Research progress of long non-coding RNA lung adenocarcinoma metastasis-associated transcript 1 in colorectal cancer

FAN Chengfeng; YANG Jinsong

doi:10.7619/jcmp.20231751

Journal of Clinical Medicine in Practice > 2023 > 27(14): 115-120. > DOI: 10.7619/jcmp.20231751

FAN Chengfeng, YANG Jinsong. Research progress of long non-coding RNA lung adenocarcinoma metastasis-associated transcript 1 in colorectal cancer[J]. Journal of Clinical Medicine in Practice, 2023, 27(14): 115-120. DOI: 10.7619/jcmp.20231751

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Research progress of long non-coding RNA lung adenocarcinoma metastasis-associated transcript 1 in colorectal cancer

FAN Chengfeng,
YANG Jinsong^,

Department of Medical Oncology, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 210006

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Received Date: May 30, 2023
Revised Date: July 06, 2023
Available Online: July 30, 2023

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Abstract

Abstract

Long non-coding RNA (lncRNA) is a kind of RNA with a length of more than 200 nucleotides, which does not have the ability to encode proteins, and plays an important role in the development of cancer. LncRNAs are involved in various gene regulatory processes such as transcription, post-transcriptional modification, chromatin modification and epigenetic modification, and are the most important participants in biological processes such as cell cycle, cell differentiation and development, and cell pluripotency. As one of the most widely studied lncRNAs, metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) is highly expressed in colorectal cancer. Studies have shown that MALAT1 and its single nucleotide polymorphisms (SNPs) play important roles in the occurrence and development of colorectal cancer, and can be used as targets for clinical diagnosis, treatment and prognosis of colorectal cancer. This article reviewed the current status of research on lncRNA MALAT1 in colorectal cancer.

