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ZHU Kairun, XIE Chenglan, YANG Xiaoqian, JIN Wenjie. Research progress of lidocaine in the treatment of cancer pain[J]. Journal of Clinical Medicine in Practice, 2023, 27(22): 131-137. DOI: 10.7619/jcmp.20232163
Citation: ZHU Kairun, XIE Chenglan, YANG Xiaoqian, JIN Wenjie. Research progress of lidocaine in the treatment of cancer pain[J]. Journal of Clinical Medicine in Practice, 2023, 27(22): 131-137. DOI: 10.7619/jcmp.20232163
shu

Research progress of lidocaine in the treatment of cancer pain

  • 1.

    Nanjing Medical University, Nanjing, Jiangsu, 211166

  • 2.

    Department of Anesthesiology, Huai'an Hospital Affiliated to Xuzhou Medical University, Huai'an, Jiangsu, 223002

  • 3.

    Department of Anesthesiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029

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  • Received Date: July 05, 2023
  • Revised Date: September 05, 2023
  • Available Online: December 05, 2023
    Graphical Abstract
    • Abstract

  • Pain permeates the entire process of cancer, and its mechanism is complex, involving tumor microenvironment, cancer-related bone pain, cancer-related visceral pain, cancer-related neuropathic pain, and surgery and radiotherapy-related factors. Studies have indicated that lidocaine can alleviate intractable cancer pain for opioids, and its mechanism of action in treating various types of cancer pain may also be different, involving the regulation of acid-sensing ion channels (ASICS), transient receptor potential channels (TRP), voltage-gated sodium channels (VGSCs), nerve growth factor (NGF), glutamate and its receptors, inflammatory cells and cytokines, microglia, astrocytes, and high mobility group box 1 protein (HMGB1). This paper reviewed the mechanisms of cancer pain, the mechanisms of lidocaine in treating different types of cancer pain as well as its clinical applications.

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