Correlations of preoperative serum V-set and immunoglobulin domain 4 and long chain non-coding ribonucleic acid SBF2-antisense RNA1 with acute kidney injury after percutaneous nephrolithotomy in patients with renal calculus

YAO Junbo; JIA Bo; LIU Jiayuan; ZOU Yiming; DENG Siwen

doi:10.7619/jcmp.20234050

Journal of Clinical Medicine in Practice > 2024 > 28(10): 29-34. > DOI: 10.7619/jcmp.20234050

YAO Junbo, JIA Bo, LIU Jiayuan, ZOU Yiming, DENG Siwen. Correlations of preoperative serum V-set and immunoglobulin domain 4 and long chain non-coding ribonucleic acid SBF2-antisense RNA1 with acute kidney injury after percutaneous nephrolithotomy in patients with renal calculus[J]. Journal of Clinical Medicine in Practice, 2024, 28(10): 29-34. DOI: 10.7619/jcmp.20234050

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Correlations of preoperative serum V-set and immunoglobulin domain 4 and long chain non-coding ribonucleic acid SBF2-antisense RNA1 with acute kidney injury after percutaneous nephrolithotomy in patients with renal calculus

Department of Urinary Surgery, Dongxihu District People's Hospital of Wuhan City of Hubei Province, Wuhan, Hubei, 430040

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Received Date: December 12, 2023
Revised Date: February 26, 2024
Available Online: May 31, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the relationships of preoperative serum V-set and immunoglobulin domain 4 (VSIG4) and long chain non-coding ribonucleic acid (LncRNA) SBF2 antisense RNA1 (SBF2-AS1) with acute kidneyinjury (AKI) after percutaneous nephrolithotomy in patients with renal calculus.
Methods
A total of 109 patients with renal calculus in the hospital from January 2020 to December 2022 were selected as research objects. Serum VSIG4 level and LncRNA SBF2-AS1 expression were detected in all the patients before operation, and incidence of AKI was recorded after operation. Multiple Logistic regression model was used to analyze the factors affecting AKI after percutaneous nephrolithotomy in patients with renal calculus; the receiver operating characteristic (ROC) curve was used to analyze the values of VSIG4 and LncRNA SBF2-AS1 in predicting AKI after percutaneous nephrolithotomy in patients with renal calculus.
Results
In this study, 16 cases had AKI after operation. The serum VSIG4 level in the AKI group was significantly lower than that in the non-AKI group, while the LncRNA SBF2-AS1 expression was significantly higher than that in the non-AKI group (P < 0.05). Multivariate Logistic regression analysis showed that preoperative high level of uric acid, preoperative high expression of LncRNA SBF2-AS1, the longer operation time and intraoperative hypotension were the risk factors for AKI after percutaneous nephrolithotomy in patients with renal calculus (P < 0.05), while preoperative high level of VSIG4 was the protective factor (P < 0.05). The values of area under the curve of preoperative serum VSIG4 and LncRNA SBF2-AS1 in predicting AKI after percutaneous nephrolithotomy in patients with renal calculus were 0.854 and 0.705 respectively, and the area under the curve of combined prediction of the two indexes was 0.948, which was significantly higher than that of single index prediction (Z=1.995, 2.958, P < 0.05).
Conclusion
Decreased preoperative serum VSIG4 level and increased expression of LncRNA SBF2-AS1 in patients with renal calculus are associated with the occurrence of AKI after percutaneous nephrolithotomy, and the combined detection of preoperative VSIG4 and LncRNA SBF2-AS1 can predict the risk of AKI after operation.

