Efficacy of Xingpi Huazhuo Prescription in treating pre-diabetic patients with phlegm-dampness constitution and its influences on blood glucose and renal function indexes

LI Lijuan; WU Jie; SHANG Xinxiu; FENG Weixun

doi:10.7619/jcmp.20242530

Journal of Clinical Medicine in Practice > 2025 > 29(4): 60-63. > DOI: 10.7619/jcmp.20242530

LI Lijuan, WU Jie, SHANG Xinxiu, FENG Weixun. Efficacy of Xingpi Huazhuo Prescription in treating pre-diabetic patients with phlegm-dampness constitution and its influences on blood glucose and renal function indexes[J]. Journal of Clinical Medicine in Practice, 2025, 29(4): 60-63. DOI: 10.7619/jcmp.20242530

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Efficacy of Xingpi Huazhuo Prescription in treating pre-diabetic patients with phlegm-dampness constitution and its influences on blood glucose and renal function indexes

1.
Department of Endocrinology, Shijiazhuang Hospital of Traditional Chinese Medicine, Shijiazhuang, Hebei, 050000
2.
Department of Endocrinology, Hebei Hospital of Traditional Chinese Medicine, Shijiazhuang, Hebei, 050000
3.
Department of Nephrology, Dingzhou People's Hospital of Hebei Province, Dingzhou, Hebei, 073000

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Received Date: June 13, 2024
Revised Date: August 23, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the efficacy of Xingpi Huazhuo Prescription in treating pre-diabetic patients with phlegm-damp constitution and its impacts on blood glucose levels and renal function indicators.
Methods
A total of 104 pre-diabetic patients with phlegm-damp constitution admitted to the hospital between January 2021 and December 2023 were selected and randomly divided into western medicine group (n=52) and combined group (n=52) using a random number table method. The western medicine group received metformin treatment, while the combined group received metformin combined with Xingpi Huazhuo Prescription. Clinical efficacy was recorded after 3 months of treatment, and blood glucose indexes such as [fasting blood glucose (FPG), glycated hemoglobin (HbA1c), and 2-h plasma glucose (2 hPG)] levels, lipid indicators[triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)], and renal function indicators [serum creatinine (Scr), urea nitrogen (BUN), β₂-microglobulin (β₂-MG)] were compared before and after 3 months of treatment.
Results
After 3 months of treatment, the total clinical effectiveness in the combined group was higher than that in the western medicine group (P < 0.05). After 3 months of treatment, the levels of FPG, HbA1c, and 2 hPG decreased in both groups, and the combined group showed lower levels than the western medicine group (P < 0.05). After 3 months of treatment, the levels of TG, TC, and LDL-C decreased in both groups compared with before treatment, and the combined group showed lower levels than the western medicine group (P < 0.05); the levels of HDL-C increased in both groups, and the combined group showed higher levels than the western medicine group (P < 0.05). After 3 months of treatment, the levels of Scr, BUN, and β₂-MG decreased in both groups, with the combined group showing lower levels than the western medicine group (P < 0.05).
Conclusion
In pre-diabetic patients with phlegm-damp constitution, metformin combined with Xingpi Huazhuo Prescription can effectively improve blood glucose levels and exert renal protective effects.
- pre-diabetes,
- Xingpi Huazhuo Prescription,
- phlegm-damp constitution,
- blood glucose,
- renal function,
- blood lipid

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References

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Efficacy of Xingpi Huazhuo Prescription in treating pre-diabetic patients with phlegm-dampness constitution and its influences on blood glucose and renal function indexes

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