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MA Wei, SHEN Zhengri. Effect of modified Zexie Decoction in treatment of elderly patients with grade 1 of essential hypertension differentiated as syndrome of excessive phlegm and dampness[J]. Journal of Clinical Medicine in Practice, 2024, 28(9): 78-81, 89. DOI: 10.7619/jcmp.20233837
Citation: MA Wei, SHEN Zhengri. Effect of modified Zexie Decoction in treatment of elderly patients with grade 1 of essential hypertension differentiated as syndrome of excessive phlegm and dampness[J]. Journal of Clinical Medicine in Practice, 2024, 28(9): 78-81, 89. DOI: 10.7619/jcmp.20233837
shu

Effect of modified Zexie Decoction in treatment of elderly patients with grade 1 of essential hypertension differentiated as syndrome of excessive phlegm and dampness

  • 1.

    Department of Geriatric Diseases, Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine, Beijing, 101300

  • 2.

    Department of Nephrology, Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine, Beijing, 101300

More Information
  • Received Date: November 28, 2023
  • Revised Date: February 26, 2024
  • Available Online: May 14, 2024
    Graphical Abstract
    • Abstract
  • Objective 

    To observe the clinical efficacy of modified Zexie Decoction in treatment of elderly patients with grade 1 of essential hypertension (extremely high risk) differentiated as syndrome of excessive phlegm and dampness.

    Methods 

    From May 2021 to April 2023, 103 elderly patients with grade 1 of essential hypertension (extremely high risk) in the Department of Geriatric Diseases in the authors' hospital were selected as research objects, and they were randomly divided into control group (n=51) and study group (n=52). The control group received lifestyle interventions, while the study group was treated with modified Zexie Decoction on the basis of the control group. After two weeks of treatment, the clinical efficacy, the score of traditional Chinese medicine symptoms, blood pressure, blood lipid level, and maximum intima-media thickness of the carotid artery (dIMTmax) were compared between the two groups.

    Results 

    The total effective rate in the study group was 90.38 %, which was significantly higher than 56.86 % in the control group (P < 0.05). After treatment, the scores of primary and secondary symptoms in both groups decreased significantly when compared to those before treatment, and the scores of primary and secondary symptoms in the study group were significantly lower than those in the control group (P < 0.05). After treatment, the systolic and diastolic blood pressures in both groups decreased significantly when compared to those before treatment, and the systolic and diastolic blood pressures in the study group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol decreased significantly in both groups, while high-density lipoprotein cholesterol level increased significantly, and the levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol in the study group were significantly lower than those in the control group, but the high-density lipoprotein cholesterol level was significantly higher than that in the control group (P < 0.05). After treatment, the dIMTmax in the treatment group was (0.92±0.12) mm, which was significantly less than (1.10±0.15) mm in the control group (P < 0.05).

    Conclusion 

    Modified Zexie Decoction can effectively improve clinical symptoms in elderly patients with essential hypertension, regulate blood pressure and lipid levels, alleviate vascular endothelial injury, and reduce the carotid intima-media thickness.

