Effect of dexmedetomidine combined with different doses of sufentanil on airway response of patients with adenoidectomy
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摘要:目的
探讨右美托咪定联合不同剂量舒芬太尼对腺样体切除术中气道反应的影响。
方法选取择期行全身静脉麻醉下扁桃体腺样体切除患儿113例，按照舒芬太尼剂量进行分组。分析患儿的生命体征变化、气道反应差异以及苏醒后的呛咳现象。
结果右美托咪定联合低剂量舒芬太尼下，患儿心率和平均动脉压水平高于其他剂量组，过高剂量的舒芬太尼下，患儿心率和平均动脉压水平远低于其他组，差异有统计学意义（P < 0.05）；舒芬太尼剂量增加，患儿气道压峰值降低，同时患儿苏醒后呛咳发生率以及躁动发生率降低。
结论右美托咪定联合不同剂量舒芬太尼能够抑制腺样体切除术中气道反应，并且随着舒芬太尼剂量的增加，抑制效果增强。
Abstract:ObjectiveTo investigate the effect of dexmedetomidine combined with different doses of sufentanil on airway response of child patients with adenoidectomy.
MethodsA total of 113 child patients with selective adenotonsillectomy under general intravenous anesthesia were selected and divided into different groups according to the dose of sufentanil. The change of vital signs, differences of airway response and choking after awakening of child patients were analyzed.
ResultsIn the combination of dexmedetomidine and low-dose sufentanil, the heart rate and mean arterial pressure of child patients were significantly higher than those with dexmedetomidine and other doses of sufentanil, and excessive high-dose sufentanil led to the significant reduction of heart rate and mean arterial pressure of child patients than those of the other groups (P < 0.05); with the increase of dose of sufentanil, the peak airway pressure decreased, and the incidence rates of choking and agitation after awakening decreased as well.
ConclusionDexmedetomidine combined with different doses of sufentanil can inhibit airway response during adenoidectomy, and the inhibitory effect is better with the increase of dose of sufentanil.
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Keywords:
- dexmedetomidine /
- sufentanil /
- adenoidectomy /
- airway response
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表 1 各组SpO2比较(x±s)
% 组别 SpO2 P T0 T1 A组 97.61±1.11 97.57±1.25 0.672 B组 96.34±1.01 96.11±1.06 0.127 C组 96.99±1.04 96.37±0.97 0.144 D组 97.23±1.09 96.87±1.02 0.207 P 0.576 0.642 — SpO2: 脉搏血氧饱和度。 
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表 2 患者气道压峰值比较(x±s)
cmH2O 组别 气道压峰值 A组 14.27±1.32 B组 12.07±1.68* C组 11.02±1.42* D组 10.54±1.69* 与A组比较, *P < 0.05。
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