Citation: | QIU Ye, YANG Xiaoqian, CAO Yachuan, CUI Ying. Influencing factors and predictive model construction of recurrence within one year after discontinuation of medication in children with cough variant asthma after regular treatment[J]. Journal of Clinical Medicine in Practice, 2023, 27(24): 42-47. DOI: 10.7619/jcmp.20232424 |
To analyze the influencing factors of recurrence within one year after discontinuation of regular treatment of children's cough variant asthma (CVA) and to construct a predictive model, in order to provide guidance for doctors to evaluate the risk of recurrence after CVA treatment in children and develop prevention strategies.
A total of 215 children with CVA were selected as the study objects. According to whether recurrence occurred within one year after discontinuation of regular treatment, the patients were divided into recurrence group (n=89) and non-recurrence group (n=126). Data of two groups were collected for univariate and multivariate Logistic regression analysis to screen out the influencing factors of recurrence in children with CVA. The GBM prediction model was constructed by using R software to run the gradient boosting model (GBM) algorithm. Receiver operating characteristic (ROC) curve was used to analyze and compare the predictive efficiency of GBM model and Logistic regression model.
The recurrence rate of 215 children with CVA within one year after regular treatment was 41.40%(89/215). Allergy history (OR=2.870, 95%CI, 1.442 to 5.714), repeated respiratory infection history (OR=4.132, 95%CI, 2.045 to 8.348), parents' cognitive level of CVA prevention and control (OR=1.063, 95%CI, 1.011 to 1.118), eosinophils (OR=0.801, 95%CI, 0.674 to 0.952), forced expiratory flow at 50% of vital capacity (FEF50) (OR=1.055, 95%CI, 1.012 to 1.099), maximal midexpiratory flow rate 75/25 (MMEF75/25) (OR=1.054, 95%CI, 1.009 to 1.102), and fractional exhaled nitric oxide (FeNO) (OR=0.883, 95%CI, 0.834 to 0.935) were influencing factors for recurrence within one year after regular treatment of children's CVA (P < 0.05). According to ROC curve analysis, the area under the curve of GBM model was 0.872, which was larger than 0.827 of Logistic regression model.
GBM prediction model is established based on the influencing factors of recurrence within one year after regular treatment of CVA in children, which can be used as a reference for clinical measures to prevent recurrence in children after treatment of CVA.
[1] |
中华医学会儿科学分会呼吸学组慢性咳嗽协作组, 《中华儿科杂志》编辑委员会. 中国儿童慢性咳嗽诊断与治疗指南(2013年修订)[J]. 中华儿科杂志, 2014, 52(3): 184-188.
|
[2] |
MORICE A H, MILLQVIST E, BIEKSIENE K, et al. ERS guidelines on the diagnosis and treatment of chronic cough in adults and children[J]. Eur Respir J, 2020, 55(1): 1901136. doi: 10.1183/13993003.01136-2019
|
[3] |
O′GRADY K F, GRIMWOOD K, TORZILLO P J, et al. Effectiveness of a chronic cough management algorithm at the transitional stage from acute to chronic cough in children: a multicenter, nested, single-blind, randomised controlled trial[J]. Lancet Child Adolesc Health, 2019, 3(12): 889-898. doi: 10.1016/S2352-4642(19)30327-X
|
[4] |
YI F, HAN L N, LIU B J, et al. Determinants of response to bronchodilator in patients with cough variant asthma- A randomized, single-blinded, placebo-controlled study[J]. Pulm Pharmacol Ther, 2020, 61: 101903. doi: 10.1016/j.pupt.2020.101903
|
[5] |
张会娟, 刘毅, 钱效森, 等. 支气管哮喘患者小气道功能障碍预测因素分析[J]. 医学综述, 2022, 28(9): 1852-1856.
|
[6] |
袁馥梅, 韩玉霞, 高娜, 等. 趣味性健康教育对学龄期哮喘患儿认知水平及治疗依从性的影响[J]. 中国健康教育, 2020, 36(12): 1149-1151.
|
[7] |
宋小秀, 王凌啸, 任艳霞. 学龄前儿童家长呼吸道保健知识认知水平及影响因素[J]. 江苏预防医学, 2020, 31(6): 712-714.
|
[8] |
万敏, 张巧, 傅银, 等. 影响咳嗽变异型哮喘预后的高危因素分析[J]. 第三军医大学学报, 2020, 42(2): 176-180.
