Advance Search
ZHANG Liping, LIU Xiangjie, LIU Xiaoxia, WEI Ting, WANG Yan, LI Qian. Epidemic characteristics and disease burden of drug-resistant tuberculosis cases in the elderly in Wuhan[J]. Journal of Clinical Medicine in Practice, 2025, 29(6): 30-33. DOI: 10.7619/jcmp.20244924
Citation: ZHANG Liping, LIU Xiangjie, LIU Xiaoxia, WEI Ting, WANG Yan, LI Qian. Epidemic characteristics and disease burden of drug-resistant tuberculosis cases in the elderly in Wuhan[J]. Journal of Clinical Medicine in Practice, 2025, 29(6): 30-33. DOI: 10.7619/jcmp.20244924
shu

Epidemic characteristics and disease burden of drug-resistant tuberculosis cases in the elderly in Wuhan

  • 1.

    Department of Geriatrics, Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, 430077

  • 2.

    the First Cardiovascular Ward, Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, 430077

  • 3.

    Wound Repair and Vascular Surgery, Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, 430077

More Information
  • Received Date: October 17, 2024
  • Revised Date: December 30, 2024
    Graphical Abstract
    • Abstract
  • Objective 

    To analyze the epidemiological characteristics and disease burden of drug-resistant tuberculosis cases among elderly patients in Wuhan.

    Methods 

    Clinical data of elderly patients with pulmonary tuberculosis in Wuhan from January 2019 to December 2022 were retrospectively analyzed. Sputum samples were collected for Mycobacterium tuberculosis isolation, and drug susceptibility testing was performed using the proportion method. The epidemiological characteristics of drug-resistant tuberculosis and the direct economic burden of the patients were analyzed.

    Results 

    A total of 972 elderly patients with positive Mycobacterium tuberculosis tests were included. The overall tuberculosis drug resistance rate was 21.19% (206/972). Male, rural residence, lower education level (primary school or below) and retreatment history significantly increased the risk of developing drug-resistant tuberculosis (P < 0.05). The direct economic burden for elderly patients with drug-resistant tuberculosis was 24, 101.52 (8, 283.98, 39, 598.89) RMB, and the indirect economic burden was 1, 858.64 (528.66, 3, 085.26) RMB.

    Conclusion 

    The incidence of drug resistance in elderly tuberculosis is high, and male, rural residence, low education level and tuberculosis retreatment are the risk factors for drug resistance in elderly tuberculosis, and their economic burden is heavy after drug resistance.