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References

[1]	SUNG H, FERLAY J, SIEGEL R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. doi: 10.3322/caac.21660
[2]	QUINN J J, CHANG H Y. Unique features of long non-coding RNA biogenesis and function[J]. Nat Rev Genet, 2016, 17(1): 47-62. doi: 10.1038/nrg.2015.10
[3]	ARUN G, AGGARWAL D, SPECTOR D L. MALAT1 long non-coding RNA: functional implications[J]. Noncoding RNA, 2020, 6(2): 22.
[4]	胡志立, 张明明. MALAT1参与胃癌发生发展机制的研究进展[J]. 临床医学研究与实践, 2022, 7(1): 195-198. https://www.cnki.com.cn/Article/CJFDTOTAL-YLYS202201049.htm
[5]	孙永康, 颜学波, 朱泽民, 等. 长链非编码RNA MALAT1在肝细胞癌发生发展中的作用[J]. 临床肝胆病杂志, 2021, 37(3): 704-708. https://www.cnki.com.cn/Article/CJFDTOTAL-LCGD202103051.htm
[6]	冯以国, 贺林, 印隆宽, 等. 长链非编码RNA人肺腺癌转移相关转录1与结直肠癌发生发展的研究进展[J]. 山东医药, 2021, 61(28): 104-106. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYY202128026.htm
[7]	HUTCHINSON J N, ENSMINGER A W, CLEMSON C M, et al. A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains[J]. BMC Genomics, 2007, 8: 39. doi: 10.1186/1471-2164-8-39
[8]	LIN R, MAEDA S, LIU C, et al. A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas[J]. Oncogene, 2007, 26(6): 851-858. doi: 10.1038/sj.onc.1209846
[9]	JI P, DIEDERICHS S, WANG W B, et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer[J]. Oncogene, 2003, 22(39): 8031-8041. doi: 10.1038/sj.onc.1206928
[10]	DAI Q Q, ZHANG T Q, LI C. LncRNA MALAT1 regulates the cell proliferation and cisplatin resistance in gastric cancer via PI3K/AKT pathway[J]. Cancer Manag Res, 2020, 12: 1929-1939. doi: 10.2147/CMAR.S243796
[11]	JI D G, GUAN L Y, LUO X, et al. Inhibition of MALAT1 sensitizes liver cancer cells to 5-flurouracil by regulating apoptosis through IKKα/NF-κB pathway[J]. Biochem Biophys Res Commun, 2018, 501(1): 33-40. doi: 10.1016/j.bbrc.2018.04.116
[12]	JI Q, ZHANG L, LIU X, et al. Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex[J]. Br J Cancer, 2014, 111(4): 736-748. doi: 10.1038/bjc.2014.383
[13]	FEI J Y, JADALIHA M, HARMON T S, et al. Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution[J]. J Cell Sci, 2017, 130(24): 4180-4192.
[14]	TRIPATHI V, ELLIS J D, SHEN Z, et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation[J]. Mol Cell, 2010, 39(6): 925-938. doi: 10.1016/j.molcel.2010.08.011
[15]	YANG F, YI F, HAN X R, et al. MALAT-1 interacts with hnRNP C in cell cycle regulation[J]. FEBS Lett, 2013, 587(19): 3175-3181. doi: 10.1016/j.febslet.2013.07.048
[16]	CHEN R B, LIU Y, ZHUANG H, et al. Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation[J]. Nucleic Acids Res, 2017, 45(17): 9947-9959. doi: 10.1093/nar/gkx600
[17]	ARUN G, DIERMEIER S D, SPECTOR D L. Therapeutic targeting of long non-coding RNAs in cancer[J]. Trends Mol Med, 2018, 24(3): 257-277. doi: 10.1016/j.molmed.2018.01.001
[18]	CHALESHI V, IRANI S, ALEBOUYEH M, et al. Association of lncRNA-p53 regulatory network (lincRNA-p21, lincRNA-ROR and MALAT1) and p53 with the clinicopathological features of colorectal primary lesions and tumors[J]. Oncol Lett, 2020, 19(6): 3937-3949.
[19]	SIDDIQUE H, AL-GHAFARI A, CHOUDHRY H, et al. Long noncoding RNAs as prognostic markers for colorectal cancer in Saudi patients[J]. Genet Test Mol Biomarkers, 2019, 23(8): 509-514. doi: 10.1089/gtmb.2018.0308
[20]	SISKOVA A, KRAL J, DRABOVA J, et al. Discovery of long non-coding RNA MALAT1 amplification in precancerous colorectal lesions[J]. Int J Mol Sci, 2022, 23(14): 7656. doi: 10.3390/ijms23147656
[21]	YANG M H, HU Z Y, XU C, et al. MALAT1 promotes colorectal cancer cell proliferation/migration/invasion via PRKA kinase anchor protein 9[J]. Biochim Biophys Acta, 2015, 1852(1): 166-174. doi: 10.1016/j.bbadis.2014.11.013
