急性胰腺炎患者凝血功能指标改变的临床意义

殷跃文, 袁诚

殷跃文, 袁诚. 急性胰腺炎患者凝血功能指标改变的临床意义[J]. 实用临床医药杂志, 2014, (15): 150-152. DOI: 10.7619/jcmp.201415052
引用本文: 殷跃文, 袁诚. 急性胰腺炎患者凝血功能指标改变的临床意义[J]. 实用临床医药杂志, 2014, (15): 150-152. DOI: 10.7619/jcmp.201415052
YIN Yuewen, YUAN cheng. Clinical significance of coagulation functional change in patients with acute pancreatitis[J]. Journal of Clinical Medicine in Practice, 2014, (15): 150-152. DOI: 10.7619/jcmp.201415052
Citation: YIN Yuewen, YUAN cheng. Clinical significance of coagulation functional change in patients with acute pancreatitis[J]. Journal of Clinical Medicine in Practice, 2014, (15): 150-152. DOI: 10.7619/jcmp.201415052

急性胰腺炎患者凝血功能指标改变的临床意义

基金项目: 中国高校医学期刊临床专项资金
详细信息
  • 中图分类号: R657.5

Clinical significance of coagulation functional change in patients with acute pancreatitis

  • 摘要: 目的:探讨急性胰腺炎(AP)患者凝血功能指标改变的临床意义。方法选取本院消化科治疗的AP 患者240例,根据病情程度分为轻型胰腺炎组(MAP 组)169例和重型胰腺炎组(SAP 组)71例,对照组为同期本院体检健康者180例。检测3组的部分凝血活酶活化时间(APTT)、凝血酶原时间国际标准化指数(INR)、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D 二聚体(D-dimer)、抗凝血酶-Ⅲ(AT-Ⅲ)和血小板计数(PLT)水平。结果 SAP 组的 APTT、INR、PT、TT、FIB 及 D-dimer 均显著高于 MAP 组及对照组(P <0.01),AT-Ⅲ和 PLT 水平均显著低于 MAP 组及对照组(P <0.01);SAP 组与 MAP组 APACHEⅡ评分比较差异有显著统计学意义(P <0.01)。SAP组的PT、APPT、D-dimer与APACHEⅡ评分呈正相关(P <0.05);AT-Ⅲ活性、PLT 与 APACHEⅡ评分呈负相关(P <0.05)。结论 AP 患者的凝血功能改变与病情严重程度相关,相关指标测定可提高疾病预后判断准确性。
    Abstract: Objective To investigate the change of coagulation function in patients with a-cute pancreatitis and its clinical significance for prognosis.Methods 240 patients with acute pan-creatitis were divided in to moderate acute pancreatitis (MAP)group and severe acute pancreatitis (SAP)group (169 and 71,respectively),another 180 subjects underwent health examination dur-ing same period were selected into control group.Results Levels of APTT,INR,PT,TT,FIB and D-dimer in SAP group were higher than those in MAP group and control group (P <0.01);levels of AT-Ⅲ and PLT in SAP group were lower those in MAP and control group (P <0.01). The level of PT,APPT,D-dimer were positively correlated with APACHE Ⅱ score in SAP group (P <0.05),and level of AT-Ⅲ and PLT were negatively correlated with APACHE Ⅱ score (P <0.05).Conclusion Regular detection of coagulation functional change is potentially helpful for prognosis of patients with acute pancreatitis.
  • 期刊类型引用(1)

    1. 姚让勇,陈贤坤,陈小华,龙凯,李华展,冯烨,陈金妮,冯昌慧. 腹部烫熨联合大承气汤加减灌肠治疗重症监护室患者胃肠功能障碍的临床观察. 实用临床医药杂志. 2023(14): 99-103 . 本站查看

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出版历程
  • 发布日期:  2014-09-10

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