Prevalence of frailty in patients with rheumatoid arthritis: a systematic review

XU Renju; CHEN Yan; CHEN Yujie; ZHU Yuxuan; JIN Ziyi; SUN Yue; ZHU Manli

doi:10.7619/jcmp.20240618

Journal of Clinical Medicine in Practice > 2024 > 28(11): 45-52. > DOI: 10.7619/jcmp.20240618

XU Renju, CHEN Yan, CHEN Yujie, ZHU Yuxuan, JIN Ziyi, SUN Yue, ZHU Manli. Prevalence of frailty in patients with rheumatoid arthritis: a systematic review[J]. Journal of Clinical Medicine in Practice, 2024, 28(11): 45-52. DOI: 10.7619/jcmp.20240618

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Prevalence of frailty in patients with rheumatoid arthritis: a systematic review

1.
Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, Jiangsu, 210008
2.
Department of Nursing, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, 210008
3.
Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, 210008

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Received Date: February 05, 2024
Revised Date: March 26, 2024
Available Online: June 17, 2024

Graphical Abstract

Abstract

Abstract

Objective
To systematically evaluate the prevalence of frailty in patients with rheumatoid arthritis (RA).
Methods
A systematic search method for observational studies on the prevalence of frailty in patients with RA was conducted, and literature screening, data extraction as well as evaluation of literature quality were performed in strict accordance with evidence-based medical research methodology. Meta-analysis and Egger's linear regression analysis were performed by Stata 16.0 software.
Results
Twenty-six literatures were included in the study, including a total sample size of 22, 547 patients. The results of the analysis showed that the total prevalence of frailty in patients with RA was 36% (95%CI, 0.26 to 0.45, P < 0.001), and the prevalence of pre-frailty was 43% (95%CI, 0.36 to 0.50, P < 0.001). The results of subgroup analysis showed that the incidence of frailty was higher in RA patients with features of female, age over 60 years old, hospitalization, living in European region and evaluation with multi-dimensional comprehensive frailty assessment tool and the specific RA frailty assessment tool.
Conclusion
The overall incidence of frailty and pre-frailty in RA patients is high, and there are differences in the incidence of frailty among patients with different ages, genders, environments, regions, and types of assessment tools.
- rheumatoid arthritis,
- frailty,
- systematic review,
- evidence based medicine

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References (43)

