Predictive value of serum microRNA-506 and microRNA-934 levels in postoperative survival outcome of patients with pancreatic cancer

Objective To investigate the predictive value of serum microRNA-506 (miR-506) and microRNA-934 (miR-934) expression levels in postoperative survival outcomes of patients with pancreatic cancer.

Methods A total of 115 patients with pancreatic cancer who received surgical treatment were selected as the study group, and were divided into survival group (n=18) and death group (n=97) according to the follow-up results. Fifty patients with benign pancreatic lesions in the same period were selected as control group; fifty healthy volunteers were selected as the healthy group. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the relative expression levels of miR-506 and miR-934 in serum of each group. Multivariate Logistic regression analysis was used to analyze the influencing factors of postoperative survival outcomes in patients with pancreatic cancer. The predictive value of serum miR-506 and miR-934 in postoperative survival outcome of pancreatic cancer patients was analyzed by receiver operating characteristic (ROC) curve.

Results The expression level of serum miR-506 in the study group was significantly lower than that in the control group (P < 0.05). The expression level of serum miR-934 in the study group was significantly higher than that in the control group and healthy group (P < 0.05). The expression level of serum miR-506 in the survival group was significantly higher than that in the death group, and the expression level of serum miR-934 was significantly lower than that in the death group (P < 0.05). The miR-506, miR-934, TNM stage and lymph node metastasis were independent factors influencing postoperative survival of pancreatic cancer patients (P < 0.05).

Conclusion The expression of miR-506 is low in the serum of patients who died after pancreatic cancer surgery, and the expression of miR-934 is high in the serum of patients who died after pancreatic cancer surgery. The value of miR-506 and miR-934 in predicting postoperative survival outcome of pancreatic cancer patients is high.