Effective dose and safety of ciprofol in combination with butorphanol for painless gastroscopy in elderly patients

FANG Zhiyong; QIU Xiaojuan; FENG Tao; BIAN Qingming

doi:10.7619/jcmp.20234289

Journal of Clinical Medicine in Practice > 2024 > 28(12): 82-85. > DOI: 10.7619/jcmp.20234289

FANG Zhiyong, QIU Xiaojuan, FENG Tao, BIAN Qingming. Effective dose and safety of ciprofol in combination with butorphanol for painless gastroscopy in elderly patients[J]. Journal of Clinical Medicine in Practice, 2024, 28(12): 82-85. DOI: 10.7619/jcmp.20234289

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Effective dose and safety of ciprofol in combination with butorphanol for painless gastroscopy in elderly patients

1.
Department of Anesthesiology, Lishui District People's Hospital of Nanjing City, Nanjing, Jiangsu, 211200
2.
Department of Anesthesiology, Jiangsu Cancer Hospital, Nanjing, Jiangsu, 210009

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Received Date: December 28, 2023
Revised Date: March 20, 2024
Available Online: June 28, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the median effective dose (ED₅₀) and 95% effective dose (ED₉₅) of ciprofol in combination with butorphanol for painless gastroscopy in elderly patients.
Methods
A total of 27 elderly patients with selective gastroscopy were conducted with intravenous induction of 5 μg/kg butorphanol for at least 30 seconds, and 3 minutes later, they were administered intravenously with ciprofol for at least 30 seconds; gastroscopy was performed when the eyelash reflex disappeared or the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) score was less than one point. The initial dose of ciprofol was set as 0.2 mg/kg, and the modified sequential allocation method was used; if there was a positive response during the insertion of the gastroscope, the dose for the next patient would increase by one level, and vice versa, the dose would decrease by one level, with an adjacent dose concentration gradient of 0.05 mg/kg. A positive response to gastroscope insertion was defined as coughing, swallowing, or limb movements when the gastroscope entered the throat. The study was terminated after 7 reversals in ciprofol dose adjustments. ED₅₀, ED₉₅, and corresponding 95% confidence intervals (95%CI) of ciprofol combined with butorphanol for painless gastroscopy were calculated.
Results
When combined with butorphanol, the ED₅₀ of ciprofol for painless gastroscopy in elderly patients was 0.253 mg/kg (95%CI, 0.219 to 0.290), and the ED₉₅ was 0.328 mg/kg (95%CI, 0.290 to 0.521).
Conclusion
When combined with butorphanol, the ED₅₀ of ciprofol for painless gastroscopy in elderly patients is 0.253 mg/kg, and the ED₉₅ is 0.328 mg/kg.
- ciprofol,
- butorphanol,
- elderly patients,
- gastroscopy,
- effective dose,
- sedation

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References (16)

References

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Effective dose and safety of ciprofol in combination with butorphanol for painless gastroscopy in elderly patients

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