Therapeutic effect and mechanism of individualized treatment for hypertension patients with coronary heart disease under non-invasive cardiac output measurement

HUANG Haifen; CHEN Qingyong; HE Fang; LI Ren

doi:10.7619/jcmp.20243797

Journal of Clinical Medicine in Practice > 2025 > 29(5): 70-75, 81. > DOI: 10.7619/jcmp.20243797

HUANG Haifen, CHEN Qingyong, HE Fang, LI Ren. Therapeutic effect and mechanism of individualized treatment for hypertension patients with coronary heart disease under non-invasive cardiac output measurement[J]. Journal of Clinical Medicine in Practice, 2025, 29(5): 70-75, 81. DOI: 10.7619/jcmp.20243797

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Therapeutic effect and mechanism of individualized treatment for hypertension patients with coronary heart disease under non-invasive cardiac output measurement

the First People's Hospital of Chenzhou City in Hunan Province, Chenzhou, Hunan, 423000

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Received Date: August 26, 2024
Revised Date: November 21, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the efficacy and mechanism of individualized treatment for hypertension patients with coronary heart disease under non-invasive cardiac output measurement.
Methods
A total of 94 hypertension patients with coronary heart disease in the hospital from January 2020 to August 2022 were selected and randomly divided into two groups, with 47 cases in each group. Control group was treated with conventional treatment, while observation group was treated with individualized treatment under non-invasive cardiac output measurement, and both group were continuously treated for 3 months. Clinical efficacy, the blood pressure control[diastolic blood pressure (DBP), systolic blood pressure (SBP)], cardiac ultrasound parameters[left ventricular end-systolic diameter (LVESD), left ventricular mass index (LVMI), interventricular septal thickness (IVS), left ventricular end-diastolic diameter (LVEDD)], heart rate variability[the standard deviation of the average RR interval (SDANN), the standard deviation of the RR interval of all sinus beats (SDNN), and the proportion of adjacent NN>50 ms in the number of sinus beats (PNN50)], indicators of myocardial injury[α-hydroxybutyrate dehydrogenase (α-HBDH), lactate dehydrogenase (LDH), creatine kinase (CK)], transforming growth factor-β1 (TGF-β1)/pancreatic cancer-deficiency factor (Smads) signaling pathway, and incidence of major adverse cardiovascular events (MACE) were compared between the two groups.
Results
The total effective rate of the observation group was 95.74%, which showed no significant difference compared with 85.11% of the control group (P>0.05). After 1 and 3 months of treatment, the levels of DBP and SBP in both groups were decreased significantly compared with those before treatment (P < 0.05), and the LVMI, IVS, LVEDD and LVESD in the observation group were significantly lower than those in the control group (P < 0.05). After 3 months of treatment, the SDANN, PNN50 and SDNN in observation group were significantly higher than those in control group (P < 0.05), while CK, α-HBDH and LDH as well as the expression levels of TGF-β1RⅠ, TGF-β1RⅡ, Smad1 and Smad2 were significantly lower than those in the control group (P < 0.05). After 3 months of follow-up, the incidence rate of MACE in observation group was 6.38%, which showed no significant difference compared with 14.89% in control group (P>0.05).
Conclusion
Compared with conventional treatment regimen, individualized treatment regimen with non-invasive cardiac output measurement can significantly alleviate myocardial injury, reverse ventricular hypertrophy and improve heart rate variability, and its mechanism may be related to the inhibition of the TGF-β1/Smads signaling pathway.

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References (24)

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Therapeutic effect and mechanism of individualized treatment for hypertension patients with coronary heart disease under non-invasive cardiac output measurement

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