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BAO Huanli, WEI Wei, XU Chao, WANG Jianpeng, TONG Jin. Effect of Zhongtong'an Capsules combined with rivaroxaban tables in treating deep venous thrombosis of lower extremities after total knee arthroplasty[J]. Journal of Clinical Medicine in Practice, 2024, 28(11): 68-72. DOI: 10.7619/jcmp.20233098
Citation: BAO Huanli, WEI Wei, XU Chao, WANG Jianpeng, TONG Jin. Effect of Zhongtong'an Capsules combined with rivaroxaban tables in treating deep venous thrombosis of lower extremities after total knee arthroplasty[J]. Journal of Clinical Medicine in Practice, 2024, 28(11): 68-72. DOI: 10.7619/jcmp.20233098
shu

Effect of Zhongtong'an Capsules combined with rivaroxaban tables in treating deep venous thrombosis of lower extremities after total knee arthroplasty

  • 1.

    Ward of Knee Joint Diseases, Honghui Hospital Affiliatedto Xi'an Jiaotong University, Xi'an, Shaanxi, 710054

  • 2.

    Department of Foot and Ankle Surgery, Honghui Hospital Affiliatedto Xi'an Jiaotong University, Xi'an, Shaanxi, 710054

More Information
  • Received Date: September 26, 2023
  • Revised Date: February 26, 2024
  • Available Online: June 17, 2024
    Graphical Abstract
    • Abstract
  • Objective 

    To observe the effect of Zhongtong'an Capsules combined with rivaroxaban tablets on deep venous thrombosis (DVT) of lower extremities after total knee arthroplasty.

    Methods 

    A total of 82 patients were randomly divided into control group and experimental group, with 41 cases in each group. The control group was treated with rivaroxaban tablets after surgery, while the experimental group was treated with oral administration of Zhongtong'an Capsules on the basis of the control group. The main outcome indicators (occurrence of DVT of lower extremities), secondary outcome indicators[circumference of lower extremities, blood flow velocity of femoral deep vein, whole blood high shear viscosity, whole blood low shear viscosity, hematocrit, plasma viscosity index, serum prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), and plasma D-dimer (D-D)], and therapeutic effects[the Visual Analogue Scale (VAS) score for pain, score of American Hospital for Special Surgery (HSS) forknee function]were compared between the two groups.

    Results 

    After 14 days of treatment, the incidence of DVT of lower extremities in the experimental group was 9.76% (4/41), which was significantly lower than 31.71%(13/41) in the control group (χ2=6.011, P < 0.05). Compared with the control group, the experimental group had faster venous blood flow velocity and reduced circumference of lower extremities after 7 and 14 days of treatment (P < 0.05). After 7 and 14 days of treatment, all the hemorheological-related indicators in the experimental group were significantly lower than those in the control group (P < 0.05). After 7 and 14 days of treatment, the PT and APTT in the experimental group were significantly longer than those in the control group, while the FIB and D-D levels were significantly lower than those in the control group (P < 0.05). After 7 and 14 days of treatment, the VAS scores decreased and the HSS scores increased significantly in both groups, and the VAS scores in the experimental group were significantly lower than those in the control group, while the HSS scores were significantly higher than those in the control group (P < 0.05).

    Conclusion 

    Zhongtong'an Capsules combined with rivaroxaban tablets can effectively improve the hypercoagulable state of patients after knee arthroplasty and reduce the formation of postoperative DVT.

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    • References (21)
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