Effect of a new type of ampelopsis hydrogel on gouty arthritis with accumulation of dampness-heat syndrome

XU Meimei; GUO Liang; CHEN Yueyue; JING Rongyue; ZHU Yamei; XU Dake; HE Jing; XU Bo; ZHOU Yan; XU Lei

doi:10.7619/jcmp.20233058

Journal of Clinical Medicine in Practice > 2024 > 28(5): 25-30. > DOI: 10.7619/jcmp.20233058

XU Meimei, GUO Liang, CHEN Yueyue, JING Rongyue, ZHU Yamei, XU Dake, HE Jing, XU Bo, ZHOU Yan, XU Lei. Effect of a new type of ampelopsis hydrogel on gouty arthritis with accumulation of dampness-heat syndrome[J]. Journal of Clinical Medicine in Practice, 2024, 28(5): 25-30. DOI: 10.7619/jcmp.20233058

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Effect of a new type of ampelopsis hydrogel on gouty arthritis with accumulation of dampness-heat syndrome

Department of Rheumatology, Nanjing Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, 210006

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Received Date: September 24, 2023
Revised Date: November 01, 2023
Available Online: March 21, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the interventional effect and mechanism of a novel ampelopsis hydrogel on dampness-heat accumulation syndrome of gouty arthritis.
Methods
A total of 90 patients with gouty arthritis who met the diagnostic criteria of western medicine and were differentiated as damp-heat accumulation syndrome of traditional Chinese medicine(TCM) were randomly divided into treatment group, control group and blank group, with 30 patients in each group. The blank group was treated with etoricoxib only, the control group was treated with etoricoxib combined with ampelopsis hydrogel, and the treatment group was treated with etoricoxib combined with external application of ampelopsis hydrogel. The clinical efficacy, time to symptom improvement, safety, comfort, changes in syndrome scores of TCM, serum inflammatory factors[C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), erythrocyte sedimentation rate (ESR)], NF-κB signaling pathway-related proteins, Visual Analogue Scale (VAS) scores for pain, and joint mobility were compared among the three groups before and after treatment.
Results
The total effective rates in the treatment group and control group were 93.33% and 90.00%, respectively, which were higher than 70.00% in the blank group (P < 0.05). The time for improvement of pain, redness, tenderness, and limited joint mobility in the treatment group was shorter than that in the control group and blank group (P < 0.05). After 7 days of treatment, the TCM syndrome score in the treatment group was lower than that in the control group and blank group, and the levels of serum CRP, TNF-α, and ESR and the expressions of NF-κB signalingpathway-related proteins P50 and P65 in the treatment group and control group were lower than those in the blank group (P < 0.05). After 7 days of treatment, the VAS score in the treatment group was lower than that in the control group and blank group, and the comfort score in the treatment group was higher than that in the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions among the three groups (P>0.05).
Conclusion
The effect of ampelopsis hydrogel in treating gouty arthritis is better than that of ampelopsis paste, and its mechanism may be related to the regulation of the NF-κB pathway and inhibition of inflammatory factor expression. The hydrogel is easy to use, hygienic, and comfortable, and is expected to become a safe, effective, and convenient external medicine for gouty arthritis.
- ampelopsis hydrogel,
- dampness-heat accumulation syndrome,
- gout,
- arthritis

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References (18)

