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WEN Xuzhi, XU Chunni, HONG Guobiao, LUO Xuexin, CHEN Wenwei. Correlation between the pulmonary immune prognostic index and prognosis of advanced non-small cell lung cancer patients treated with sintilimab[J]. Journal of Clinical Medicine in Practice, 2025, 29(3): 17-21, 29. DOI: 10.7619/jcmp.20242691
Citation: WEN Xuzhi, XU Chunni, HONG Guobiao, LUO Xuexin, CHEN Wenwei. Correlation between the pulmonary immune prognostic index and prognosis of advanced non-small cell lung cancer patients treated with sintilimab[J]. Journal of Clinical Medicine in Practice, 2025, 29(3): 17-21, 29. DOI: 10.7619/jcmp.20242691
shu

Correlation between the pulmonary immune prognostic index and prognosis of advanced non-small cell lung cancer patients treated with sintilimab

  • 1.

    Department of Oncology, Yixing Hospital Affiliated to Jiangsu University, Wuxi, Jiangsu, 214200

  • 2.

    Department of Medical Oncology, the Second Hospital of Shaoxing in Zhejiang Province, Shaoxing, Zhejiang, 312000

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  • Received Date: June 24, 2024
  • Revised Date: September 25, 2024
    Graphical Abstract
    • Abstract
  • Objective 

    To analyze the correlation between the pulmonary immune prognostic index (LIPI) and the prognosis of patients with advanced non-small cell lung cancer (NSCLC) treated with sintilimab.

    Methods 

    A total of 145 patients with advanced NSCLC were selected as study subjects. All patients received treatment with sintilimab, and their clinical baseline data were recorded. According to the LIPI score, patients were divided into low-risk, intermediate-risk, and high-risk groups. The correlation between LIPI and the prognosis of advanced NSCLC patients was analyzed. Factors influencing progression-free survival (PFS) and overall survival (OS) were identified.

    Results 

    Univariate analysis showed that patient age, smoking status, pathological type, clinical stage and LIPI were factors affecting PFS (P < 0.05); age, pathological type, clinical stage and LIPI were factors affecting OS (P < 0.05). Multivariate Logistic regression analysis revealed that age of 60 to 70 years, age > 70 years, adenocarcinoma, stage Ⅳ and high-risk LIPI were independent prognostic factors of PFS (P < 0.05); age > 70 years, poor stage Ⅳ, adenocarcinoma and high-risk LIPI were independent prognostic factors of OS (P < 0.05). LIPI influenced patient's prognosis, with low-risk patients showing better outcomes and longer median PFS and OS.

    Conclusion 

    LIPI is correlated with the prognosis of advanced NSCLC patients treated with sintilimab. Patients with a low-risk LIPI assessment benefit more from sintilimab treatment.

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    • References (16)
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