Objective To investigate the effects of Danshen polyphenolate combined with edaravone on cognitive function, cerebral artery pulse index(PIMCA) and serum trypanoprotein-like protein-1 (VILIP-1) levels in patients with acute cerebral infarction(ACI).
Methods A total of 88 patients with ACI were selected as study objects. The patients were divided into single drug group (n=44) and combination group (n=44) according to random number table method. The single drug group was treated with edaravone, and the combination group was treated with edaravone combined with salvianolic acid for injection. The efficacy, cognitive function, PIMCA and serum VILIP-1 levels of the two groups were observed and compared.
Results The overall effective rate of treatment in the combination group was higher than that of the single drug group (81.82% versus 54.55%, P < 0.05). After treatment, the scores of Montreal Cognitive Assessment Scale (MoCA), Reactivity Exploration Scale (RSS) and Simple Mental State Assessment Scale (MMSE) in two groups were higher than before treatment, and the combination group was higher than the single drug group(P < 0.05). After treatment, the levels of PIMCA and serum VILIP-1 in two groups were lower than before treatment, and the combination group was lower than the single drug group (P < 0.05).
Conclusion Compared with edaravone alone, salvia miltiorrhiza polyphenolate injection combined with edaravone has a better therapeutic effect in ACI patients, which can effectively improve the patients' cognition, reduce PIMCA and serum VILIP-1 levels.
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