Risk prevention and oral care in patients with gingival bleeding caused by oral administration of warfarin

Objective To observe effect of TCM oral care solution in patients with gingival bleeding caused by oral administration of warfarin.

Methods A total of 150 hospitalized patients in the cardiology department were selected as study objects, and were randomly divided into control group 1, control group 2 and experimental group, with 50 patients per group. Patients in the three groups were given medication care of warfarin and health guidance for mouth care. The control group 1 increased the use of normal saline gargle; the control group 2 increased the use of silver ion gargle, and the experimental group was given the use of traditional Chinese medicine oral care solution gargle. After the intervention, the number of gingival bleeding, gingival sulcus bleeding index (SBI) and halitosis score in the three groups were compared.

Results The number of gingival bleeding during gargling (10 d) and within 4 weeks after discharge in the experimental group were less than that in the control group 1 and control group 2, the difference was statistically significant (P < 0.05). The SBI of the experimental group was (1.53±0.69), which was lower than (2.12±0.79) in the control group 1 and (2.09±0.76) in the control group 2 (P < 0.05). The score of halitosis during gargling in the experimental group was (1.70±0.68), which was lower than (2.28±0.74) in the control group 1 and (2.23±0.79) in the control group 2 (P < 0.05).

Conclusion The TCM oral care solution for patients with gingival bleeding caused by oral administration of warfarin can significantly reduce the number of gingival bleeding, reduce SBI, alleviate bad breath, improve oral health and drug safety.