Citation: | WU Guohua, ZHANG Xiaofei, WANG Qi, LI Chao, YAN Xuefang. Relationships of carotid plaque characteristics and hemorheology with disease classification and severity in elderly patients with ischemic stroke[J]. Journal of Clinical Medicine in Practice, 2024, 28(13): 58-62. DOI: 10.7619/jcmp.20240835 |
To analyze the relationships of carotid plaque characteristics and hemorheology with disease classification and severity in elderly patients with ischemic stroke.
A total of 240 elderly patients with ischemic stroke were selected as observation group, and were further divided into different groups based on disease classification [complete anterior circulation infarction (TACI), partial anterior circulation infarction (PACI), posterior circulation infarction (POCI), lacunar infarction (LACI)] and severity of the disease (mild, moderate, and severe); another 60 elderly healthy individuals with physical examinations were selected as control group. The characteristics of carotid artery plaques [carotid intima-media thickness (IMT), number of plaques, maximum length of plaques, and nature of plaques]as well as hemorheology indexes[erythrocyte sedimentation rate (ESR), hematocrit (HCT), plasma fibrinogen (Fib), plasma viscosity, and whole blood viscosity]were measured in all the cases, and the relationships of carotid plaque characteristics and hemorheology with disease classification and severity were analyzed.
The IMT, the number of plaques, maximum diameter of plaques, ESR, HCT, Fib, plasma viscosity, and whole blood viscosity in the observation group were significantly higher than those in the control group (P < 0.05); the IMT, the number of plaques, and maximum diameter of plaques in the LACI group were significantly lower than those in the TACI, PACI, and POCI groups, while the ratios of stable plaques were significantly higher (P < 0.05); the ESR, HCT, Fib, plasma viscosity, and whole blood viscosity in the LACI group were significantly lower than those in the TACI, PACI, and POCI groups (P < 0.05); the IMT, the number of plaques, and maximum diameter of plaques in the mild group were significantly lower than those in the moderate and severe groups, the ratio of stable plaques was significantly higher than that in the moderate and severe groups, the IMT, the number of plaques, and maximum diameter of plaques in the moderate group were significantly lower than those in the severe group (P < 0.05); the ESR, HCT, Fib, plasma viscosity, and whole blood viscosity in the mild group were significantly lower than those in the moderate and severe groups, and the above indicators in the moderate group were significantly lower than those in the severe group (P < 0.05).
The characteristics of carotid artery plaques and hemorheology in elderly patients with ischemic stroke are related to the classification and severity of the disease, and the status of carotid artery plaques and hemorheological abnormalities in elderly patients with TACI, PACI, and POCI types of ischemic stroke are more severe than those of patients with LACI type.
[1] |
林巧茂, 李阔, 项宁, 等. 血清可溶性髓系细胞触发受体-1与老年急性缺血性脑卒中严重程度及预后的关系[J]. 实用老年医学, 2022, 8(8): 827-832. https://www.cnki.com.cn/Article/CJFDTOTAL-SYLA202208018.htm
|
[2] |
衣丽华, 董岩, 郑丽莎, 等. 血清MASP-3、MBL、SDMA对老年急性缺血性脑卒中的诊断价值[J]. 疑难病杂志, 2022, 8(5): 456-460, 474.
|
[3] |
杜立铭, 郭林霞, 刘银芳. 老年急性缺血性脑卒中患者外周血中解聚蛋白样金属蛋白酶-4表达水平与颈动脉斑块不稳定和患者预后的关系[J]. 卒中与神经疾病, 2022, 8(3): 205-209.
|
[4] |
孙丹丹, 陈怡静, 霍禹璇, 等. 颈动脉斑块超声特征与中老年患者缺血性脑卒中的关联性研究[J]. 解放军医学院学报, 2022, 43(1): 15-19.