References

[1]	耿研, 谢希, 王昱, 等. 类风湿关节炎诊疗规范[J]. 中华内科杂志, 2022, 61(1): 51-59. doi: 10.3760/cma.j.cn112138-20210616-00426
[2]	ALMUTAIRI K, NOSSENT J, PREEN D, et al. The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review[J]. Rheumatol Int, 2021, 41(5): 863-877. doi: 10.1007/s00296-020-04731-0
[3]	田新平, 李梦涛, 曾小峰. 我国类风湿关节炎诊治现状与挑战: 来自中国类风湿关节炎2019年年度报告[J]. 中华内科杂志, 2021, 60(7): 593-598. doi: 10.3760/cma.j.cn112138-20210207-00113
[4]	DENT E, MORLEY J E, CRUZ-JENTOFT A J, et al. Physical frailty: ICFSR international clinical practice guidelines for identification and management[J]. J Nutr Health Aging, 2019, 23(9): 771-787. doi: 10.1007/s12603-019-1273-z
[5]	SALAFFI F, ANGELIS R D, FARAH S, et al. Frailty as a novel predictor of achieving comprehensive disease control (CDC) in rheumatoid arthritis[J]. Clin Rheumatol, 2021, 40(12): 4869-4877. doi: 10.1007/s10067-021-05744-1
[6]	HANLON P, MORTON F, SIEBERT S, et al. Frailty in rheumatoidrmdopen-2021-002111 arthritis and its relationship with disease activity, hospitalisation and mortality: a longitudinal analysis of the Scottish Early Rheumatoid Arthritis cohort and UK Biobank[J]. RMD Open, 2022, 8(1): e002111. doi: 10.1136/rmdopen-2021-002111
[7]	ANDREWS J S, TRUPIN L, YELIN E H, et al. Frailty and reduced physical function go hand in hand in adults with rheumatoid arthritis: a US observational cohort study[J]. Clin Rheumatol, 2017, 36(5): 1031-1039. doi: 10.1007/s10067-017-3541-9
[8]	KOJIMA M, KOJIMA T, WAGURI-NAGAYA Y, et al. Depression, physical function, and disease activity associated with frailty in patients with rheumatoid arthritis[J]. Mod Rheumatol, 2021, 31(5): 979-986. doi: 10.1080/14397595.2020.1838402
[9]	LI G W, CHEN M S, LI X Y, et al. Frailty and risk of osteoporotic fractures in patients with rheumatoid arthritis: Data from the Ontario Best Practices Research Initiative[J]. Bone, 2019, 127: 129-134. doi: 10.1016/j.bone.2019.06.006
[10]	ANDREWS J S, TRUPIN L, WYSHAM K D, et al. The impact of frailty on changes in physical function and disease activity among adults with rheumatoid arthritis[J]. ACR Open Rheumatol, 2019, 1(6): 366-372. doi: 10.1002/acr2.11051
[11]	胡雁, 郝玉芳. 循证护理学[M]. 2版. 北京: 人民卫生出版社, 2018: 1-32.
[12]	曾宪涛, 任学群. 应用STATA做Meta分析[M]. 2版. 北京: 中国协和医科大学出版社, 2017: 71-73.
[13]	YOSHII I, KONDO M. Clinical characteristics of frailty in Japanese rheumatoid arthritis patients[J]. J Frailty Aging, 2020, 9(3): 158-164.
[14]	WYSHAM K D, SHOBACK D M, ANDREWS J S, et al. Sex differences in frailty and its association with low bone mineral density in rheumatoid arthritis[J]. Bone Rep, 2020, 12: 100284. doi: 10.1016/j.bonr.2020.100284
[15]	TADA M, YAMADA Y, MANDAI K, et al. Correlation between frailty and disease activity in patients with rheumatoid arthritis: Data from the CHIKARA study[J]. Geriatr Gerontol Int, 2019, 19(12): 1220-1225. doi: 10.1111/ggi.13795
[16]	SALAFFI F, CARLO M D, FARAH S, et al. Prevalence of frailty and its associated factors in patients with rheumatoid arthritis: a cross-sectional analysis[J]. Clin Rheumatol, 2019, 38(7): 1823-1830. doi: 10.1007/s10067-019-04486-5
[17]	SALAFFI F, CARLO M D, FARAH S, et al. The Comprehensive Rheumatologic Assessment of Frailty (CRAF): development and validation of a multidimensional frailty screening tool in patients with rheumatoid arthritis[J]. Clin Exp Rheumatol, 2020, 38(3): 488-499.
[18]	OZEKI S, TAKEUCHI K, YASUOKA M, et al. Comparison of frailty associated factors between older adult patients with rheumatoid arthritis and community dwellers[J]. Arch Gerontol Geriatr, 2021, 96: 104455. doi: 10.1016/j.archger.2021.104455
[19]	OETSMA S, BOONEN A, STARMANS M, et al. Validation of two frailty questionnaires in older patients with rheumatoid arthritis: a cross-sectional study[J]. Clin Exp Rheumatol, 2020, 38(3): 523-528.
[20]	MINAMINO H, KATSUSHIMA M, TORⅡ M, et al. Habitual fish intake negatively correlates with prevalence of frailty among patients with rheumatoid arthritis[J]. Sci Rep, 2021, 11(1): 5104. doi: 10.1038/s41598-021-84479-0
[21]	HAIDER S, GRABOVAC I, BERNER C, et al. Frailty in seropositive rheumatoid arthritis patients of working age: a cross-sectional study[J]. Clin Exp Rheumatol, 2019, 37(4): 585-592.
