/JAHA.117.007776
[5]	UPHAUS T, BITTNER S, GR?SCHEL S, et al. NfL (neurofilament light chain) levels as a predictive marker for long-term outcome after ischemic stroke[J]. Stroke, 2019, 50(11): 3077-3084. doi: 10.1161/STROKEAHA.119.026410
[6]	张颖, 张春丽, 李璐, 等. 血管性痴呆患者血清MMP-9, NLRP3, Hcy水平变化及其与认知、神经功能、预后的关系[J]. 卒中与神经疾病, 2021, 28(1): 67-72. doi: 10.3969/j.issn.1007-0478.2021.01.014
[7]	张雪卫, 傅强. 脑脊液中β淀粉样蛋白42和神经丝轻链蛋白水平与术后神经认知功能障碍的相关性: 基于90例66~78岁患者[J]. 南方医科大学学报, 2021, 41(4): 574-578.
[8]	O′DRISCOLL C, SHAIKH M. Cross-cultural applicability of the Montreal cognitive assessment (MoCA): a systematic review[J]. J Alzheimers Dis, 2017, 58(3): 789-801. doi: 10.3233/JAD-161042
[9]	王安安, 李文娟. 脑卒中后认知功能障碍的中医治疗研究进展[J]. 中西医结合心脑血管病杂志, 2022, 20(14): 2565-2568.
[10]	ZHU Z B, ZHONG C K, GUO D X, et al. Multiple biomarkers covering several pathways improve predictive ability for cognitive impairment among ischemic stroke patients with elevated blood pressure[J]. Atherosclerosis, 2019, 287: 30-37. doi: 10.1016/j.atherosclerosis.2019.05.028
[11]	ZHANG X X, BI X. Post-stroke cognitive impairment: a review focusing on molecular biomarkers[J]. J Mol Neurosci, 2020, 70(8): 1244-1254. doi: 10.1007/s12031-020-01533-8
[12]	刘梦珂, 郭潇潇, 职玲云, 等. CDDO-Im对缺血性脑卒中大鼠神经功能损伤修复的影响[J]. 中国病理生理杂志, 2022, 38(4): 651-657
[13]	ZHONG C K, YANG J Y, XU T, et al. Serum matrix metalloproteinase-9 levels and prognosis of acute ischemic stroke[J]. Neurology, 2017, 89(8): 805-812. doi: 10.1212/WNL.0000000000004257
[14]	WEEKMAN E M, WILCOCK D M. Matrix metalloproteinase in blood-brain barrier breakdown in dementia[J]. J Alzheimers Dis, 2016, 49(4): 893-903. doi: 10.3233/JAD-150759
[15]	张冬, 解战兵. 高原地区缺血性脑卒中患者血清基质金属蛋白酶-9、低氧诱导因子-1α表达及临床意义[J]. 国际神经病学神经外科学杂志, 2020, 47(3): 277-281.
[16]	BORGWARDT L, DANIELSEN E R, THOMSEN C, et al. Alpha-mannosidosis: characterization of CNS pathology and correlation between CNS pathology and cognitive function[J]. Clin Genet, 2016, 89(4): 489-494. doi: 10.1111/cge.12642
[17]	麦尔哈巴·赛里木, 郭晨晨, 张清瑜, 等. 神经丝轻链蛋白在阿尔茨海默病早期诊断中的作用研究[J]. 重庆医科大学学报, 2021, 46(11): 1355-1359.
[18]	陈晨晖, 程楠, 向常清, 等. 急性缺血性脑卒中患者血清神经丝蛋白轻链、泛素羧基末端水解酶L1表达及其预后相关性[J]. 国际检验医学杂志, 2021, 42(18): 2195-2199.
[19]	TIEDT S, DUERING M, BARRO C, et al. Serum neurofilament light: a biomarker of neuroaxonal injury after ischemic stroke[J]. Neurology, 2018, 91(14): e1338-e1347.
[20]	PEDERSEN A, STANNE T M, NILSSON S, et al. Circulating neurofilament light in ischemic stroke: temporal profile and outcome prediction[J]. J Neurol, 2019, 266(11): 2796-2806.
[21]	张君琴, 张国新, 张振涛. 急性缺血性脑卒中后认知障碍的危险因素分析[J]. 中风与神经疾病杂志, 2021, 38(1): 32-35.
[22]	汤爱洁, 戴秀娟, 胡鑫淼, 等. 缺血性脑卒中后3~6个月认知障碍影响因素的Meta分析[J]. 中国全科医学, 2022, 25(24): 3049-3056, 3064.

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Predictive value of serum matrix metalloproteinase-9 and neurofilament light chain levels for cognitive impairment patients after first-onset ischemic stroke

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