    • FullText(HTML)
    • References (25)
  • [1]
    范江静, 龚德华, 万燕萍, 等. 2017—2021年湖南省肺结核流行特征分析[J]. 实用预防医学, 2024, 31(1): 13-16. doi: 10.3969/j.issn.1006-3110.2024.01.004
    [2]
    LI S C, WANG R, YANG Y, et al. Analysis of drug resistance in pulmonary tuberculosis patients with positive sputum tuberculosis culture in NorthEast China[J]. Front Pharmacol, 2023, 14: 1263726.
    [3]
    ASSEFA D G, DEMEMEW Z G, ZELEKE E D, et al. Financial burden of tuberculosis diagnosis and treatment for patients in Ethiopia: a systematic review and meta-analysis[J]. BMC Public Health, 2024, 24(1): 260.
    [4]
    MIIRO E, OLUM R, BALUKU J B. Clinical features, resistance patterns and treatment outcomes of drug-resistant extra-pulmonary tuberculosis: a scoping review[J]. J Clin Tuberc Other Mycobact Dis, 2023, 33: 100390.
    [5]
    DONG Z, WANG Q Q, YU S C, et al. Age-period-cohort analysis of pulmonary tuberculosis reported incidence, China, 2006—2020[J]. Infect Dis Poverty, 2022, 11(1): 85.
    [6]
    中华人民共和国国家卫生和计划生育委员会. 肺结核诊断标准(WS288-2017)[J]. 新发传染病电子杂志, 2018, 3(1): 59-61. doi: 10.3877/j.issn.2096-2738.2018.01.017
    [7]
    邱巍. 结核病诊断实验室检验规程[M]. 北京: 中国文化教育出版社, 2006: 13-58.
    [8]
    唐神结, 高文. 临床结核病学[M]. 2版. 北京: 人民卫生出版社, 2019: 201-202.
    [9]
    麦精兰, 冯雄, 吴克长. 2016—2021年海口市新涂阳肺结核流行病学调查及耐药性监测[J]. 中国国境卫生检疫杂志, 2022, 45(5): 407-409.
    [10]
    张娅, 张婷, 范君, 等. 2011—2022年重庆市老年利福平耐药肺结核患者的流行特征及治疗转归分析[J]. 现代预防医学, 2024, 51(6): 1099-1104.
    [11]
    刘广天, 潘莉, 佟岩, 等. 宁夏地区耐药肺结核流行特征[J]. 现代预防医学, 2020, 47(15): 2695-2699.
    [12]
    叶慧, 缪星国, 宋启发, 等. 温州市利福平耐药肺结核流行病学特征(2015—2020年)[J]. 国际流行病学传染病学杂志, 2022, 49(5): 320-324. doi: 10.3760/cma.j.cn331340-20220526-00121
    [13]
    REN Y L, CHEN B, ZHAO J Y, et al. Trends of rifampicin resistance in patients with pulmonary tuberculosis: a longitudinal analysis based on drug resistance screening in Eastern China between 2015 and 2019[J]. Infect Drug Resist, 2022, 15: 7707-7717.
    [14]
    赵慧, 王志锐, 巨韩芳, 等. 2020年天津市肺结核耐药流行病学特征及影响因素分析[J]. 疾病监测, 2023, 38(1): 57-63.
    [15]
    LIU L, ZHAO X J, WU X Y, et al. Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Hainan, China: from 2014 to 2019[J]. BMC Microbiol, 2021, 21(1): 185.
    [16]
    HU Y, LIU J, SHEN J, et al. Genotyping and molecular characterization of fluoroquinolone′s resistance among multidrug-resistant Mycobacterium tuberculosis in southwest of China[J]. Microb Drug Resist, 2021, 27(7): 865-870.
    [17]
    黄海荣. 多举措并举提高结核病诊疗水平[J]. 实用医学杂志, 2022, 38(6): 660-663. doi: 10.3969/j.issn.1006-5725.2022.06.002
    [18]
    康宏云, 商临萍, 范月玲, 等. 2015—2020年山西省耐药结核病流行特征与空间聚集性分析[J]. 疾病监测, 2023, 38(1): 34-38.
    [19]
    杨新宇, 陈双双, 易俊莉, 等. 北京市2019年流动人口肺结核流行特征及耐药情况分析[J]. 中华流行病学杂志, 2023, 44(6): 949-953.
    [20]
    郝冬青, 李涛, 黄飞, 等. 我国西部地区肺结核患者家庭经济负担现况调查[J]. 中国防痨杂志, 2023, 45(11): 1021-1030.
    [21]
    吴波, 刘英, 廖文平, 等. 重庆市四区县肺结核患者经济负担分析[J]. 中国防痨杂志, 2022, 44(4): 390-396.
    [22]
    AKALU T Y, CLEMENTS A C A, WOLDE H F, et al. Economic burden of multidrug-resistant tuberculosis on patients and households: a global systematic review and meta-analysis[J]. Sci Rep, 2023, 13(1): 22361.
    [23]
    张礼亮, 张婧怡, 田佳帅, 等. 肺结核患者疾病负担现状及影响因素研究[J]. 卫生经济研究, 2024, 41(5): 36-40.
    [24]
    律彤, 杨云斌, 潘颖, 等. 云南省利福平耐药肺结核患者经济负担现状及影响因素分析[J]. 中国防痨杂志, 2023, 45(11): 1031-1037.
    [25]
    FEBI A R, MANU M K, MOHAPATRA A K, et al. Psychological stress and health-related quality of life among tuberculosis patients: a prospective cohort study[J]. ERJ Open Res, 2021, 7(3): 00251-02021.
    • Related Articles

  • Cited by

    Periodical cited type(28)

