Prevalence of frailty in patients with rheumatoid arthritis: a systematic review

XU Renju; CHEN Yan; CHEN Yujie; ZHU Yuxuan; JIN Ziyi; SUN Yue; ZHU Manli

doi:10.7619/jcmp.20240618

Journal of Clinical Medicine in Practice > 2024 > 28(11): 45-52. > DOI: 10.7619/jcmp.20240618

XU Renju, CHEN Yan, CHEN Yujie, ZHU Yuxuan, JIN Ziyi, SUN Yue, ZHU Manli. Prevalence of frailty in patients with rheumatoid arthritis: a systematic review[J]. Journal of Clinical Medicine in Practice, 2024, 28(11): 45-52. DOI: 10.7619/jcmp.20240618

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Prevalence of frailty in patients with rheumatoid arthritis: a systematic review

1.
Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, Jiangsu, 210008
2.
Department of Nursing, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, 210008
3.
Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, 210008

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Received Date: February 05, 2024
Revised Date: March 26, 2024
Available Online: June 17, 2024

Graphical Abstract

Abstract

Abstract

Objective
To systematically evaluate the prevalence of frailty in patients with rheumatoid arthritis (RA).
Methods
A systematic search method for observational studies on the prevalence of frailty in patients with RA was conducted, and literature screening, data extraction as well as evaluation of literature quality were performed in strict accordance with evidence-based medical research methodology. Meta-analysis and Egger's linear regression analysis were performed by Stata 16.0 software.
Results
Twenty-six literatures were included in the study, including a total sample size of 22, 547 patients. The results of the analysis showed that the total prevalence of frailty in patients with RA was 36% (95%CI, 0.26 to 0.45, P < 0.001), and the prevalence of pre-frailty was 43% (95%CI, 0.36 to 0.50, P < 0.001). The results of subgroup analysis showed that the incidence of frailty was higher in RA patients with features of female, age over 60 years old, hospitalization, living in European region and evaluation with multi-dimensional comprehensive frailty assessment tool and the specific RA frailty assessment tool.
Conclusion
The overall incidence of frailty and pre-frailty in RA patients is high, and there are differences in the incidence of frailty among patients with different ages, genders, environments, regions, and types of assessment tools.
- rheumatoid arthritis,
- frailty,
- systematic review,
- evidence based medicine

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References (43)

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Prevalence of frailty in patients with rheumatoid arthritis: a systematic review