Objective To investigate the predictive efficiency of combined uterine artery hemodynamic parameters and oxidative stress indicators in early pregnancy on hypertensive diseases in pregnancy (HDP).
Methods A total of 90 HDP patients (case group) and 30 healthy pregnant women (control group) as research subjects. The case group included 30 patients with pregnancy-induced hypertension, 30 patients with preeclampsia, and 30 patients with severe preeclampsia, respectively, and were divided into pregnancy-induced hypertension group, preeclampsia group, and severe preeclampsia group. Serum levels of reactive oxygen species (ROS), superoxide dismutase (SOD), heme oxygenase-1 (HO-1), glutathione peroxidase (GSH-PX), malondialdehyde (MDA), and uterine artery hemodynamic parameters were compared between the two groups in early pregnancy (8 weeks to 13 weeks plus 6 days). The receiver operating characteristic (ROC) curve was used to evaluate the predictive efficiency of relevant indicators for HDP.
Results The serum levels of SOD and GSH-PX were lower in the case group than that in the control group, and the serum level of MDA and the uterine artery pulsatility index (PI) were higher in the case group than that in the control group (P < 0.05). The serum levels of SOD and GSH-PX gradually decreased, and the serum levels of MDA and PI gradually increased in the pregnancy-induced hypertension group, the preeclampsia group, and the severe preeclampsia group (P < 0.05). The ROC curve showed that the combination of SOD, GSH-PX, MDA, and PI in early pregnancy had a higher predictive efficiency for HDP, with an area under the curve of 0.824, a sensitivity of 81.1%, and a specificity of 76.7%.
Conclusion Patients with HDP have changes in oxidative stress indicators and uterine artery hemodynamic parameters in early pregnancy, and there are differences among patients with different disease severities. The combined detection of SOD, GSH-PX, MDA, and PI in early pregnancy can help predict HDP.
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