Correlations of prognostic nutritional index and modified Glasgow prognostic score with prognosis in patients with cervical cancer

HUANG Xiaoli; HUANG Xiaoyan; SONG Shuhui; ZHANG Ying

doi:10.7619/jcmp.20233927

Journal of Clinical Medicine in Practice > 2024 > 28(20): 12-17. > DOI: 10.7619/jcmp.20233927

HUANG Xiaoli, HUANG Xiaoyan, SONG Shuhui, ZHANG Ying. Correlations of prognostic nutritional index and modified Glasgow prognostic score with prognosis in patients with cervical cancer[J]. Journal of Clinical Medicine in Practice, 2024, 28(20): 12-17. DOI: 10.7619/jcmp.20233927

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Correlations of prognostic nutritional index and modified Glasgow prognostic score with prognosis in patients with cervical cancer

1.
School of Nursing of Jiangxi Medical College, Shangrao, Jiangxi, 334099
2.
Department of Obstetrics and Gynecology, Maternity and Child Health Care Hospital of Shangrao City in Jiangxi Province, Shangrao, Jiangxi, 334099

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Received Date: December 04, 2023
Revised Date: January 26, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the prognostic value of prognostic nutritional index (PNI) and modified Glasgow prognostic score (mGPS) in patients with cervical cancer.
Methods
A total of 120 patients with cervical cancer were selected as the study subjects. Patients' data were collected and analyzed, with follow-up conducted until June 30, 2023. Kaplan-Meier method was used to plot survival curves. Log-rank test and Cox regression analysis were employed to identify prognostic factors.
Results
The median follow-up time for patients in this study was 61 months, with a median survival time of 52 months. During the follow-up period, 41 patients (34.17%) died. The 3-year and 5-year survival rates were 82.50% and 66.67%, respectively. Receiver operating characteristic (ROC) curves showed that the areas under the curve (AUC) for PNI, mGPS, albumin (ALB), lymphocytes (LYM), C-reactive protein (CRP), and neutrophils (NEU) in predicting patient prognosis were 0.90, 0.81, 0.84, 0.86, 0.82, and 0.71, respectively. The optimal cutoff values were determined to be 41.80 for PNI, 0.50 points for mGPS, 34.25 g/L for ALB, 1.44×10⁹/L for LYM, 5.45×10⁹/L for CRP and 7.25 mg/L for NEU. Cox regression analysis indicated that PNI (HR=4.18, 95%CI=2.83 to 9.21, P=0.015), mGPS [HR=1.95, 95%CI=1.37 to 3.59, P < 0.001 (mGPS=1 point); HR=3.07, 95%CI=2.38 to 5.36, P < 0.001(mGPS=2 points)] and International Federation of Gynecology and Obstetrics (FIGO) staging [HR=2.03, 95%CI=1.34 to 3.85, P=0.030(FIGO stage=stage Ⅲ); HR=3.46, 95%CI=2.15 to 6.62, P=0.003 (FIGO stage=stage Ⅳ)]were significant risk factors affecting the prognosis of cervical cancer patients.
Conclusion
PNI, mGPS and FIGO staging are important predictors of prognosis in cervical cancer patients. Attention to PNI and mGPS before treatment may help improve clinical outcomes.
- prognostic nutritional index,
- modified Glasgow prognostic score,
- cervical neoplasms,
- survival time,
- prognosis

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References (29)

References

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