利伐沙班预防腹腔镜手术后深静脉血栓形成的效果观察

韩博; 任麦芳; 王湘辉; 董建新; 王卫刚

doi:10.7619/jcmp.202024026

利伐沙班预防腹腔镜手术后深静脉血栓形成的效果观察

1. 陕西省西安国际医学中心医院消化外科, 陕西西安, 710100;
2. 陕西省康复医院肿瘤科, 陕西西安, 710065

基金项目:

陕西省自然科学基础研究计划项目(2019JQ-536)

详细信息

通讯作者:
王卫刚, E-mail: 280677234@qq.com

中图分类号: R61;R543
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出版历程
- 收稿日期: 2020-11-11
- 网络出版日期: 2020-12-29

Effect of rivaroxaban in preventing formation of deep venous thrombosis after laparoscopic surgery

1. Department of Digestive Surgery, Xi'an International Medical Center Hospital, Xi'an, Shaanxi, 710100;
2. Department of Oncology, Shaanxi Provincial Rehabilitation Hospital, Xi'an, Shaanxi, 710065

摘要

摘要: 目的观察利伐沙班预防腹腔镜手术后深静脉血栓形成(DVT)的效果。方法选取60例普通外科患者作为研究对象,采用随机投掷法分为对照组和研究组,每组30例。对照组采用低分子肝素钠治疗,研究组采用利伐沙班治疗,比较2组DVT发生率和手术前后D-二聚体、纤维蛋白降解产物(FDP)、凝血指标［活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)和纤维蛋白原(FIB)］、组织型纤溶酶原激活剂(t-PA)、纤溶酶原激活抑制物-1(PAI-1)水平。结果术后,研究组DVT发生率低于对照组,但差异无统计学意义(P>0.05)。术前,2组D-二聚体、FDP水平比较,差异无统计学意义(P>0.05); 术后,研究组D-二聚体、FDP水平低于对照组,差异有统计学意义(P<0.05)。术前, 2组APTT、PT、FIB、t-PA、PAI-1水平比较,差异无统计学意义(P>0.05); 术后24 h时,研究组APTT、PT、FIB、t-PA水平高于对照组, PAI-1水平低于对照组,差异有统计学意义(P<0.05)。结论利伐沙班可降低普通外科腹腔镜手术后DVT风险,改善患者凝血指标水平。
- 利伐沙班 /
- 普通外科 /
- 腹腔镜手术 /
- D-二聚体 /
- 凝血指标
Abstract: Objective To observe effect of rivaroxaban in preventing formation of deep venous thrombosis(DVT)after laparoscopic surgery. Methods A total of 60 patients in general surgery department were selected as research objects, and were divided into control group and study group according to random throwing method. The control group(n=30)was given low molecular weight heparin sodium treatment, and the study group(n=30)was given rivaroxaban. The incidence of DVT, D-dimer, fibrinogen degradation product(FDP), thrombin indexes［activated partial thromboplastin time(APTT), prothrombin time(PT)and fibrinogen(FIB)］, tissue-type plasminogen activator(t-PA), plasminogen activator inhibitor-1(PAI-1)levels before and after surgery were compared. Results The incidence of DVT in the study group was lower than that in the control group, but there was no significant difference in comparison(P>0.05). There were no significant differences in the preoperative D-dimer level and FDP level between the two groups(P>0.05), D-dimer level and FDP level in the study group were significantly lower than those in the control group(P<0.05). There were no significant differences in the levels of APTT, PT, and FIB, t-PA and PAI-1 between the two groups before surgery(P>0.05). The APTT, PT, FIB and t-PA levels at 24 h after operation were significantly higher than those in the control group, and PAI-1 level was significantly lower than that in the control group(P>0.05). Conclusion Rivaroxaban can reduce the risk of DVT formation after laparoscopic surgery in general surgery department and improve coagulation indicators.
- rivaroxaban /
- general surgery /
- laparoscopic surgery /
- D-dimer /
- coagulation indexes

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