Abstract: Objective To investigate effect of nonverbal psychological intervention on emotional state of ICU awake patients with intubation.Methods A total of 114 ICU awake patients with intubation were divided into two groups,the control group with 57 patients treated with conventional care,while the observation group with 57 cases added nonverbal psychological care.Emotional state and quality of life after nursing of two groups were compared.Results Before intubation,the difference in HAMA,HAMD score of two groups was not significant (P ＞ 0.05);HAMA,HAMD score decreased significantly compared with the control group at 3,7 d of intubation and when extubation (P ＜ 0.05).There was no significant difference in quality of life scores before intubation (P ＞ O.05),but it was significantly increased in the observation group at 3,7 d after intubation compared with the control group (P ＜ 0.05).There was no significant difference in two groups before intubation in NOS,5-HT content (P ＞ 0.05),but they were significantly lower than the control group,and the result revealed significant difference (P ＜ 0.05).Conclusion Nonverbal psychological intervention can improve bad emotion and quality of life of ICU awake patients.