Correlation between moderate to severe bronchopulmonary dysplasia and early breastfeeding in preterm infants with a gestational age of ≤32 weeks

LI Jinyang; SHI Qinchuan; HU Xiaoshan; LIU Beibei

doi:10.7619/jcmp.20233629

Journal of Clinical Medicine in Practice > 2024 > 28(6): 79-82, 93. > DOI: 10.7619/jcmp.20233629

LI Jinyang, SHI Qinchuan, HU Xiaoshan, LIU Beibei. Correlation between moderate to severe bronchopulmonary dysplasia and early breastfeeding in preterm infants with a gestational age of ≤32 weeks[J]. Journal of Clinical Medicine in Practice, 2024, 28(6): 79-82, 93. DOI: 10.7619/jcmp.20233629

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Correlation between moderate to severe bronchopulmonary dysplasia and early breastfeeding in preterm infants with a gestational age of ≤32 weeks

Neonatal Intensive Care Unit, Obstetrics and Gynecology Hospital Affiliatedto Nanjing Medical University, Nanjing, Jiangsu, 210004

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Received Date: November 12, 2023
Revised Date: January 03, 2024
Available Online: April 01, 2024

Graphical Abstract

Abstract

Abstract

Objective
To explore the correlation between moderate to severe bronchopulmonary dysplasia (BPD) and early breastfeeding in preterm infants with a gestational age of ≤32 weeks.
Methods
A retrospective analysis was conducted on the clinical data of 220 preterm infants with a gestational age of ≤32 weeks. The preterm infants were dividedinto moderate to severe BPD group (37 cases) and control group (183 cases) based on whether moderate to severe BPD occurred or not. The clinical characteristics, breastfeeding volume, and mother's own milk (MOM) feeding rate were compared between the two groups, and the relationship between breastfeeding and the occurrence of moderate to severe BPD in preterm infants was analyzed.
Results
Univariate analysis showed that the moderate to severe BPD group had a higher proportion of infants with birth weight < 1 500 g, gestational age < 28 weeks, vaginal delivery, Apgar score ≤ 7 at 1 minute after birth, and mechanical ventilation time ≥ 7 days compared to the control group(P < 0.05). The duration of intravenous nutrition was longer in the moderate to severe BPD group (P < 0.05). The moderate to severe BPD group had lower breast milk intake from 0 to 7 days after birth, MOM intake, MOM feeding rate, and breast milk intake from 8 to 14 days after birth compared to the control group (P < 0.05). Multivariate Logistic regression analysis showed that a high volume of breastfeeding from 0 to 7 days after birth was an independent protective factor for the occurrence of moderate to severe BPD in preterm infants (OR=0.865, 95%CI, 0.767 to 0.976, P < 0.05). Gestational age < 28 weeks (OR=5.238, 95%CI, 1.158 to 23.686, P < 0.05), and mechanical ventilation time ≥7 days (OR=22.386, 95%CI, 6.769 to 74.030, P < 0.05) were independent risk factors for the occurrence of moderate to severe BPD in preterm infants.
Conclusion
Early breastfeeding after birth can significantly reduce the risk of moderate to severe BPD in preterm infants with a gestational age of ≤32 weeks, and clinical measures should be actively implemented to promote early breastfeeding.
- preterm infants,
- bronchopulmonary dysplasia,
- breastfeeding,
- mother's own milk feeding,
- mechanical ventilation

