Value of growth factor combined with uterine artery flow parameters in predicting fetal growth restriction during pregnancy in patients with hypertension

HUANG Qiaoling; WANG Lin

doi:10.7619/jcmp.20231912

Journal of Clinical Medicine in Practice > 2023 > 27(16): 107-110. > DOI: 10.7619/jcmp.20231912

HUANG Qiaoling, WANG Lin. Value of growth factor combined with uterine artery flow parameters in predicting fetal growth restriction during pregnancy in patients with hypertension[J]. Journal of Clinical Medicine in Practice, 2023, 27(16): 107-110. DOI: 10.7619/jcmp.20231912

Citation:

PDF (706 KB)

Value of growth factor combined with uterine artery flow parameters in predicting fetal growth restriction during pregnancy in patients with hypertension

Department of Obstetrics and Gynecology, Zhengzhou Hospital of Traditional Chinese Medicine in Henan Province, Zhengzhou, Henan, 450007

More Information

Received Date: June 13, 2023
Revised Date: July 23, 2023
Available Online: September 05, 2023

Graphical Abstract

Abstract

Abstract

Objective
To investigate the value of growth factor combined with uterine artery blood flow parameters in predicting fetal growth restriction (FGR) in the pregnancy in patients with gestational hypertension.
Methods
A total of 102 women with gestational hypertension were selected and divided into study group (FGR, n=62) and control group (non-FGR, n=40) according to whether FGR occurred. The levels of vascular endothelial growth factor (VEGF) and placental growth factor (PLGF), as well as the ratio of maximum blood flow velocity during systole (S) to end-diastolic blood flow velocity (D) (S/D), resistance index (RI) and pulsation index (PI) were compared between the two groups. The related factors affecting the occurrence of FGR in patients with gestational hypertension were analyzed.
Results
The levels of serum PLGF and VEGF in the study group were significantly lower than those in the control group (P < 0.05). The levels of S/D, PI and RI in the study group were significantly higher than those in the control group (P < 0.05). Increased levels of serum PLGF and VEGF were independent protective factors for FGR in patients with hypertensive pregnancy (P < 0.05); increased S/D, PI and RI were independent risk factors for FGR in patients with hypertensive pregnancy (P < 0.05). The results of receiver operating characteristic (ROC) curve showed that the area under the curve (AUC) of PLGF, VEGF, S/D, PI, RI and combined prediction of FGR in patients with pre-pregnancy hypertension were 0.813, 0.881, 0.883, 0.909, 0.831 and 0.952, respectively.
Conclusion
PLGF and VEGF combined with S/D, PI and RI have a good value in predicting the occurrence of FGR in hypertensive pregnancy.

FullText(HTML)

References (15)

References

[1]	中华医学会妇产科学分会妊娠期高血压疾病学组. 妊娠期高血压疾病诊治指南(2020)[J]. 中华妇产科杂志, 2020, 55(4): 227-238. https://www.cnki.com.cn/Article/CJFDTOTAL-SFCZ202212009.htm
[2]	王莉, 赵霞, 吴莎, 等. 妊娠期高血压疾病300例妊娠结局分析[J]. 中国实用妇科与产科杂志, 2021, 37(5): 588-591. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGSF202105020.htm
[3]	SATO Y. Endovascular trophoblast and spiral artery remodeling[J]. Mol Cell Endocrinol, 2020, 503: 110699. doi: 10.1016/j.mce.2019.110699
[4]	ADDIS D R, LAMBERT J A, REN C C, et al. Vascular endothelial growth factor-121 administration mitigates halogen inhalation-induced pulmonary injury and fetal growth restriction in pregnant mice[J]. J Am Heart Assoc, 2020, 9(3): e013238. doi: 10.1161/JAHA.119.013238
[5]	中华医学会心血管病学分会女性心脏健康学组, 中华医学会心血管病学分会高血压学组. 妊娠期高血压疾病血压管理专家共识(2019)[J]. 中华心血管病杂志, 2020, 48(3): 195-204. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGZ202008008.htm
[6]	中华医学会围产医学分会胎儿医学学组, 中华医学会妇产科学分会产科学组. 胎儿生长受限专家共识(2019版)[J]. 中华围产医学杂志, 2019, 22(6): 361-380. doi: 10.3760/cma.j.issn.1007-9408.2019.06.001
[7]	KHEDAGI A M, BELLO N A. Hypertensive disorders of pregnancy[J]. Cardiol Clin, 2021, 39(1): 77-90. doi: 10.1016/j.ccl.2020.09.005
[8]	李辞妹, 杨颖, 毕晶晶, 等. mTOR和PLGF在胎儿宫内生长受限中的作用机制[J]. 基因组学与应用生物学, 2020, 39(1): 326-331. https://www.cnki.com.cn/Article/CJFDTOTAL-GXNB202001048.htm
[9]	庞静, 聂红艳, 陈伟伟, 等. 妊娠期高血压疾病产妇子宫动脉和胎儿脐动脉超声参数预测妊娠结局的临床价值[J]. 中国计划生育和妇产科, 2019, 11(1): 77-80, 97. https://www.cnki.com.cn/Article/CJFDTOTAL-JHFC201901021.htm
[10]	ZHANG J G, LI J. Efficacy and safety of combination of magnesium sulfate, phentolamine and nifedipine in treatment of patients with hypertensive disorder complicating pregnancy[J]. Exp Ther Med, 2019, 18(5): 3341-3346.
[11]	CAPORALE A, MARTIN A D, CAPASSO D, et al. Short PlGF-derived peptides bind VEGFR-1 and VEGFR-2 in vitro and on the surface of endothelial cells[J]. J Pept Sci, 2019, 25(5): e3146.
[12]	刘佩琳, 马丽丽, 高万里. 血清PLGF、PAPP-A、β-HCG与妊娠期高血压疾病的相关性及预测不良妊娠结局价值[J]. 中国计划生育学杂志, 2022, 30(5): 1154-1158. https://www.cnki.com.cn/Article/CJFDTOTAL-JHSY202205040.htm
[13]	李百玲, 侯丽颖, 王婷, 等. 子宫动脉频谱对妊娠期高血压疾病合并胎儿生长受限的诊断价值研究[J]. 中国妇幼保健, 2020, 35(23): 4599-4602. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB202023062.htm
[14]	CHANDRASEKARAN S, BADELL M L, JAMIESON D J. Management of chronic hypertension during pregnancy[J]. JAMA, 2022, 327(17): 1700-1701.
[15]	LEES C C, STAMPALIJA T, BASCHAT A, et al. ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction[J]. Ultrasound Obstet Gynecol, 2020, 56(2): 298-312.

Cited By

Get Citation

PDF

XML

Article views (110) PDF downloads (3)

Turn off MathJax

Article Contents

Abstract

References

Value of growth factor combined with uterine artery flow parameters in predicting fetal growth restriction during pregnancy in patients with hypertension

Abstract

References

Catalog

Export File

Citation

Format

Content