| Citation: |
BAO Huanli, WEI Wei, XU Chao, WANG Jianpeng, TONG Jin. Effect of Zhongtong'an Capsules combined with rivaroxaban tables in treating deep venous thrombosis of lower extremities after total knee arthroplasty[J]. Journal of Clinical Medicine in Practice, 2024, 28(11): 68-72. DOI: 10.7619/jcmp.20233098
|
To observe the effect of Zhongtong'an Capsules combined with rivaroxaban tablets on deep venous thrombosis (DVT) of lower extremities after total knee arthroplasty.
A total of 82 patients were randomly divided into control group and experimental group, with 41 cases in each group. The control group was treated with rivaroxaban tablets after surgery, while the experimental group was treated with oral administration of Zhongtong'an Capsules on the basis of the control group. The main outcome indicators (occurrence of DVT of lower extremities), secondary outcome indicators[circumference of lower extremities, blood flow velocity of femoral deep vein, whole blood high shear viscosity, whole blood low shear viscosity, hematocrit, plasma viscosity index, serum prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), and plasma D-dimer (D-D)], and therapeutic effects[the Visual Analogue Scale (VAS) score for pain, score of American Hospital for Special Surgery (HSS) forknee function]were compared between the two groups.
After 14 days of treatment, the incidence of DVT of lower extremities in the experimental group was 9.76% (4/41), which was significantly lower than 31.71%(13/41) in the control group (χ2=6.011, P < 0.05). Compared with the control group, the experimental group had faster venous blood flow velocity and reduced circumference of lower extremities after 7 and 14 days of treatment (P < 0.05). After 7 and 14 days of treatment, all the hemorheological-related indicators in the experimental group were significantly lower than those in the control group (P < 0.05). After 7 and 14 days of treatment, the PT and APTT in the experimental group were significantly longer than those in the control group, while the FIB and D-D levels were significantly lower than those in the control group (P < 0.05). After 7 and 14 days of treatment, the VAS scores decreased and the HSS scores increased significantly in both groups, and the VAS scores in the experimental group were significantly lower than those in the control group, while the HSS scores were significantly higher than those in the control group (P < 0.05).
Zhongtong'an Capsules combined with rivaroxaban tablets can effectively improve the hypercoagulable state of patients after knee arthroplasty and reduce the formation of postoperative DVT.
| [1] |
XIONG X J, LI T, YU S, et al. Association between low serum albumin and preoperative deep vein thrombosis in patients undergoing total joint arthroplasty: a retrospective study[J]. Clin Appl Thromb Hemost, 2023, 29: 10760296231178547.
|
| [2] |
LUTSEY P L, ZAKAI N A. Epidemiology and prevention of venous thromboembolism[J]. Nat Rev Cardiol, 2023, 20(4): 248-262. doi: 10.1038/s41569-022-00787-6
|
| [3] |
HECKMANN N D, PIPLE A S, WANG J C, et al. Aspirin for venous thromboembolic prophylaxis following total hip and total knee arthroplasty: an analysis of safety and efficacy accounting for surgeon selection bias[J]. J Arthroplasty, 2023, 38(7 Suppl 2): S412-S419, e1.