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References

[1]	SIENER R. Nutrition and kidney stone disease[J]. Nutrients, 2021, 13(6): 1917. doi: 10.3390/nu13061917
[2]	王培龙, 李笑然, 何藄琪, 等. 单通道经皮肾镜取石术联合输尿管软镜与输尿管软镜钬激光碎石术治疗复杂性肾结石的效果比较[J]. 实用临床医药杂志, 2023, 9(2): 101-104, 112. doi: 10.7619/jcmp.20221893
[3]	PILLAI S, KRIPLANI A, CHAWLA A, et al. Acute kidney injury post-percutaneous nephrolithotomy (PNL): prospective outcomes from a university teaching hospital[J]. J Clin Med, 2021, 10(7): 1373. doi: 10.3390/jcm10071373
[4]	卢莹莹, 叶雨辰, 王妍, 等. 巨噬细胞在肾脏损伤及修复中的作用和机制研究进展[J]. 现代生物医学进展, 2018, 18(23): 4583-4586. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX201823042.htm
[5]	HUANG X Y, FENG Z Q, JIANG Y Z, et al. VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages[J]. Sci Adv, 2019, 5(1): eaau7426. doi: 10.1126/sciadv.aau7426
[6]	LIU J, LAO L Y, CHEN J N, et al. The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer[J]. Nat Cancer, 2021, 2(4): 457-473. doi: 10.1038/s43018-021-00196-7
[7]	RIEGE K, HÖLZER M, KLASSERT T E, et al. Massive effect on LncRNAs in human monocytes during fungal and bacterial infections and in response to vitamins A and D[J]. Sci Rep, 2017, 7: 40598. doi: 10.1038/srep40598
[8]	KELLUM J A, LAMEIRE N, ASPELIN P, et al. Kidney disease: Improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury[J]. Kidney Int Suppl, 2012, 2(1): 1-138. doi: 10.1038/kisup.2012.1
[9]	FULLA J, PRASANCHAIMONTRI P, WRIGHT H C, et al. Acute kidney injury and percutaneous nephrolithotomy: incidence and predictive factors[J]. World J Urol, 2022, 40(2): 563-567. doi: 10.1007/s00345-021-03874-4
[10]	YU J, PARK H K, KWON H J, et al. Risk factors for acute kidney injury after percutaneous nephrolithotomy: Implications of intraoperative hypotension[J]. Medicine, 2018, 97(30): e11580. doi: 10.1097/MD.0000000000011580
[11]	BONAVIA A, SINGBARTL K. A review of the role of immune cells in acute kidney injury[J]. Pediatr Nephrol, 2018, 33(10): 1629-1639. doi: 10.1007/s00467-017-3774-5
[12]	CAO Q, HARRIS D C H, WANG Y P. Macrophages in kidney injury, inflammation, and fibrosis[J]. Physiology (Bethesda), 2015, 30(3): 183-194.
[13]	LI J L, DIAO B, GUO S, et al. VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism[J]. Nat Commun, 2017, 8(1): 1322. doi: 10.1038/s41467-017-01327-4
[14]	LIU B, CHENG L, GAO H H, et al. The biology of VSIG4: Implications for the treatment of immune-mediated inflammatory diseases and cancer[J]. Cancer Lett, 2023, 553: 215996. doi: 10.1016/j.canlet.2022.215996
[15]	ZHANG D Z, SHEN X, PANG K, et al. VSIG4 alleviates intracerebral hemorrhage induced brain injury by suppressing TLR4-regulated inflammatory response[J]. Brain Res Bull, 2021, 176: 67-75. doi: 10.1016/j.brainresbull.2021.08.008
[16]	WANG Y N, DING J, SONG H J, et al. VSIG4 regulates macrophages polarization and alleviates inflammation through activating PI3K/AKT and inhibiting TLR4/NF-κB pathway in myocardial ischemia-reperfusion injury rats[J]. Physiol Int, 2022: 5.
[17]	LI Y, LIU Y, LI F R, et al. VSIG4 overexpression alleviates acute kidney injury of mice via inhibition of M1-macrophages activation[J]. Ann Transl Med, 2022, 10(10): 559. doi: 10.21037/atm-22-1621
[18]	ZHANG J, LI K Y, LIU X Y, et al. Up-regulation of VSIG4 alleviates kidney transplantation-associated acute kidney injury through suppressing inflammation and ROS via regulation of AKT signaling[J]. Free Radic Biol Med, 2021: S0891-S5849(21)00843-1.
[19]	TAN F S, CHEN J L, WANG B, et al. LncRNA SBF2-AS1: a budding star in various cancers[J]. Curr Pharm Des, 2022, 28(18): 1513-1522. doi: 10.2174/1381612828666220418131506
[20]	FU D W, LIU A C. LncRNA SBF2-AS1 promotes diffuse large B-cell lymphoma growth by regulating FGFR2 via sponging miR-494-3p[J]. Cancer Manag Res, 2021, 13: 571-578. doi: 10.2147/CMAR.S284258
[21]	YANG X Q, ZHANG Y Y, FAN H Y. Downregulation of SBF2-AS1 functions as a tumor suppressor in clear cell renal cell carcinoma by inhibiting miR-338-3p-targeted ETS1[J]. Cancer Gene Ther, 2021, 28(7/8): 813-827.
[22]	TAWFICK A, MATBOLI M, SHAMLOUL S, et al. Predictive urinary RNA biomarkers of kidney injury after extracorporeal shock wave lithotripsy[J]. World J Urol, 2022, 40(6): 1561-1567. doi: 10.1007/s00345-022-03996-3
[23]	EJAZ A A, NAKAGAWA T, KANBAY M, et al. Hyperuricemia in kidney disease: a major risk factor for cardiovascular events, vascular calcification, and renal damage[J]. Semin Nephrol, 2020, 40(6): 574-585. doi: 10.1016/j.semnephrol.2020.12.004
[24]	MATHIS M R, NAIK B I, FREUNDLICH R E, et al. Preoperative risk and the association between hypotension and postoperative acute kidney injury[J]. Anesthesiology, 2020, 132(3): 461-475.

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Correlations of preoperative serum V-set and immunoglobulin domain 4 and long chain non-coding ribonucleic acid SBF2-antisense RNA1 with acute kidney injury after percutaneous nephrolithotomy in patients with renal calculus