|
[9] |
陈辉军. 维生素D水平与小儿咳嗽变异性哮喘后复发风险的关系[J]. 中国妇幼保健, 2022, 37(17): 3123-3126.
|
[10] |
LI W, BAN C F, ZHANG J X, et al. Correlation study of cough variant asthma and mycoplasma pneumonia infection in children[J]. Pak J Pharm Sci, 2017, 30(3 Special): 1099-1102.
|
[11] |
王傲杰, 刘长山. 哮喘儿童吸入性糖皮质激素规范治疗停药后复发相关因素的分析[J]. 实用药物与临床, 2018, 21(5): 536-540.
|
[12] |
ENSEKI M, NUKAGA M, TADAKI H, et al. A breath sound analysis in children with cough variant asthma[J]. Allergol Int, 2019, 68(1): 33-38. doi: 10.1016/j.alit.2018.05.003
|
[13] |
PISI R, TZANI P, AIELLO M, et al. Small airway dysfunction by impulse oscillometry in asthmatic patients with normal forced expiratory volume in the 1st second values[J]. Allergy Asthma Proc, 2013, 34(1): e14-e20. doi: 10.2500/aap.2013.34.3641
|
[14] |
晁婵. 胸腺基质淋巴细胞生成素联合小气道肺功能指标诊断儿童咳嗽变异性哮喘的临床价值[J]. 中国免疫学杂志, 2023, 39(7): 1490-1493. doi: 10.3969/j.issn.1000-484X.2023.07.027
|
[15] |
YI F, JIANG Z Y, LI H, et al. Small airway dysfunction in cough variant asthma: prevalence, clinical, and pathophysiological features[J]. Front Physiol, 2021, 12: 761622.
|
[16] |
CHEN F J, HUANG X Y, LIN G P, et al. Validity of fractional exhaled nitric oxide and small airway function indices in diagnosis of cough-variant asthma[J]. J Asthma, 2018, 55(7): 750-755. doi: 10.1080/02770903.2017.1366509
|
[17] |
左丹华, 王丹, 邵楠, 等. 呼出气一氧化氮联合小气道功能检查对小儿咳嗽变异性哮喘与感染后咳嗽引起的慢性咳嗽的鉴别诊断价值[J]. 中国医药导报, 2023, 20(14): 98-101.
|
[18] |
YUAN H L, LIU X J, LI L, et al. Clinical and pulmonary function changes in cough variant asthma with small airway disease[J]. Allergy Asthma Clin Immunol, 2019, 15: 41. doi: 10.1186/s13223-019-0354-1
|
[19] |
王洁, 王丹丹, 潘永, 等. 嗜酸性粒细胞、白细胞介素-23/Th17轴及小气道功能与小儿咳嗽变异性哮喘的相关性分析[J]. 安徽医药, 2021, 25(3): 537-540. doi: 10.3969/j.issn.1009-6469.2021.03.026
|
[20] |
GAO J, WU H G, WU F. Small airway dysfunction in patients with cough variant asthma: a retrospective cohort study[J]. BMC Pulm Med, 2021, 21(1): 49. doi: 10.1186/s12890-021-01419-4
|
[21] |
黄良龙, 张利诚, 王涛, 等. 咳嗽变异性哮喘患儿血miR-34a表达水平与免疫失衡状态和炎症反应的关系研究[J]. 浙江医学, 2023, 45(7): 713-716, 722.
|
[22] |
蒋国路, 陈小菊, 蒋莉, 等. 呼出气一氧化氮联合肺功能及外周血嗜酸性粒细胞比例检测在咳嗽变异性哮喘诊断中的价值[J]. 解放军医学杂志, 2022, 47(5): 486-492.
|
[23] |
李芮, 董晓艳, 蒋鲲, 等. 口鼻呼出气一氧化氮检测在儿童支气管哮喘控制评估及过敏性鼻炎诊断中的应用[J]. 中国当代儿科杂志, 2022, 24(1): 90-95.
|
[24] |
汪静, 郑丽颖, 李卓隽, 等. 血清25羟维生素D3与IgE联合FeNO检测对咳嗽变异性哮喘的预后评价[J]. 西部医学, 2018, 30(10): 1484-1487.
|
[25] |
ZHU H Y, ZHANG R R, HAO C L, et al. Fractional exhaled nitric oxide (FeNO) combined with pulmonary function parameters shows increased sensitivity and specificity for the diagnosis of cough variant asthma in children[J]. Med Sci Monit, 2019, 25: 3832-3838.
|