CLINICAL RESEARCH ON APROTININ REDUCING LUNG INJURYDURING CARDIOPULMONARY BYPASS

Objective:To study the effect of Aprotinin on lung injury during cardiopulmonary bypass (CPB).Methods:24 cases were randomly divided into two groups: control group (n=12) and experimental group (n=12).Blood samples were taken from the left and right atrium before CPB and after CPB to deterimine platelet and white cell count. Meanwhile , eodothelin(ET),thromboxane B 2(TXB 2) and 6Keto- prostaglandin F 1α (6-Keto-PGF 1α ),lung function were measured.Results: It showed that the platelet and white cells aggregae in the control group,the ET,TXB 2, TXB 2/6-Keto-PGF 1α ,RI were significantly lower in the experimental group than in control group during the post-CPB. Conclusion: This study demonstrated that Aprotinin can obviously reduce lung injury after cardipulmonary bypass.