|
[5] |
刘明全, 杨敏, 黄飞, 等. 老年2型糖尿病伴脑梗死患者血液流变学及凝血功能指标检测及意义[J]. 海南医学院学报, 2018, 24(1): 125-128.
|
[6] |
中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2018[J]. 中华神经科杂志, 2018, 51(9): 666-682. https://www.cnki.com.cn/Article/CJFDTOTAL-XDJB201911024.htm
|
[7] |
张鹏. 脑卒中患者TOAST、OCSP分型与外周血DNA甲基转移酶及MeCp2蛋白水平的关系[J]. 检验医学与临床, 2023, 9(8): 1160-1164.
|
[8] |
王峰. 血清脂蛋白相关磷脂酶A2、同型半胱氨酸、胱抑素C水平与急性脑梗死及其神经功能缺损程度、短期预后的关系研究[J]. 实用心脑肺血管病杂志, 2019, 27(6): 24-29.
|
[9] |
ALTERSBERGER V L, RUSCHE N, MARTINEZ-MAJANDER N, et al. Intravenous thrombolysis in patients with ischemic stroke aged ≥90 years: a cohort study from the TRISP collaboration[J]. Stroke, 2022, 53(12): 3557-3563.
|
[10] |
张艾嘉, 王爽, 王萍, 等. 缺血性脑卒中的病理机制研究进展及中医药防治[J]. 中国实验方剂学杂志, 2020, 26(5): 227-240. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX202005033.htm
|
[11] |
吴勇, 吴应林, 汪声奎. 银杏内酯注射液辅助治疗老年缺血性脑卒中的疗效及对患者神经功能和预后的影响[J]. 河北医药, 2020, 42(15): 2291-2295.
|
[12] |
黄欣, 黄婷, 李娜, 等. 血管内支架介入成形术对老年缺血性脑卒中患者的神经功能及预后的影响[J]. 空军医学杂志, 2019, 35(6): 499-502.
|
[13] |
CHEN X J, XIE Y D, LIANG C L, et al. Tug1 acts on ERK12 signaling pathway to aggravate neuronal damage after acute ischemic stroke[J]. Cell Mol Biol, 2022, 68(1): 51-58.
|
[14] |
康钦, 王豪, 宋嫣, 等. 彩色多普勒超声检测颈动脉内中膜厚度、斑块及颈动脉狭窄对缺血性脑卒中的诊断价值[J]. 实用临床医药杂志, 2019, 23(14): 43-45.
|
[15] |
于洪远, 景淑贤, 景倩. 血栓分子标志物与急性缺血性脑卒中病情严重程度及溶栓预后的相关性[J]. 现代生物医学进展, 2023, 23(8): 1506-1510.
|
[16] |
吕康, 孔伟丽, 付广, 等. 银杏叶提取物注射液联合阿加曲班治疗急性脑梗死的临床研究[J]. 现代药物与临床, 2023, 9(3): 596-601.
|
[17] |
臧卫平, 张志军, 封倩, 等. 盐酸氟西汀联合三七通舒胶囊对缺血性脑卒中老年患者NIHSS评分及血清CGRP、IGF-1水平的影响[J]. 中国老年学杂志, 2021, 41(19): 4178-4181.
|
[18] |
苏健, 徐冰, 宋媛, 等. 脑梗死患者血清炎性因子、同型半胱氨酸与颈动脉内膜中层厚度的关系[J]. 检验医学, 2020, 35(8): 852-853. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYY202008028.htm
|
[19] |
苗亚南. 调脂汤对急性脑梗死患者血液流变学及颈动脉粥样硬化斑块的影响[J]. 新中医, 2022, 8(3): 56-60. https://www.cnki.com.cn/Article/CJFDTOTAL-REND202203011.htm
|
[20] |
徐军鹏, 胡国豪, 黄方剑. 老年急性缺血性脑卒中患者疾病分型和严重程度与颈动脉斑块性质和血液流变学的关系[J]. 中国现代医学杂志, 2019, 29(22): 108-112.
|