References

[1]	GALOZZI P, BINDOLI S, DORIA A, et al. Autoinflammatory features in gouty arthritis[J]. J Clin Med, 2021, 10(9): 1880. doi: 10.3390/jcm10091880
[2]	刘英, 张国, 刘洁. 祛风止痛汤内服和止痛外敷方外敷治疗急性痛风性关节炎疗效及对血清促炎因子的影响[J]. 现代中西医结合杂志, 2020, 29(16): 1777-1780. https://www.cnki.com.cn/Article/CJFDTOTAL-XDJH202016017.htm
[3]	曾成永, 曹传敏, 刘家荣, 等. 乌蔹莓膏联合负压辅助治疗对高位复杂性肛瘘术后创面愈合的影响[J]. 中国现代普通外科进展, 2020, 23(6): 491-493. https://www.cnki.com.cn/Article/CJFDTOTAL-PWJZ202006023.htm
[4]	LIN Y Q, LUO T Y, WENG A L, et al. Gallic acid alleviates gouty arthritis by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling[J]. Front Immunol, 2020, 11: 580593. doi: 10.3389/fimmu.2020.580593
[5]	LIN X Y, SHAO T J, HUANG L, et al. Simiao decoction alleviates gouty arthritis by modulating proinflammatory cytokines and the gut ecosystem[J]. Front Pharmacol, 2020, 11: 955. doi: 10.3389/fphar.2020.00955
[6]	郑雪平, 王业皇, 樊志敏, 等. 乌蔹莓膏治疗高位复杂性肛瘘术后创面的临床观察[J]. 中国药房, 2016, 27(32): 4534-4536. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYA201632023.htm
[7]	许倩倩, 包贝华, 张丽, 等. UPLC-QTOF-MS分析乌蔹莓成分及多组分定量研究[J]. 南京中医药大学学报, 2020, 36(4): 517-524. https://www.cnki.com.cn/Article/CJFDTOTAL-NJZY202004019.htm
[8]	髙瞾, 冉颖卓. 乌蔹莓软膏外敷对痛风急性关节炎期湿热蕴结型持续时间和疼痛程度的影响[J]. 甘肃中医, 2009, 22(12): 20-21. https://www.cnki.com.cn/Article/CJFDTOTAL-GSZY200912015.htm
[9]	宋彩霞. 中药外敷治疗急性痛风性关节炎48例[J]. 世界中西医结合杂志, 2012, 7(2): 142-144. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZX201202017.htm
[10]	GUO X X, HAO H H, MENG A X, et al. Analysis of Acanthopanax giraldii harms polysaccharide Ⅱ composition and its immune-protective role in a cyclophosphamide-induced immunosuppressive mice model[J]. Evid Based Complement Alternat Med, 2021, 2021: 3387396.
[11]	HUANG X F, GU R, ZHONG S H, et al. Reproductive characteristics and habitat factors of Acanthopanax giraldii[J]. China J Chin Mater Med, 2019, 44(9): 1781-1788.
[12]	朱凌云, 许倩倩, 包贝华, 等. 乌蔹莓不同提取物软膏对急性痛风性关节炎模型大鼠的治疗作用及其机制研究[J]. 江苏中医药, 2021, 53(10): 74-78. https://www.cnki.com.cn/Article/CJFDTOTAL-JSZY202110024.htm
[13]	候冰娜, 郑泽邻, 赵梓年, 等. 可注射海藻酸钠/泊洛沙姆复合水凝胶的制备及药物缓释研究[J]. 材料工程, 2020, 48(12): 60-67. https://www.cnki.com.cn/Article/CJFDTOTAL-CLGC202012008.htm
[14]	HAIKAL S M, ABDELTAWAB N F, RASHED L A, et al. Combination therapy of mesenchymal stromal cells and interleukin-4 attenuates rheumatoid arthritis in a collagen-induced murine model[J]. Cells, 2019, 8(8): 823. doi: 10.3390/cells8080823
[15]	刘亚飞, 陈哲, 涂胜豪. 加味四妙方对高尿酸血症合并急性痛风性关节炎模型大鼠踝关节组织NLRP3 mRNA及IL-1β、TNF-α表达的影响[J]. 中医杂志, 2020, 61(14): 1268-1272. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ202014019.htm
[16]	熊逸晨, 吴瀚枫, 张恩婷, 等. 葛根素对急性痛风性关节炎大鼠TLR4/NF-κB通路的影响[J]. 中国现代医学杂志, 2020, 30(7): 14-18. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXDY202007005.htm
[17]	XIE M X, WANG J Z, GONG W, et al. NF-κB-driven miR-34a impairs Treg/Th17 balance via targeting Foxp3[J]. J Autoimmun, 2019, 102: 96-113. doi: 10.1016/j.jaut.2019.04.018
[18]	ZHAO C Y, WANG Q, TAO X X, et al. Multimodal photoacoustic/ultrasonic imaging system: a promising imaging method for the evaluation of disease activity in rheumatoid arthritis[J]. Eur Radiol, 2021, 31(5): 3542-3552. doi: 10.1007/s00330-020-07353-z

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Effect of a new type of ampelopsis hydrogel on gouty arthritis with accumulation of dampness-heat syndrome

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