[22]	ZHANG J J, LI Q, XUE B, et al. MALAT1 inhibits the Wnt/β-catenin signaling pathway in colon cancer cells and affects cell proliferation and apoptosis[J]. Bosn J Basic Med Sci, 2020, 20(3): 357-364.
[23]	WU C Q, ZHU X J, TAO K X, et al. MALAT1 promotes the colorectal cancer malignancy by increasing DCP1A expression and miR203 downregulation[J]. Mol Carcinog, 2018, 57(10): 1421-1431. doi: 10.1002/mc.22868
[24]	WU Q, MENG W Y, JIE Y, et al. LncRNA MALAT1 induces colon cancer development by regulating miR-129-5p/HMGB1 axis[J]. J Cell Physiol, 2018, 233(9): 6750-6757. doi: 10.1002/jcp.26383
[25]	SI Y R, YANG Z G, GE Q X, et al. Long non-coding RNA Malat1 activated autophagy, hence promoting cell proliferation and inhibiting apoptosis by sponging miR-101 in colorectal cancer[J]. Cell Mol Biol Lett, 2019, 24: 50. doi: 10.1186/s11658-019-0175-8
[26]	XU Y L, ZHANG X H, HU X F, et al. The effects of lncRNA MALAT1 on proliferation, invasion and migration in colorectal cancer through regulating SOX9[J]. Mol Med, 2018, 24(1): 52. doi: 10.1186/s10020-018-0050-5
[27]	TANG D X, YANG Z, LONG F X, et al. Inhibition of MALAT1 reduces tumor growth and metastasis and promotes drug sensitivity in colorectal cancer[J]. Cell Signal, 2019, 57: 21-28. doi: 10.1016/j.cellsig.2019.01.013
[28]	LI P L, ZHANG X, WANG H Y, et al. MALAT1 is associated with poor response to oxaliplatin-based chemotherapy in colorectal cancer patients and promotes chemoresistance through EZH2[J]. Mol Cancer Ther, 2017, 16(4): 739-751. doi: 10.1158/1535-7163.MCT-16-0591
[29]	XIE J J, LI W H, LI X, et al. LncRNA MALAT1 promotes colorectal cancer development by sponging miR-363-3p to regulate EZH2 expression[J]. J Biol Regul Homeost Agents, 2019, 33(2): 331-343.
[30]	WU X N, LI R X, SONG Q, et al. JMJD2C promotes colorectal cancer metastasis via regulating histone methylation of MALAT1 promoter and enhancing β-catenin signaling pathway[J]. J Exp Clin Cancer Res, 2019, 38(1): 435. doi: 10.1186/s13046-019-1439-x
[31]	JI Q, CAI G X, LIU X, et al. MALAT1 regulates the transcriptional and translational levels of proto-oncogene RUNX2 in colorectal cancer metastasis[J]. Cell Death Dis, 2019, 10(6): 378. doi: 10.1038/s41419-019-1598-x
[32]	CASTELLANI G, BUCCARELLI M, LULLI V, et al. miR-378a-3p acts as a tumor suppressor in colorectal cancer stem-like cells and affects the expression of MALAT1 and NEAT1 lncRNAs[J]. Front Oncol, 2022, 12: 867886. doi: 10.3389/fonc.2022.867886
[33]	ZHOU J M, WANG M, MAO A R, et al. Long noncoding RNA MALAT1 sponging miR-26a-5p to modulate Smad1 contributes to colorectal cancer progression by regulating autophagy[J]. Carcinogenesis, 2021, 42(11): 1370-1379. doi: 10.1093/carcin/bgab069
[34]	HU H X, LIU S Y, CHU A N, et al. Comprehensive analysis of ceRNA network of ERCC4 in colorectal cancer[J]. Peer J, 2021, 9: e12647. doi: 10.7717/peerj.12647
[35]	ŽLAJPAH M, URH K, GROSEK J, et al. Differential expression of decorin in metastasising colorectal carcinoma is regulated by miR-200c and long non-coding RNAs[J]. Biomedicines, 2022, 10(1): 142. doi: 10.3390/biomedicines10010142
[36]	AGARWAL S, AFAQ F, BAJPAI P, et al. BZW2 inhibition reduces colorectal cancer growth and metastasis[J]. Mol Cancer Res, 2023, 21(7): 698-712. doi: 10.1158/1541-7786.MCR-23-0003
[37]	LUAN N, WANG J J, SHENG B, et al. tRF-20-M0NK5Y93-induced MALAT1 promotes colon cancer metastasis through alternative splicing of SMC1A[J]. Am J Cancer Res, 2023, 13(3): 852-871.
[38]	RADWAN A F, SHAKER O G, EL-BOGHDADY N A, et al. Association of MALAT1 and PVT1 variants, expression profiles and target miRNA-101 and miRNA-186 with colorectal cancer: correlation with epithelial-mesenchymal transition[J]. Int J Mol Sci, 2021, 22(11): 6147. doi: 10.3390/ijms22116147