[22]	COOK M J, VERSTAPPEN S M M, LUNT M, et al. Increased frailty in individuals with osteoarthritis and rheumatoid arthritis and the influence of comorbidity: an analysis of the UK biobank cohort[J]. Arthritis Care Res, 2022, 74(12): 1989-1996. doi: 10.1002/acr.24747
[23]	CLEUTJENS F, VAN MOERBEKE A, BOONEN A, et al. Frailty in relation to psycho-social factors in elderly patients with rheumatoid arthritis: a cross-sectional mixed qualitative-quantitative study[J]. Int J Rheum Dis, 2021, 24(6): 766-773. doi: 10.1111/1756-185X.14110
[24]	BARILE-FABRIS L A, PÉREZ-CRISTOBAL M, MERLOS-LÓPEZ R J, et al. Frailty syndrome in patients with rheumatoid arthritis[J]. Rev Med Inst Mex Seguro Soc, 2016, 54(Suppl 2): S210-S215.
[25]	BAK E, MŁYNARSKA A, MARCISZ C, et al. Factors that affect the assessment of the quality of life of rheumatoid arthritis patients depending on the prevalence of frailty syndrome[J]. Health Qual Life Outcomes, 2020, 18(1): 216. doi: 10.1186/s12955-020-01472-3
[26]	龚丽, 门雪妍, 曹冰莹. 老年类风湿关节炎病人衰弱现状及影响因素[J]. 护理研究, 2020, 34(19): 3506-3508. doi: 10.12102/j.issn.1009-6493.2020.19.029
[27]	SUZUKI M, ASAI, SOBUE Y, et al. Influence of frailty on patient global assessment in rheumatoid arthritis[J]. Geriatr Gerontol Int, 2022, 22(5): 399-404. doi: 10.1111/ggi.14375
[28]	SOBUE Y, SUZUKI M, OHASHI Y, et al. Relationship between locomotive syndrome and frailty in rheumatoid arthritis patients by locomotive syndrome stage[J]. Mod Rheumatol, 2022, 32(3): 546-553. doi: 10.1093/mr/roab024
[29]	TANSKI W, WÓJCIGA J, JANKOWSKA-POLANSKA B. Association between malnutrition and quality of life in elderly patients with rheumatoid arthritis[J]. Nutrients, 2021, 13(4): 1259. doi: 10.3390/nu13041259
[30]	OHASHI Y, TAKAHASHI N, SOBUE Y, et al. Factors associated with frailty in rheumatoid arthritis patients with decreased renal function[J]. Mod Rheumatol, 2023, 33(2): 323-329. doi: 10.1093/mr/roac018
[31]	MATSUMOTO Y, TADA M, YAMADA Y, et al. The bioimpedance phase angle may be associated with frailty in rheumatoid arthritis patients: Results from a prospective, cohort study[J]. Mod Rheumatol, 2023, 33(4): 732-738. doi: 10.1093/mr/roac078
[32]	FURUYA T, OH K, IKARI K, et al. Factors associated with frailty in Japanese patients with rheumatoid arthritis: results from the Institute of Rheumatology Rheumatoid Arthritis cohort study[J]. Clin Rheumatol, 2022, 41(2): 405-410. doi: 10.1007/s10067-021-05938-7
[33]	SOBUE Y, SUZUKI M, OHASHI Y, et al. Validation of grip strength as a measure of frailty in rheumatoid arthritis[J]. Sci Rep, 2022, 12(1): 21090. doi: 10.1038/s41598-022-21533-5
[34]	SOBUE Y, SUZUKI M, OHASHI Y, et al. Relationship between frailty and methotrexate discontinuation due to adverse events in rheumatoid arthritis patients[J]. Clin Rheumatol, 2023, 42(8): 2069-2077. doi: 10.1007/s10067-023-06639-z
[35]	LIEBER S B, NAVARRO-MILLÁN I, RAJAN M, et al. Prevalence of frailty in ankylosing spondylitis, psoriatic arthritis, and rheumatoid arthritis: data from a national claims dataset[J]. ACR Open Rheumatol, 2022, 4(4): 300-305. doi: 10.1002/acr2.11388
[36]	高倩倩, 梅凡, 赵黎, 等. 老年糖尿病患者衰弱发生率的系统评价[J]. 中华护理杂志, 2021, 56(5): 686-693. doi: 10.3761/j.issn.0254-1769.2021.05.007
[37]	FRIED L P, FERRUCCI L, DARER J, et al. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care[J]. J Gerontol A Biol Sci Med Sci, 2004, 59(3): 255-263. doi: 10.1093/gerona/59.3.M255
[38]	王婷婷, 马慧珍, 邓小岚, 等. 血常规中炎症指标与衰弱及衰弱前期的关系[J]. 实用临床医药杂志, 2022, 26(19): 87-91. doi: 10.7619/jcmp.20221443
[39]	SALAFFI F, MATTEO A D, FARAH S, et al. Inflammaging and frailty in immune-mediated rheumatic diseases: how to address and score the issue[J]. Clin Rev Allergy Immunol, 2023, 64(2): 206-221.
[40]	袁红丽, 王娴, 汪秀梅, 等. 类风湿关节炎患者血清及关节液血管生成素样蛋白4、白细胞介素-17、核因子κB受体活化因子配体的临床意义[J]. 实用临床医药杂志, 2022, 8(17): 57-62. doi: 10.7619/jcmp.20220103
[41]	陈娟, 谢军, 孙媛媛, 等. 老年衰弱患者焦虑、抑郁、生活质量状况的分析[J]. 实用临床医药杂志, 2019, 23(4): 73-77. doi: 10.7619/jcmp.201904022
[42]	FINCKH A, GILBERT B, HODKINSON B, et al. Global epidemiology of rheumatoid arthritis[J]. Nat Rev Rheumatol, 2022, 18(10): 591-602.
[43]	WANG X R, HU J J, WU D P. Risk factors for frailty in older adults[J]. Medicine, 2022, 101(34): e30169. doi: 10.1097/MD.0000000000030169

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Prevalence of frailty in patients with rheumatoid arthritis: a systematic review

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