质子泵抑制剂联合雷尼替丁对消化性溃疡的治疗效果及对谷胱甘肽过氧化物酶、脂质过氧化物水平的影响

李红; 杨龙宝; 赵刚; 马师洋; 董蕾; 王进海

doi:10.7619/jcmp.20212263

质子泵抑制剂联合雷尼替丁对消化性溃疡的治疗效果及对谷胱甘肽过氧化物酶、脂质过氧化物水平的影响

Efficacy of proton pump inhibitors plus ranitidine in treating patients with peptic ulcers and its effects on levels of glutathione peroxidase and lipid peroxides

摘要

摘要:
目的观察质子泵抑制剂联合雷尼替丁对消化性溃疡患者的治疗效果及对谷胱甘肽过氧化物酶（GSH-Px）、脂质过氧化物（LPO）水平的影响。
方法选取120例消化性溃疡患者作为研究对象，随机分为雷尼替丁组、联合治疗组，每组60例。雷尼替丁组采用雷尼替丁治疗，联合治疗组采用质子泵抑制剂联合雷尼替丁治疗。检测2组患者的H⁺-K⁺-ATP酶活性、胃内酸碱度以及GSH-Px、LPO、白细胞介素（IL）-17、IL-6、IL-8水平，并比较2组患者的治疗有效率、不良反应发生率。
结果治疗后，联合治疗组H⁺-K⁺-ATP酶活性低于雷尼替丁组，胃内酸碱度（pH值）高于雷尼替丁组，差异有统计学意义（P < 0.05）。治疗后，联合治疗组IL-17、IL-6、IL-8、LPO、CD8⁺水平低于雷尼替丁组，GSH-Px、CD3⁺、CD4⁺水平高于雷尼替丁组，差异有统计学意义（P < 0.05）。联合治疗组治疗总有效率高于雷尼替丁组，差异有统计学意义（P < 0.05）。
结论质子泵抑制剂联合雷尼替丁治疗消化性溃疡效果显著，能够调控GSH-Px、LPO水平，提高患者自身免疫力，抑制炎症反应，减轻氧化应激损伤，改善治疗效果。

Abstract:
Objective To observe the effects of proton pump inhibitors combined with ranitidine in treating patients with peptic ulcers and its effects on the levels of glutathione peroxidase (GSH Px) and lipid peroxides (LPO).
Methods A total of 120 patients with peptic ulcer were selected and randomly divided into ranitidine group and combined treatment group, with 60 cases in each group. Ranitidine group was treated with ranitidine, and combined treatment group was treated proton pump inhibitor combined with ranitidine. H⁺-K⁺-ATPase activity and gastric pH level, GSH-Px, LPO level, interleukin (IL-17), IL-6 and IL-8 levels of patients in the two groups were detected. The effective rate and incidence of adverse reactions were compared between the two groups.
Results After treatment, compared with the ranitidine group, H⁺-K⁺-ATPase activity was lower and gastric pH value was higher that those in the combined treatment group (P < 0.05). After treatment, compared with the ranitidine group, the levels of IL-17, IL-6, IL-8, LPO and CD8⁺ were lower in the combined treatment group, while the levels of GSH-Px, CD3⁺ and CD4⁺ were higher in the combined treatment group (P < 0.05). The total effective rate in the combined treatment group was higher than that in the ranitidine group (P < 0.05).
Conclusion The use of proton pump inhibitors combined with ranitidine has a significant effect in treating patients with peptic ulcer, and can regulate the level of GSH-Px and LPO, improve self-immunity, inhibit inflammatory reaction, relieve the damage of oxidative stress, and improve the therapeutic effect.

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