[39]	KWOK Z H, ROCHE V, CHEW X H, et al. A non-canonical tumor suppressive role for the long non-coding RNAMALAT1in colon and breast cancers[J]. Int J Cancer, 2018, 143(3): 668-678. doi: 10.1002/ijc.31386
[40]	JIANG X, LI D Y, WANG G Q, et al. Thapsigargin promotes colorectal cancer cell migration through upregulation of lncRNA MALAT1[J]. Oncol Rep, 2020, 43(4): 1245-1255.
[41]	WANG S Y, ZHANG L J, CHEN G J, et al. COPA A-to-I RNA editing hijacks endoplasmic reticulum stress to promote metastasis in colorectal cancer[J]. Cancer Lett, 2023, 553: 215995. doi: 10.1016/j.canlet.2022.215995
[42]	ZHAO K X, JIN S, WEI B, et al. Association study of genetic variation of lncRNA MALAT1 with carcinogenesis of colorectal cancer[J]. Cancer Manag Res, 2018, 10: 6257-6261. doi: 10.2147/CMAR.S177244
[43]	XU J C, XIAO Y, LIU B, et al. Exosomal MALAT1 sponges miR-26a/26b to promote the invasion and metastasis of colorectal cancer via FUT4 enhanced fucosylation and PI3K/Akt pathway[J]. J Exp Clin Cancer Res, 2020, 39(1): 54. doi: 10.1186/s13046-020-01562-6
[44]	GHARIB E, NAZEMALHOSSEINI-MOJARAD E, BAGHDAR K, et al. Identification of a stool long non-coding RNAs panel as a potential biomarker for early detection of colorectal cancer[J]. J Clin Lab Anal, 2021, 35(2): e23601.
[45]	SHEN W Q, YU Q F, PU Y W, et al. Upregulation of long noncoding RNA MALAT1 in colorectal cancer promotes radioresistance and aggressive malignance[J]. Int J Gen Med, 2022, 15: 8365-8380. doi: 10.2147/IJGM.S393270
[46]	YAO P A, WU Y, ZHAO K, et al. The feedback loop of ANKHD1/lncRNA MALAT1/YAP1 strengthens the radioresistance of CRC by activating YAP1/AKT signaling[J]. Cell Death Dis, 2022, 13(2): 103. doi: 10.1038/s41419-022-04554-w
[47]	FAN C R, YUAN Q L, LIU G F, et al. Long non-coding RNA MALAT1 regulates oxaliplatin-resistance via miR-324-3p/ADAM17 axis in colorectal cancer cells[J]. Cancer Cell Int, 2020, 20: 473. doi: 10.1186/s12935-020-01549-5
[48]	AKSOY S A, TUNCA B, ERÇELIK M, et al. Early-stage colon cancer with high MALAT1 expression is associated with the 5-Fluorouracil resistance and future metastasis[J]. Mol Biol Rep, 2022, 49(12): 11243-11253. doi: 10.1007/s11033-022-07680-y
[49]	WEI Z Z, ZHOU J, YU H, et al. Zuo Jin Wan reverses the resistance of colorectal cancer to oxaliplatin by regulating the MALAT1/miR-200s/JNK signaling pathway[J]. Evid Based Complement Alternat Med, 2022, 2022: 3032407.
[50]	ZHANG C, YAO K H, ZHANG J J, et al. Long noncoding RNA MALAT1 promotes colorectal cancer progression by acting as a ceRNA of miR-508-5p to regulate RAB14 expression[J]. Biomed Res Int, 2020, 2020: 4157606.
[51]	HUANG B, GUO X B, LI Y. lncRNA MALAT1 regulates the expression level of miR-21 and interferes with the biological behavior of colon cancer cells[J]. J buon, 2020, 25(2): 907-913
[52]	ZHENG H T, SHI D B, WANG Y W, et al. High expression of lncRNA MALAT1 suggests a biomarker of poor prognosis in colorectal cancer[J]. Int J Clin Exp Pathol, 2014, 7(6): 3174-3181.
[53]	LI Q, DAI Y, WANG F, et al. Differentially expressed long non-coding RNAs and the prognostic potential in colorectal cancer[J]. Neoplasma, 2016, 63(6): 977-983. doi: 10.4149/neo_2016_617
[54]	QIU G, ZHANG X B, ZHANG S Q, et al. Dysregulation of MALAT1 and miR-619-5p as a prognostic indicator in advanced colorectal carcinoma[J]. Oncol Lett, 2016, 12(6): 5036-5042. doi: 10.3892/ol.2016.5312
[55]	LI H, ZHANG Y X, LIU Y L, et al. Long noncoding RNA MALAT1 and colorectal cancer: a propensity score analysis of two prospective cohorts[J]. Front Oncol, 2022, 12: 824767. doi: 10.3389/fonc.2022.824767

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Research progress of long non-coding RNA lung adenocarcinoma metastasis-associated transcript 1 in colorectal cancer

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