Objective To explore the significance of inflammatory response indicatorsplatelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR)and tumor markerscarbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199)in predicting the prognosis of patients undergoing endometrial carcinoma surgery.
Methods A total of 131 patients with endometrial carcinoma who underwent surgeryat the Affiliated Hospital of Yangzhou University were selected as study subjects. Effective clinical data were extracted by searching the clinical medical record system. Univariate and multivariate survival analysis of different clinical variables was performed using COX proportional risk model, and chi-test was used to analyze the relationship between inflammatory response indicators and clinical variables, and Kaplan-Meier analysis was used to compare the overall survival rate of patients with different preoperative and postoperative NLR levels.
Results The results of univariate analysis showed that FIGO stage, CA199 level and preoperative NLR level were correlated with overall survival and disease-free survival, respectively (P < 0.05). Postoperative radiotherapy and postoperative NLR levels were only significantly correlated with disease-free survival (P < 0.05). The results of multivariate analysis showed that postoperative radiotherapy and CA199 level were significantly correlated with overall survival (P < 0.05), and preoperative NLR level and postoperative NLR level were separately significantly correlated with overall survival and disease-free survival (P < 0.05). Kaplan-Meier survival analysis showed that both high preoperative NLR (χ2=16.871, P < 0.001) and high postoperative NLR (χ2=3.966, P=0.046) were significantly associated with lower overall survival.
Conclusion Both preoperative and postoperative high NLR are significantly associated with lower overall survival after endometrial cancer surgery, and may be used to predict the prognosis of patients with endometrial cancer after surgery.
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