|
| [4] |
董小亚. 肿痛安胶囊联合米诺环素治疗慢性牙周炎疗效及对患者血清学指标的影响分析[J]. 医学理论与实践, 2021, 34(4): 640-641. https://www.cnki.com.cn/Article/CJFDTOTAL-YXLL202104051.htm
|
| [5] |
李冰玥, 张晞倩, 吴娟, 等. 肿痛安胶囊治疗风痰瘀血阻络型KOA的疗效及其对关节滑液中IL-1β、OPN及血液流变学的影响[J]. 川北医学院学报, 2022, 8(7): 875-878. doi: 10.3969/j.issn.1005-3697.2022.07.012
|
| [6] |
王鹏, 崔书国, 国延军, 等. 肿痛安胶囊对风痰瘀血阻络型膝骨关节炎关节滑液中骨桥蛋白表达的影响[J]. 中国中医基础医学杂志, 2014, 20(2): 217, 230. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJC201402035.htm
|
| [7] |
成永忠, 王鹏, 赵继阳, 等. 肿痛安胶囊治疗风痰瘀血阻络型膝骨关节炎临床对照研究[J]. 中国中医基础医学杂志, 2012, 18(2): 181-182. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJC201202027.htm
|
| [8] |
中华医学会骨科学分会关节外科学组. 骨关节炎诊疗指南(2018年版)[J]. 中华骨科杂志, 2018, 38(12): 11. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYZG202306001.htm
|
| [9] |
中华医学会外科学分会血管外科学组. 深静脉血栓形成的诊断和治疗指南(第三版)[J]. 中国血管外科杂志: 电子版, 2017, 9(4): 250-257. https://www.cnki.com.cn/Article/CJFDTOTAL-XGWK201704005.htm
|
| [10] |
赵海荣, 王清敏. 独活寄生合剂加肿痛安治疗膝骨性关节炎122例[J]. 中国社区医师: 医学专业, 2012, 14(36): 10. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGSQ201236006.htm
|
| [11] |
齐立卿, 焦永伟, 任伟亮. 肿痛安胶囊联合双氯芬酸钠治疗膝关节骨性关节炎疗效观察[J]. 中国中医药信息杂志, 2012, 19(9): 80-81. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY201209033.htm
|
| [12] |
汪炜. 肿痛安胶囊与独一味胶囊治疗痰血瘀滞型膝骨关节炎的临床效果对比分析[J]. 中国现代药物应用, 2013, 7(20): 139-140. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY201320119.htm
|
| [13] |
陈斌, 王峰, 李文华. 肿痛安胶囊治疗风湿性关节炎的临床研究[J]. 河北医药, 2013, 35(22): 3499-3500. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYZ201322081.htm
|
| [14] |
TATEIWA T, ISHIDA T, MASAOKA T, et al. Clinical course of asymptomatic deep vein thrombosis after total knee arthroplasty in Japanese patients[J]. J Orthop Surg (Hong Kong), 2019, 27(2): 2309499019848095.
|
| [15] |
党德军, 刘喜军, 王甲鹏, 等. 自拟益气活络方联合利伐沙班片预防髋关节置换术后下肢深静脉血栓形成的临床效果[J]. 环球中医药, 2016, 9(11): 1371-1374. https://www.cnki.com.cn/Article/CJFDTOTAL-HQZY201611027.htm
|
| [16] |
王田田, 李海燕, 苏晴晴, 等. 多学科协作延续护理对全膝关节置换术老年患者肢体肿胀及皮温的影响[J]. 护理管理杂志, 2020, 20(4): 299-304. https://www.cnki.com.cn/Article/CJFDTOTAL-HLGL202004022.htm
|
| [17] |
张付祥. 腕踝针联合中药外敷对行全膝关节置换术患者术后疼痛及功能康复的影响[J]. 中国疗养医学, 2021, 30(1): 61-63. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGLX202101024.htm
|
| [18] |
XIONG F J, ZHAO W, JIA S J, et al. Effect of oral pre-emptive analgesia on pain management after total knee arthroplasty: a protocol for systematic review and meta-analysis[J]. BMJ Open, 2023, 13(3): e070998.
|
| [19] |
徐卫东, 陈正, 吴滢, 等. 强筋壮骨方联合硫酸氨基葡萄糖胶囊治疗膝骨性关节炎临床研究[J]. 中华中医药杂志, 2018, 33(4): 1663-1665. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201804126.htm
|
| [20] |
DAI X Y, CHEN K, HUANG Z H, et al. Predictive value of preoperative erythrocyte electrophoresis exponent for acute deep vein thrombosis after total knee arthroplasty in patients with knee osteoarthritis[J]. J Orthop Surg Res, 2020, 15(1): 496.
|
| [21] |
ZHAO Z J, TIAN Q F, ZHANG B Y. Effects of rehabilitation nursing care on deep vein thrombosis of the lower limbs following spinal fractures[J]. Am J Transl Res, 2021, 13(3): 1877-1883.
|
| 1. |
张向前，兰堃田，李伟明. 外周血循环肿瘤细胞动态变化与晚期食管癌化疗患者预后的关系. 医药论坛杂志. 2024(21): 2261-2265 .
|
© 2020 《实用临床医药杂志》编辑部
Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807
Supported by:
Beijing Renhe Information Technology Co., Ltd.
苏公网安备 32100302010246号
DownLoad: