Efficacy of 5-Aminolaevulinic acid photodynamic therapy combined with human interferon α-2β in the treatment of condyloma acuminatum

FANG Yuhui; WANG Xinyi; LI Kunpeng; WANG Wei

doi:10.7619/jcmp.20241855

Journal of Clinical Medicine in Practice > 2024 > 28(20): 27-31. > DOI: 10.7619/jcmp.20241855

FANG Yuhui, WANG Xinyi, LI Kunpeng, WANG Wei. Efficacy of 5-Aminolaevulinic acid photodynamic therapy combined with human interferon α-2β in the treatment of condyloma acuminatum[J]. Journal of Clinical Medicine in Practice, 2024, 28(20): 27-31. DOI: 10.7619/jcmp.20241855

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Efficacy of 5-Aminolaevulinic acid photodynamic therapy combined with human interferon α-2β in the treatment of condyloma acuminatum

Department of Dermatology, Fuyang People's Hospital of Anhui Province, Fuyang, Anhui, 236000

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Received Date: May 05, 2024
Revised Date: June 26, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the therapeutic effects of 5-Aminolaevulinic acid photodynamic therapy (ALA-PDT) combined with human interferon α-2β in the treatment of condyloma acuminatum (CA) and its impacts on serum T-cell subsets, chemokine ligand 19 (CCL19), and matrix metalloproteinase-3 (MMP-3) levels.
Methods
A total of 86 patients with CA were enrolled and randomly divided to control group (treated with ALA-PDT alone) and observation group (treated with ALA-PDT combined with human interferon α-2β), with 43 patients in each group. Clinical efficacy, changes in serum T-cell subsets, CCL19, and MMP-3 levels before and after treatment were compared between the two groups. Adverse reactions during treatment were recorded. Patients were followed up for 6 months to record the number of warts and recurrence rate.
Results
The total effective rate of treatment in the observation group was significantly higher than that in the control group (P < 0.05). After treatment, the levels of CD4⁺, CD8⁺, and CD4⁺/CD8⁺ in the observation group were significantly elevated compared to the control group (P < 0.05). Additionally, serum CCL19 levels increased, while MMP-3 levels decreased in the observation group post-treatment compared to the control group (P < 0.05). No significant difference was observed in the incidence of adverse reactions between the two groups (P>0.05). The recurrence rate and the number of average recurrent warts were significantly higher in the control group than in the observation group (P < 0.05).
Conclusion
The combination of ALA-PDT and human interferon α-2β exhibits remarkable efficacy in the treatment of CA, which can effectively regulate serum T-cell subset levels, reduce MMP-3 levels, enhance CCL19 levels, and demonstrates good safety.

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Efficacy of 5-Aminolaevulinic acid photodynamic therapy combined with human interferon α-2β in the treatment of condyloma acuminatum

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