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References

[1]	JOBE A H. Mechanisms of lung injury and bronchopulmonary dysplasia[J]. Am J Perinatol, 2016, 33(11): 1076-1078. doi: 10.1055/s-0036-1586107
[2]	BAUD O, MAURY L, LEBAIL F, et al. Effect of early low-dose hydrocortisone on survival without bronchopulmonary dysplasia in extremely preterm infants (PREMILOC): a double-blind, placebo-controlled, multicentre, randomised trial[J]. Lancet, 2016, 387(10030): 1827-1836. doi: 10.1016/S0140-6736(16)00202-6
[3]	ISAYAMA T, LEE S K, MORI R, et al. Comparison of mortality and morbidity of very low birth weight infants between Canada and Japan[J]. Pediatrics, 2012, 130(4): e957-e965. doi: 10.1542/peds.2012-0336
[4]	LODHA A, SESHIA M, MCMILLAN D D, et al. Association of early caffeine administration and neonatal outcomes in very preterm neonates[J]. JAMA Pediatr, 2015, 169(1): 33-38. doi: 10.1001/jamapediatrics.2014.2223
[5]	LAUGHON M M. Vitamin A shortage and risk of bronchopulmonary dysplasia[J]. JAMA Pediatr, 2014, 168(11): 995-996. doi: 10.1001/jamapediatrics.2014.1416
[6]	PRINCIPI N, DI PIETRO G M, ESPOSITO S. Bronchopulmonary dysplasia: clinical aspects and preventive and therapeutic strategies[J]. J Transl Med, 2018, 16(1): 36. doi: 10.1186/s12967-018-1417-7
[7]	VILLAMOR-MARTÍNEZ E, PIERRO M, CAVALLARO G, et al. Mother's own milk and bronchopulmonary dysplasia: a systematic review and meta-analysis[J]. Front Pediatr, 2019, 7: 224. doi: 10.3389/fped.2019.00224
[8]	NATARAJAN G, PAPPAS A, SHANKARAN S, et al. Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia: impact of the physiologic definition[J]. Early Hum Dev, 2012, 88(7): 509-515. doi: 10.1016/j.earlhumdev.2011.12.013
[9]	SHAH P S, LUI K, SJ&#XF; RS G, et al. Neonatal outcomes of very low birth weight and very preterm neonates: an international comparison[J]. J Pediatr, 2016, 177: 144-152. e6. doi: 10.1016/j.jpeds.2016.04.083
[10]	CAO Y, JIANG S Y, SUN J H, et al. Assessment of neonatal intensive care unit practices, morbidity, and mortality among very preterm infants in China[J]. JAMA Netw Open, 2021, 4(8): e2118904. doi: 10.1001/jamanetworkopen.2021.18904
[11]	赵迎春, 张潇月, 朱莹莹, 等. 极低/超低出生体重儿支气管肺发育不良的危险因素分析[J]. 中国优生与遗传杂志, 2022, 30(4): 592-596. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYA202204010.htm
[12]	杨勇晖, 贺晓日, 张雪菲, 等. 极早早产儿支气管肺发育不良的临床特征[J]. 中南大学学报: 医学版, 2023, 48(10): 1592-1601. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYD202310016.htm
[13]	HUANG J L, ZHANG L, TANG J, et al. Human milk as a protective factor for bronchopulmonary dysplasia: a systematic review and meta-analysis[J]. Arch Dis Child Fetal Neonatal Ed, 2019, 104(2): F128-F136. doi: 10.1136/archdischild-2017-314205
[14]	FURMAN L, TAYLOR G, MINICH N, et al. The effect of maternal milk on neonatal morbidity of very low-birth-weight infants[J]. Arch Pediatr Adolesc Med, 2003, 157(1): 66-71. doi: 10.1001/archpedi.157.1.66
[15]	MAAYAN-METZGER A, AVIVI S, SCHUSHAN-EISEN I, et al. Human milk versus formula feeding among preterm infants: short-term outcomes[J]. Am J Perinatol, 2012, 29(2): 121-126. doi: 10.1055/s-0031-1295652
[16]	VILLAMOR-MARTÍNEZ E, PIERRO M, CAVALLARO G, et al. Donor human milk protects against bronchopulmonary dysplasia: a systematic review and meta-analysis[J]. Nutrients, 2018, 10(2): 238. doi: 10.3390/nu10020238
[17]	XU Y, YU Z B, LI Q Q, et al. Dose-dependent effect of human milk on Bronchopulmonary dysplasia in very low birth weight infants[J]. BMC Pediatr, 2020, 20(1): 522. doi: 10.1186/s12887-020-02394-1
[18]	LUND A M, DOMELLÖF M, PIVODIC A, et al. Mother's own milk and its relationship to growth and morbidity in a population-based cohort of extremely preterm infants[J]. J Pediatr Gastroenterol Nutr, 2022, 74(2): 292-300. doi: 10.1097/MPG.0000000000003352
[19]	HALLEUX V D, PIELTAIN C, SENTERRE T, et al. Growth benefits of own mother's milk in preterm infants fed daily individualized fortified human milk[J]. Nutrients, 2019, 11(4): 772. doi: 10.3390/nu11040772
[20]	HAIR A. Own mother's milk significantly decreases the risk of bronchopulmonary dysplasia[J]. Evid Based Nurs, 2018, 21(1): 16. doi: 10.1136/eb-2017-102781

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Correlation between moderate to severe bronchopulmonary dysplasia and early breastfeeding in preterm infants with a gestational age of ≤32 weeks

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