Relationships of 25-hydroxyvitamin D, human β-defencin-2 and insulin-like growth factor 1 levels with disease severity in acne patients

YANG Yueyi; LIN Xia; WANG Libing

doi:10.7619/jcmp.20233195

Journal of Clinical Medicine in Practice > 2024 > 28(16): 60-64. > DOI: 10.7619/jcmp.20233195

YANG Yueyi, LIN Xia, WANG Libing. Relationships of 25-hydroxyvitamin D, human β-defencin-2 and insulin-like growth factor 1 levels with disease severity in acne patients[J]. Journal of Clinical Medicine in Practice, 2024, 28(16): 60-64. DOI: 10.7619/jcmp.20233195

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Relationships of 25-hydroxyvitamin D, human β-defencin-2 and insulin-like growth factor 1 levels with disease severity in acne patients

Department of Dermatology, the First Hospital of Qinhuangdao City in Hebei Province, Qinhuangdao, Hebei, 066000

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Received Date: October 09, 2023
Revised Date: December 03, 2023

Graphical Abstract

Abstract

Abstract

Objective
To investigate the correlations of levels of 25-hydroxyvitamin D[25(OH) D], human β-defencin-2 (HBD-2) and insulin-like growth factor 1(IGF-1) in peripheral blood with disease severity of acne patients.
Methods
A total of 128 patients with acne vulgaris were included in the acne group and 128 healthy subjects were included in the control group. The levels of 25(OH) D, HBD-2 and IGF-1 in peripheral blood of two groups were detected. The relationships between the levels of 25(OH) D, HBD-2, IGF-1 in peripheral blood and the disease severity of acne patients were analyzed. The relationships between 25(OH) D, HBD-2 and IGF-1 levels in peripheral blood of acne patients were analyzed. The diagnostic value of 25(OH) D, HBD-2 and IGF-1 levels in severe acne was evaluated using receiver operating characteristic (ROC) curves.
Results
The level of 25(OH) D in peripheral blood of the acne group was significantly lower than that of the control group, and the level of IGF-1 was significantly higher than that of the control group (P < 0.05). There was no significant difference in HBD-2 levels between the two groups (P>0.05). In the acne group, with the aggravation of disease severity, the level of 25(OH) D in peripheral blood was significantly decreased, and the level of IGF-1 was significantly increased (P < 0.05). The level of 25(OH) D in peripheral blood of acne patients was negatively correlated with the level of IGF-1 and the severity of the disease (r=-0.509, -0.586, P < 0.05), and the level of IGF-1 was positively correlated with the severity of the disease (r=0.547, P < 0.05). HBD-2 level was not correlated with 25(OH) D, IGF-1 level and disease severity (P>0.05). The sensitivity of peripheral blood 25(OH) D level and IGF-1 level in evaluating severity acne was 94.12%, 61.26%, respectively, and the specificity was 70.59%, 77.48%, respectively. The sensitivity and specificity of combined evaluation of severe acne were 90.91% and 71.43%, respectively.
Conclusion
The level of 25(OH) D is decreased and the level of IGF-1 is increased in patients with acne, which is related to the severity of the disease. The combination of 25(OH) D and IGF-1 levels has a better efficacy in evaluating severity acne.
- acne,
- 25-hydroxyvitamin D,
- human β-defensin-2,
- insulin-like growth factor 1,
- severity of disease

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References (28)

References

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Relationships of 25-hydroxyvitamin D, human β-defencin-2 and insulin-like growth factor 1 levels with disease severity in acne patients

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