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ZHUANG Lixia, ZHANG Jie, CHEN Peixin. Application value of serum transforming growth factor-β1 and alkaline phosphatase in diagnosing severe neonatal necrotizing enterocolitis[J]. Journal of Clinical Medicine in Practice, 2023, 27(19): 67-70. DOI: 10.7619/jcmp.20232084
Citation: ZHUANG Lixia, ZHANG Jie, CHEN Peixin. Application value of serum transforming growth factor-β1 and alkaline phosphatase in diagnosing severe neonatal necrotizing enterocolitis[J]. Journal of Clinical Medicine in Practice, 2023, 27(19): 67-70. DOI: 10.7619/jcmp.20232084
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Application value of serum transforming growth factor-β1 and alkaline phosphatase in diagnosing severe neonatal necrotizing enterocolitis

  • Pediatric Department, Shaowu Municipal Hospital of Fujian Province, Shaowu, Fujian, 354000

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  • Received Date: June 29, 2023
  • Revised Date: August 01, 2023
  • Available Online: October 18, 2023
    Graphical Abstract
    • Abstract
  • Objective 

    To investigate the application value of serum transforming growth factor-β1 (TGF-β1) and intestinal alkaline phosphatase (IAP) in the diagnosis of severe neonatal necrotizing small bowel colitis (NEC).

    Methods 

    A total of 82 NEC neonates were selected as NEC group, and were divided into mild group(21 cases), moderate group(43 cases), and severe group(18 cases) according to the modified Bell-NEC stage, and another 80 healthy neonates were selected as control group during the same period. Serum TGF-β1 and IAP levels were detected in each group. The correlations of serum TGF-β1 and IAP levels with Bell-NEC stage were analyzed by Spearman rank correlation, and receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of serum TGF-β1 and IAP levels on NEC in critically ill neonates.

    Results 

    Compared with the control group, serum TGF-β1 and IAP levels were reduced in the NEC group (P<0.05). The serum TGF-β1 and IAP levels of children with NEC in the mild, moderate, and severe groups were reduced sequentially (P<0.05). Spearman's rank correlation analysis showed that serum TGF-β1 and IAP levels in children with NEC stage were negatively correlated with Bell-NEC stage (rs=-0.669, -0.658, P<0.001). ROC curve analysis showed that the area under the curve of serum TGF-β1 and IAP levels alone and their combination in the diagnosis of severe neonatal NEC was 0.783, 0.780, and 0.905, respectively.

    Conclusion 

    Decreased serum TGF-β1 and IAP levels in NEC neonates are associated with severity of disease, and the combined serum TGF-β1 and IAP levels are of high value in the diagnosis of severe neonatal NEC and may be an auxiliary diagnostic index for severe neonatal NEC.

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    • References (21)
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