Effect of Wumei Decoction combined with metformin on glucose metabolism and insulin resistance index in patients with type 2 diabetes mellitus
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摘要: 目的 探讨乌梅汤联合二甲双胍对2型糖尿病患者糖代谢和胰岛素抵抗指数(HOMA-IR)的影响。 方法 将102例2型糖尿病患者随机分为对照组(n=51)和联合组(n=51)。对照组给予二甲双胍治疗,联合组在对照组基础上给予乌梅汤治疗,比较2组治疗前后糖代谢因子、胰岛功能指标、中医证候积分及临床疗效。 结果 2组治疗后空腹血糖(FBG)、餐后2 h血糖(2 hPG)及糖化血红蛋白(HbA1c)水平均下降,且联合组上述指标均低于对照组,差异有统计学意义(P<0.05)。2组治疗后HOMA-IR和空腹胰岛素(FINS)水平均降低,胰岛β细胞功能(HOMA-β)水平升高,且联合组HOMA-IR、FINS低于对照组, HOMA-β高于对照组,差异有统计学意义(P<0.05)。治疗后,联合组中医证候积分低于对照组,总有效率高于对照组,差异有统计学意义(P<0.05)。 结论 乌梅汤联合二甲双胍治疗2型糖尿病效果显著,可有效控制血糖水平,减轻胰岛素抵抗,促进胰岛细胞功能恢复。Abstract: Objective To investigate the effect of Wumei Decoction combined with metformin on glucose metabolism and homeostasis model assessment of insulin resistance(HOMA-IR)in patients with type 2 diabetes. Methods Totally 102 patients with type 2 diabetes were randomly divided into control group(n=51)and combination group(n=51). The control group was treated with metformin, and the combination group was treated with Wumei Decoction on the basis of the control group. Glucose metabolites factors, islet function indicators, scores of traditional Chinese medicine(TCM)syndrome and clinical efficacy before and after treatment were compared between the two groups. Results After treatment, the levels of fasting blood glucose(FBG), 2 h postprandial blood glucose(2 hPG)and glycosylated hemoglobin(HbA1c)decreased significantly in both groups, and these indexes in the combination group were significantly lower than those in the control group(P<0.05). After treatment, levels of HOMA-IR andfasting insulin(FINS)reduced significantly in both groups, while homeostasis model assessment of islet β cell(HOMA-β)level increased significantly in both groups. The levels of HOMA-IR and FINS in the combination group were significantly lower than those in the control group, while HOMA-β level was significantly higher than that in the control group(P<0.05). After treatment, the score of TCM syndrome in the combination group was significantly lower than that of the control group, while total effective rate was significantly higher than that of the control group(P<0.05). Conclusion Wumei Decoction combined with metformin is effective in the- treatment of patients with type 2 diabetes, which can effectively control blood glucose level, alleviate insulin resistance and promote the recovery of islet cell function.
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段玉敏, 王宾, 王尚农. 运动处方联合二甲双胍对初治肥胖2型糖尿病患者RBP4水平及HOMA-IR指数的影响[J]. 现代医学, 2018, 46(5): 518-523. 张卫欢, 李秋云, 杨春伟, 等. 大柴胡汤加减联合利拉鲁肽对肥胖2型糖尿病患者胰岛素抵抗、β-细胞功能和低度炎症反应的影响[J]. 现代中西医结合杂志, 2018, 27(1): 23-26 , 30.
中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J]. 中国实用内科杂志, 2018, 38(4): 292-344. 郑筱萸. 中药新药临床研究指导原则[M]. 北京: 中国医药科技出版社, 2002: 12-15. 曹睿, 钟旭, 蒋洪梅, 等. 四逆汤加减对老年2型糖尿病患者糖代谢、脂代谢和葡萄糖转运蛋白4的影响[J]. 世界中医药, 2018, 13(12): 102-105. 张卫欢, 李秋云, 杨春伟, 等. 大柴胡汤加减联合利拉鲁肽对肥胖2型糖尿病患者胰岛素抵抗、β-细胞功能和低度炎症反应的影响[J]. 现代中西医结合杂志, 2018, 17(27): 23-26. 赖根祥, 周秀娟, 金国林. 利培酮联合二甲双胍对精神分裂症合并2型糖尿病患者骨代谢胰岛素及肾功能的影响[J]. 广东医学, 2019, 17(17): 230-233. 和明丽, 丁奇龙, 王俊军. 利格列汀联合二甲双胍治疗超重和肥胖2型糖尿病患者的疗效及对血清脂肪因子变化的影响[J]. 中国医师杂志, 2020, 22(4): 589-592. 郑利星. 加减乌梅汤联合盐酸二甲双胍治疗2型糖尿病的临床研究[J]. 山西医药杂志, 2017, 46(23): 2835-2837. 刘曙艳, 周雪红, 李勇峰. 沙格列汀联合二甲双胍对新诊断2型糖尿病患者血清炎症因子及胰岛β细胞功能的影响分析[J]. 中南医学科学杂志, 2019, 27(28): 2321-2323. 刘佳, 崔旭红, 王丽艳, 等. 预混胰岛素联合二甲双胍对新诊断2型糖尿病患者胰岛功能恢复的影响[J]. 河北医学, 2019, 12(27): 859-861. 王艳妮, 李转霞. 二甲双胍联合利拉鲁肽对2型糖尿病合并非酒精性脂肪肝患者胰岛β细胞功能、肝功能及外周血Treg细胞的影响[J]. 医学临床研究, 2018, 18(1): 11-14. 史晓荻, 魏志杰. SGLT-2抑制剂联合常规降糖治疗对2型糖尿病患者血管内皮功能的影响[J]. 安徽医学, 2019, 41(1): 219-221. 谈晓娅, 童强. 格列美脲联合二甲双胍对初诊2型糖尿病患者糖脂代谢、胰岛功能及血清miR-126表达的影响[J]. 中国药房, 2018, 622(4): 505-508. 吴玉兰. 六味地黄丸加减对2型糖尿病患者免疫功能、白细胞介素-6、肿瘤坏死因子-α及临床预后的影响[J]. 中国卫生检验杂志, 2018, 28(23): 2888-2890. -
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