Effects of individualized nutrition intervention on sarcopenia and quality of life in maintenance hemodialysis patients

Objective To explore effects of individualized nutrition intervention on sarcopenia and quality of life in maintenance hemodialysis(MHD)patients.

Methods A total of 102 patients who received regular hemodialysis for more than 6 months were selected as research objects, and their general data were collected, biochemical indexes were detected, and skeletal muscle mass index, grip strength and daily walking speed were measured. According to the diagnostic criteria of Asian Sarcopenia Working Group (AWGS), the objects were divided into sarcopenia-free group(n=74) and sarcopenia group(n=28). Patients in both groups were given individualized nutritional intervention for 3 months, and the changes of sarcopenia and quality of life before and after treatment were compared. The clinical data and related indicators of sarcopenia (skeletal muscle mass index, grip strength, daily walking speed) and quality of life36-item Shot-form Health Status Survey(SF-36)score of the two groups were compared before and after treatment.

Results Among 102 subjects, the incidence of sarcopenia was 27.45%(28/102), and there were statistical differences in age, sex, body mass index, serum albumin, hypersensitive C-reactive protein, blood urea nitrogen, blood creatinine between the two groups (P < 0.05). Before treatment, the physiological function, body pain, general health dimension score, total score in physical health field and total score of SF-36 Scale in the sarcopenia group were lower than those of the sarcopenia-free group (P < 0.05). After treatment, the skeletal muscle mass indexes and grip strength of two groups were higher than before treatment, and skeletal muscle mass indexes and the difference value of grip strength before and after treatment of the sarcopenia group were greater than those of sarcopenia-free group (P < 0.05). There was no significant difference in daily walking speed between two groups before and after treatment (P>0.05). After treatment, the physiological function, general health status, energy dimension score, total score of physiological health field and total score of SF-36 Scale of MHD patients were higher than before treatment (P < 0.05).

Conclusion The prevalence of sarcopenia in MHD patients is high, which is related to age, gender, nutritional status and microinflammation, and seriously affects the quality of life of patients. Individualized nutritional intervention therapy can effectively relieve the sarcopenia and improve the quality of life of patients.