EXPRESSION OF P_(16) PROTEIN IN SQUAMOUS CELL CARCINOMA OF ESOPHAGUS AND ITS CLINICAL SIGNIFICANCE

to study the expression of p16 protein in esphageal squamous cell carcima (escc) and itsclinicoodringical swificance, the ewion of p16 protein was analyzed by forstochedcal staining (s -p) using for - melin fixed, paraffin ededded sectbo of 88 cases with invasive squamous cell carioma of esoph-agus. expression of p16 protein was detected in 55. 68 % (49/88) of esccs. the opnaion wi correla ed withthe un histologc grade (grade 185. 71% (18/21), ii 55. 13% (16/29), iii39. 47% (15/38) (p 0.01) and lymph nede metastased) positive 36. 3% (12/33), negtive 67. 27% (37/55) (p 0.01). theresults suggst that the expression of p16 protein in rm an favorable prognosis of the lesion.