Flash extraction process of Huangyu Shenshu Granules based on Box-Behnken design-response surface methodology

LI Dan; WAN Li; LI Wei; HE Sijie

doi:10.7619/jcmp.20242825

Journal of Clinical Medicine in Practice > 2024 > 28(24): 20-25. > DOI: 10.7619/jcmp.20242825

LI Dan, WAN Li, LI Wei, HE Sijie. Flash extraction process of Huangyu Shenshu Granules based on Box-Behnken design-response surface methodology[J]. Journal of Clinical Medicine in Practice, 2024, 28(24): 20-25. DOI: 10.7619/jcmp.20242825

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Flash extraction process of Huangyu Shenshu Granules based on Box-Behnken design-response surface methodology

Department of Pharmacy, Maternity and Child Healthcare Hospital of Hubei Province, Wuhan, Hubei, 430070

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Received Date: July 02, 2024
Revised Date: September 05, 2024

Graphical Abstract

Abstract

Abstract

Objective
To optimize the flash extraction process of Huangyu Shenshu Granules based on Box-Behnken design-response surface methodology.
Methods
The extraction yields of morroniside and loganin, as well as the yield of dry extract, were used as evaluation indices. The rotation speed, liquid-solid ratio, and extraction time were selected as the investigation factors. Based on preliminary experiments, combined with Box-Behnken design-response surface methodology, the flash extraction process of Huangyu Shenshu Granules was studied and optimized.
Results
The optimal condition for the flash extraction of Huangyu Shenshu Granules were taking water as the extraction solvent, with a rotation speed of 4, 560 r/min, a liquid-solid ratio of 23 mL/g, and an extraction time of 85 s.
Conclusion
The flash extraction process established based on Box-Behnken design-response surface methodology is rapid and efficient, and suitable for the subsequent industrialization development of Huangyu Shenshu Granules.
- Huangyu Shenshu Granules,
- Box-Behnken design,
- response surface methodology,
- flash extraction,
- liquid-solid ratio,
- morroniside,
- loganin

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References (15)

References

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Flash extraction process of Huangyu Shenshu Granules based on Box-Behnken design-response surface methodology