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补髓通窍益脑汤联合靳三针治疗血管性痴呆患者的效果观察

Effect of Busui Tongqiao Yinao Decoction combined with Jin's three-needle therapy in treatment of patients with vascular dementia

    摘要
  • 摘要:
    目的 观察补髓通窍益脑汤联合靳三针对血管性痴呆患者脑血流动力学的影响。
    方法 选取2020年2月—2021年5月在三亚市中医院脑血管科门诊就诊的114例患者，随机分为研究组和对照组，每组57例。对照组口服盐酸多奈哌齐片治疗，研究组在对照组基础上口服补髓通窍益脑汤联合靳三针治疗。比较2组疗效；比较2组治疗前后中医症候积分、简易智力状态检查量表（MMSE）评分、痴呆程度分级量表（CDR）评分、日常生活能力量表（ADL）评分以及脑血流动力学指标双侧大脑中动脉（MCA）、基底动脉（BA）、前动脉（ACA）、后动脉（PCA）。
    结果 研究组治疗总有效率高于对照组，差异有统计学意义（P<0.05）；研究组治疗后善忘、智能减退、表情淡漠、腰酸腿软和头昏耳鸣的中医症候积分低于对照组，差异有统计学意义（P<0.05）；研究组治疗后MMSE评分、ADL评分高于对照组，CDR评分低于对照组，差异有统计学意义（P<0.05）；研究组治疗后MCA、BA、ACA、PCA高于对照组，差异有统计学意义（P<0.05）。
    结论 补髓通窍益脑汤联合靳三针有助于改善肾虚痰瘀证血管性痴呆患者的中医症候及脑血流动力学指标，降低痴呆程度，增强患者独立生活能力、日常生活能力，提高临床疗效。

     

    Abstract:
    Objective To observe the effect of Busui Tongqiao Yinao Decoction combined with Jin's three-needle therapy on cerebral hemodynamics in patients with vascular dementia.
    Methods A total of 114 patients in the cerebrovascular clinic of Sanya City Hospital of Traditional Chinese Medicine from February 2020 to May 2021 were selected and randomly divided into study group and control group, with 57 cases in each group. The control group was orally taken donepezil hydrochloride tablets, while the study group was treated with Busui Tongqiao Yinao Decoction and Jin's three-needle therapy on the basis of the control group. Therapeutic effect was compared between the two groups; the scores of syndromes of Traditional Chinese Medicine, the Mini-mental State Examination (MMSE), the Clinical Dementia Rating (CDR), the Activity of Daily LivingScale (ADL) and the cerebral hemodynamic indexesbilateral middle cerebral artery (MCA), basilar artery (BA), anterior artery (ACA), posterior artery (PCA) before and after treatment were compared between two groups.
    Results The total effective rate in the study group was significantly higher than that in the control group(P<0.05); the scores of syndromes of traditional Chinese medicine such as forgetfulness, loss of intelligence, indifferent expression, backache and soft legs as well as dizziness and tinnitus after treatment in the study group were significantly lower than those in the control group (P<0.05); the MMSE score and ADL score after treatment in the study group were significantly higher than those in the control group, while the CDR score was significantly lower than that in the control group (P<0.05); the MCA, BA, ACA and PCA in the study group were significantly higher than those in the control group after treatment (P<0.05).
    Conclusion Busui Tongqiao Yinao Decoction combined with Jin's three-needle therapy is helpful to improve the symptoms of traditional Chinese medicine and cerebral hemodynamic indexes in patients with vascular dementia differentiated as syndrome of kidney deficiency and phlegm stasis, reduce the degree of dementia, enhance the independent living ability and daily living ability, and increase clinical efficacy.

     

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