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    • References (26)
  • [1]
    徐冬梅, 龚正, 丁兆生. 缬沙坦分别联合氨氯地平与氢氯噻嗪治疗高血压患者的疗效比较[J]. 实用临床医药杂志, 2022, 26(10): 58-61. doi: 10.7619/jcmp.20220186
    [2]
    程雪莲, 金俊, 谈世进. 80岁及以上老年高血压合并衰弱病人的血压变异性研究[J]. 实用老年医学, 2023, 37(5): 509-511. https://www.cnki.com.cn/Article/CJFDTOTAL-SYLA202305018.htm
    [3]
    王增武. 中国高血压流行和防治现状[J]. 中国心血管病研究, 2022, 20(8): 673-678. https://www.cnki.com.cn/Article/CJFDTOTAL-XXGZ202208001.htm
    [4]
    CAI X Q, HUANG H L, SHEN Y H, et al. The influence of abdominal obesity on endothelial function of the tibial artery in the elderly essential hypertensives of different sex[J]. Am J Hypertens, 2021, 34(4): 428.
    [5]
    郑刚. 老年高血压患者从强化降压治疗获益的临床新证据[J]. 中华老年心脑血管病杂志, 2022, 24(6): 662-663. https://www.cnki.com.cn/Article/CJFDTOTAL-LNXG202206028.htm
    [6]
    邱洪, 叶加宝, 殷莺. 沙库巴曲缬沙坦对维持性血液透析合并难治性高血压患者的治疗效果[J]. 实用临床医药杂志, 2022, 26(21): 70-73, 79. doi: 10.7619/jcmp.20221710
    [7]
    《中成药治疗优势病种临床应用指南》标准化项目组. 中成药治疗原发性高血压临床应用指南(2021年)[J]. 中国中西医结合杂志, 2022, 42(7): 773-781. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXJ202207001.htm
    [8]
    童远明, 范建华, 董燕, 等. 经典名方泽泻汤的历史衍变[J]. 中国现代中药, 2023, 25(1): 171-177. https://www.cnki.com.cn/Article/CJFDTOTAL-YJXX202301022.htm
    [9]
    夏坤杰, 向燕, 陈淑琴, 等. 黄芪甲苷Ⅳ预防肥胖性高血压的作用机制研究[J]. 实用临床医药杂志, 2021, 25(19): 66-73. doi: 10.7619/jcmp.20211222
    [10]
    国家心血管病中心国家基本公共卫生服务项目基层高血压管理办公室, 国家基层高血压管理专家委员会. 国家基层高血压防治管理指南2020版[J]. 中国循环杂志, 2021, 36(3): 209-220. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYLY202309001.htm
    [11]
    汤笑尘, 张久亮, 李琳, 等. 高血压病中医病机探析[J]. 中华中医药杂志, 2022, 37(8): 4619-4621. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202208081.htm
    [12]
    代爽, 何庆勇, 杨戈. 中医辨证治疗高血压十法十方[J]. 环球中医药, 2021, 14(2): 316-319. https://www.cnki.com.cn/Article/CJFDTOTAL-HQZY202102034.htm
    [13]
    张晋, 宋昌梅, 杲春阳, 等. 中医传统功法治疗原发性高血压疗效Meta分析[J]. 西部中医药, 2021, 34(5): 79-84. https://www.cnki.com.cn/Article/CJFDTOTAL-GSZY202105021.htm
    [14]
    吴晶, 郎颖, 杜倩倩, 等. 中医"治未病" 对高血压患者健康管理效果的Meta分析[J]. 宁夏医科大学学报, 2022, 44(1): 84-89.
    [15]
    何彦虎, 金华, 张俊鹏, 等. 基于肝脾与肠-肝轴的相关性论高血压病证治[J]. 辽宁中医药大学学报, 2021, 23(6): 130-133. https://www.cnki.com.cn/Article/CJFDTOTAL-LZXB202106028.htm
    [16]
    MAHMUD A, ALAHAIDEB R, ALSHAMMARY H, et al. Ambulatory blood pressure phenotypes, vascular inflammation and arterial stiffness in essential hypertension[J]. J Hypertens, 2021, 39(Supplement 1): e310-e311.
    [17]
    IVANKOVA A, KUZMINOVA N. Metabolic status in patients with essential hypertension and different forms of concomitant extrasystoles[J]. Atherosclerosis, 2021, 331: E229.
    [18]
    冯德光, 黄建玉, 刘泽, 等. 高龄男性原发性高血压患者血压昼夜节律与动脉硬化程度的关系初探[J]. 中华老年心脑血管病杂志, 2021, 23(8): 796-799. https://www.cnki.com.cn/Article/CJFDTOTAL-LNXG202108005.htm
    [19]
    李佳奇, 刘莉, 韩宇博, 等. 加味黄连温胆汤治疗H型高血压痰瘀互结证患者临床疗效及对LVMI的影响[J]. 天津中医药, 2023, 40(1): 14-19. https://www.cnki.com.cn/Article/CJFDTOTAL-TJZY202301004.htm
    [20]
    王亦菲, 郭丽君, 高风, 等. 20种常用中成药治疗高血压病的临床研究证据图分析[J]. 中国中药杂志, 2022, 47(18): 5097-5105. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZY202218029.htm
    [21]
    蔡秀芝, 杨庆有, 赵雪. 加味泽泻汤治疗原发性高血压病痰湿壅盛型患者的疗效观察[J]. 世界中西医结合杂志, 2020, 15(2): 301-305. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZX202002022.htm
    [22]
    姚应水. 半夏白术天麻汤联合泽泻汤治疗高血压的Meta分析[J]. 现代中药研究与实践, 2021, 35(2): 70-74. https://www.cnki.com.cn/Article/CJFDTOTAL-JZZY202102016.htm
    [23]
    韩飞, 苏莹, 苏苑苑, 等. 李平教授治疗高血压眩晕用药规律探析[J]. 世界中西医结合杂志, 2023, 18(3): 449-454. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZX202303005.htm
    [24]
    石桂芳, 李彦芳, 孙秀全, 等. 山菊降压片联合福辛普利治疗老年原发性高血压的临床研究[J]. 现代药物与临床, 2023, 38(2): 340-345. https://www.cnki.com.cn/Article/CJFDTOTAL-GWZW202302013.htm
    [25]
    宿艳敏, 穆海风, 王芳, 等. 养血清脑颗粒联合缬沙坦氢氯噻嗪治疗老年原发性高血压的临床研究[J]. 现代药物与临床, 2022, 37(5): 1018-1022. https://www.cnki.com.cn/Article/CJFDTOTAL-GWZW202205016.htm
    [26]
    唐兆海. 泽泻汤加味治疗老年原发性高血压的疗效观察[J]. 现代诊断与治疗, 2021, 32(22): 3544-3545. https://www.cnki.com.cn/Article/CJFDTOTAL-XDZD202122008.htm
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