Abstract: Objective To explore clinical application of comprehensive nursing intervention for severe community acquired pneumonia (SCAP) treated by non invasive positive pressure ventilation (NIPPV).Methods A total of 50 SCAP patients with respiratory failure in our hospital were selected as research objects,and were randomly divided into observation group and control group,with 25 cases in each group.Patients in both groups were given oxygen inhalation,anti-inflammatory therapy,removing phlegm,relieving asthma,correcting water and electrolyte disorders and other conventional treatment,and BiPAP ventilator was used for NIPPV.Control group was given routine nursing,and the observation group added comprehensive nursing intervention.The pH value before and after ventilation,arterial oxygen pressure p(O2),partial pressure of carbon dioxide p(CO2),arterial oxygen saturation (SaO2) were determined,and lung function before and after ventilation forced expiratory volume in one second (FEV1),ratio of FEV1 and forced vital capacity (FEV1/FVC),FEV1％ predicted value were measured.Respiratory rate(RR),and heart rate (HR) changes before and after ventilation were recorded.Results The pH value,p (O2),SaO2,p (CO2),FEV1,FEV1/FVC,,FEV1％,HR and RR in the observation group were better than those in the control group,and there was statistical significant difference (P ＜ 0.05).Conclusion Based on the treatment of NIPPV for SCAP combined with respiratory failure patients,comprehensive nursing intervention can improve ventilation,blood oxygen saturation,and respiratory function.