Abstract: Objective To investigate the expression characteristics and clinical significance of homocysteine(Hcy)and hypersensitive C reactive protein(hs-CRP)in serum of patients with coronary atherosclerotic heart disease(CHD). Methods A total of 105 patients who were hospitalized in the Department of Cardiology of Poyang Donghu Hospital were selected as study subjects, and were selected as CHD group. According to the different types of CHD, the patients were divided into three groups: stable angina pectoris(SAP)group(n=42), unstable angina pectoris(UAP)group(n=36)and acute myocardial infarction(AMI)group(n=27). According to the degree of coronary stenosis, CHD patients were divided into moderate group(n=67)and severe group(n=38). In addition, 30 healthy volunteers for physical examination in the same period were selected as the healthy group. The serum Hcy and hs-CRP levels of healthy group and different subgroups of CHD were measured and compared. The correlations among Hcy, hs-CRP and the degree of coronary stenosis in CHD patients were analyzed by Pearson analysis. Results The levels of Hcy and hs-CRP in SAP group, UAP group and AMI group were significantly higher than those in healthy group(P<0.05). The level of Hcy was gradually increased in SAP group, UAP group and AMI group(P<0.05). The - level of hs-CRP in AMI group was significantly higher than that in SAP group and UAP group(P<0.05). The serum Hcy and hs-CRP levelsin moderate and severe CHD groups were significantly higher than those in healthy group(P<0.05), and the severe group was significantly higher than moderate group(P<0.05). Pearson analysis showed that Hcy was positively correlated with hs-CRP in CHD patients(r= 0.547, P< 0.05), There was a positive correlation between Hcy, hs-CRP and the degree of coronary stenosis(r=0.705, 0.438, P<0.05). Conclusion Serum Hcy and hs-CRP levels are closely related to occurrence of CHD and positively related to the degree of coronary stenosis. The detection of Hcy and hs-CRP in serum is of great value to the diagnosis and risk prediction of CHD.