Correlations between soluble growth stimulation expressed gene 2 protein, myoglobin, interleukin-6 levels and cardiac function in elderly patients with diastolic heart failure complicated with sarcopenia

ZHU Qi; JI Meili; ZHUANG Shihong

doi:10.7619/jcmp.20234138

Journal of Clinical Medicine in Practice > 2024 > 28(9): 57-61. > DOI: 10.7619/jcmp.20234138

ZHU Qi, JI Meili, ZHUANG Shihong. Correlations between soluble growth stimulation expressed gene 2 protein, myoglobin, interleukin-6 levels and cardiac function in elderly patients with diastolic heart failure complicated with sarcopenia[J]. Journal of Clinical Medicine in Practice, 2024, 28(9): 57-61. DOI: 10.7619/jcmp.20234138

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Correlations between soluble growth stimulation expressed gene 2 protein, myoglobin, interleukin-6 levels and cardiac function in elderly patients with diastolic heart failure complicated with sarcopenia

Department of Geriatric Medicine, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing First Hospital, Nanjing, Jiangsu, 210008

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Received Date: December 19, 2023
Revised Date: March 28, 2024
Available Online: May 14, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the relationship between the levels of soluble growth stimulation expressed gene 2 protein (sST2), myoglobin (Myo), interleukin-6 (IL-6) in peripheral blood and cardiac function in elderly patients with diastolic heart failure (DHF) complicated with sarcopenia.
Methods
A total of 122 patients with DHF were divided into DHF complicated with sarcopenia group (60 cases) and DHF group (62 cases) according to the presence or absence of sarcopenia. In addition, 58 healthy healthy population with physical examination and 60 patients with sarcopenia alone were included in the control group and sarcopenia alone group, respectively. The levels of sST2, Myo, IL-6 and cardiac function indexes[left ventricular ejection fraction (LVEF), cardiac output (CO), heart rate (HR), stroke volume (SV), and cardiac index (CI)]were measured in each group. Pearson correlation analysis was used to analyze the correlations between sST2, Myo, IL-6 and each cardiac function index. Receiver operating characteristic (ROC) curves were drawn to analyze the diagnostic efficacy of sST2, Myo, IL-6 alone and their combination in diagnosing DHF complicated with sarcopenia.
Results
Compared with the control groupand the sarcopenia alone group, the levels of sST2, Myo, IL-6 and HR were increased, while LVEF, CO, SV, and CI were decreased in the DHF group and the DHF complicated with sarcopenia group (P < 0.05). Compared with the DHF group, the levels of sST2, Myo, IL-6 and HR were increased, while LVEF, CO, SV, and CI were decreased in the DHF complicated with sarcopenia group (P < 0.05). The sST2, Myo, and IL-6 were negatively correlated with LVEF, CO, SV, and CI (P < 0.001), and positively correlated with HR (P < 0.001). The sST2, Myo, IL-6, LVEF, and SV were independent influencing factors for DHF complicated with sarcopenia (P < 0.05). The area under the curve of combined detection of sST2, Myo, and IL-6 for diagnosing DHF complicated with sarcopenia was 0.936, indicating a better diagnostic efficacy than individual tests.
Conclusion
The levels of sST2, Myo, and IL-6 in peripheral blood are significantly increased in elderly patients with DHF complicated with sarcopenia, and these markers are significantly correlated with cardiac function indexes. Combined detection of these three markers has a higher diagnostic efficacy for DHF complicated with sarcopenia.
- soluble growth stimulation expressed gene 2 protein,
- myoglobin,
- interleukin-6,
- diastolic heart failure,
- sarcopenia,
- cardiac function

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References (19)

References

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Correlations between soluble growth stimulation expressed gene 2 protein, myoglobin, interleukin-6 levels and cardiac function in elderly patients with diastolic heart failure complicated with sarcopenia