    1. 冯巧巧，纪红英，宋元明，韦艺霖，樊红延，温清. 奥氮平口溶膜在中国健康受试者中的生物等效性研究. 中国临床药理学杂志. 2023(03): 415-419 .
    2. 张燕，崔小花，苏艳丽，杨柳，丁靖，蒙卓成，杨瀚. 奥氮平治疗精神分裂症患者的血药浓度参考范围研究. 中国医院用药评价与分析. 2023(06): 661-664 .
    3. 潘永花，李成雄，王雪. 吸氧联合胞二磷胆碱对精神分裂症患者无抽搐电休克治疗后短时记忆、计算及言语功能的影响. 神经损伤与功能重建. 2022(02): 120-122 .
    4. 张燕，崔小花，苏艳丽，丁靖，王慧，孙丽莎. 奥氮平不同给药次数治疗精神分裂症的有效性及安全性. 中国医院药学杂志. 2022(20): 2162-2165+2194 .
    5. 张富松，朱雅超，解凯，陈延会，邵明龙. 阿立哌唑与喹硫平治疗晚发型精神分裂症的临床疗效及安全性评价. 国际精神病学杂志. 2021(04): 624-627 .
    6. 冯新梅. 奥氮平治疗精神分裂症对患者症状、安全性评分及相关血清因子的影响. 临床荟萃. 2021(12): 1114-1117 .
    7. 刘明官，张国嘉. 奥氮平治疗老年精神分裂症对患者血脂水平和认知功能的影响. 现代医学与健康研究电子杂志. 2021(23): 57-59 .
    8. 易云洁，石广念. 老年精神分裂症患者的奥氮平和鼓圈音乐治疗概况. 内科. 2021(06): 777-779+820 .
    9. 姚慧敏. 精神分裂症患者长期服用抗精神病药物超声检查结果分析. 现代诊断与治疗. 2020(02): 212-214 .
    10. 狄丽丽，佟久芬，李超，刘秀花，付玉忠. 喹硫平联合奥氮平改善老年精神分裂症患者认知功能和生活能力的临床疗效. 心理月刊. 2020(11): 26-27 .
    11. 曾仕富. 奥氮平应用于儿童精神分裂症治疗的临床疗效观察. 中外医疗. 2020(13): 96-98 .
    12. 王敬巍，王永良. 无抽搐电休克联合奥氮平治疗精神分裂症患者的临床效果. 中国民康医学. 2020(24): 76-78 .
    13. 丛文. 奥氮平对精神分裂症患者认知功能的影响分析. 中国医药指南. 2019(01): 131-132 .
    14. 刘丽辉. 氨磺必利与奥氮平治疗首发男性精神分裂症疗效及对糖脂代谢的影响. 中国药物与临床. 2019(01): 63-66 .
    15. 李福金，王飞，李红丽，叶百维. 病区内易操作易实施康复训练配合奥氮平口服对慢性精神分裂症患者社会及认知功能的影响. 中国医学创新. 2019(09): 153-156 .
    16. 刘英. 积极心理支持结合分层护理模式对老年精神分裂症患者的影响分析. 实用临床医药杂志. 2019(08): 108-110+114 . 本站查看
    17. 肖健，高静，李金浩. MECT联合第二代精神药物对精神分裂症患者疗效分析. 世界最新医学信息文摘. 2019(37): 10-13 .
    18. 高作惠，严峻，李毅，胡晓华，李赋，王宗琴. 吡拉西坦联合氨磺必利对阴性症状为主的精神分裂症患者的前瞻性记忆和认知功能的影响. 临床精神医学杂志. 2019(03): 204-207 .
    19. 蒋光芬，王任昌，刘颖. 奥氮平对伴或不伴代谢综合征的精神分裂症病人认知功能的差异性影响分析. 蚌埠医学院学报. 2019(08): 1027-1029 .
    20. 万萍，刘亮，张萍，张忠东. 奥氮平在精神分裂症中的血清药物浓度/剂量比影响因素研究. 中国临床药理学与治疗学. 2019(09): 1024-1029 .
    21. 费沛. 奥氮平与氟哌啶醇治疗精神分裂症的效果比较及对血清炎症因子的影响. 实用医药杂志. 2019(11): 997-1000 .
    22. 倪清碧. 奥氮平对老年精神分裂症患者认知功能的改善作用. 临床合理用药杂志. 2019(34): 71-72 .
    23. 张俊. 老年精神分裂症的药物治疗效果研究. 中国社区医师. 2018(02): 77+80 .
    24. 张云琼. 奥氮平治疗老年精神分裂症患者的临床效果及对认知功能的改善作用. 中外医学研究. 2018(16): 9-11 .
    25. 姜登发，匡晓丽. 奥氮平辅助治疗老年精神分裂症伴抑郁52例的临床效果分析. 心理月刊. 2018(04): 7-8 .
    26. 廖国俊，刘世中，黄志军，严华，刘陈莎. 奥氮平治疗老年精神分裂症患者的临床疗效及对认知功能的改善作用分析. 当代医学. 2018(31): 104-106 .
    27. 张明松，张目，邢广照. 奥氮平联合无抽搐电休克治疗精神分裂症的效果观察. 中国民康医学. 2018(22): 74-76 .
    28. 安培玉，孙杰峰，段惠峰，甘景梨. 奥氮平与氟哌啶醇改善老年精神分裂症精神症状及认知功能的差异性研究. 华南国防医学杂志. 2017(11): 723-725+743 .

    Other cited types(3)

Catalog

    Get Citation
    PDF
    XML
    Article views (24) PDF downloads (4) Cited by(31)
    Turn off MathJax
    Article Contents
    Abstract
    References

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return