THE EXPERIMENT AND CLINICAL STUDY IN TRENTINGMAMMARY GLAND HYPERPLASIA WITH SERIAL RUPI MIXTURE

Aim: To observe the therapeutic effects by timed agtninistration of serial Rupi and to clarify its functional mech-anism. Method: Making rats' mammary gland hyperplasia models by estradioli benzoas, random divided into control group,denzoas group benzoas plus Tiandongsu tablets group, denzoas plus traditional Chinese medcine big dose group and small dose group, respectively administration of Tiandongsu oral solution or timed administration of serial Rupi mizture. According to fe-male menstrual cycle, clinical cases were randomly divided into the threatment group and the control group, ropectively timed administration of serial Rupi mizture or Tiandongsu tablets. ResuIts: The medicine can reduce hyperplasia form changes of ex-Perimental rat's mammary tissues, the number of luboli mamma, gland bubbles, and breast enlargemant value. It can also reduce benzoas content in experimental rat's blood, its function obviously better than Tiandongsu tablets (P 0.05). Total effective rate of timed administration by serial Rupi mizture to cIinical mammary gland hyperplasia is 88. 8%, which has marked significance (P0.01) compared with Tiandongsu tablets. Conclusion: Timed administration of serial Rupi mizture has better therapeutic effects on mammary gland hyperplasia, which can obviously reduce the hyperplasia form changes of ex-perimental rats' mammary glang tissues.