血清维生素D代谢物与成年女性睡眠时间的相关性分析

龚和杨子; 邢丽菲; 康毅敏; 王帆

doi:10.7619/jcmp.20221610

血清维生素D代谢物与成年女性睡眠时间的相关性分析

Relationship between serum vitamin D metabolites and sleep duration among adult women

摘要

摘要:
目的探讨成年女性血清维生素D代谢物与睡眠时间的相关性。
方法选取美国国家健康与营养调查（NHANES）数据库中20~65岁的9 353例女性为研究对象，采用液相色谱-串联质谱法定量检测25-羟基维生素D25（OH）D、25-羟基维生素D₂25（OH）D₂及25-羟基维生素D₃25（OH）D₃等血清维生素D代谢物；按照睡眠时间不同将研究对象分为睡眠不足组和非睡眠不足组。调整年龄、种族、受教育程度、婚姻状况、经济状况、体质量指数（BMI）、慢性病状况和抑郁评分后，采用Logistic回归模型结合限制性立方样条模型分析血清维生素D浓度与睡眠时间的关联性。
结果 9 353例女性研究对象中，3 189例（34.1%）女性睡眠不足，包括20~44岁女性1 627例（51.0%）和45~65岁女性1 562例（49.0%）。血清25（OH）D₃及25（OH）D每增加10 nmol/L，睡眠不足的发生率分别下降5.5%与5.7%OR=1.005 5，95%CI为1.003 6~1.007 3；OR=1.005 7，95%CI为1.003 9~1.007 6。限制性立方样条模型显示，当血清25（OH）D₃≤70 nmol/L时，睡眠时间随着血清25（OH）D₃浓度的升高而延长，呈较强的正相关；当血清25（OH）D₃>70 nmol/L时，正相关关系变弱。
结论成年女性睡眠状况与体内血清维生素D代谢物浓度存在相关性，且不同维生素D浓度的女性睡眠时间不同。当血清维生素D代谢物浓度较低时，提高维生素D代谢物的水平更有助于睡眠时间的延长。

Abstract:
Objective To explore the association between serum vitamin D metabolites and sleep duration in adult women.
Methods Women aged 20 to 65 in the National Health and Nutrition Examination Survey (NHANES) database were selected as research objects. Serum vitamin D metabolites including 25-hydroxyvitamin D25(OH)D, 25-hydroxyvitamin D₂25(OH)D₂ and 25-hydroxyvitamin D₃25(OH)D₃ were measured using ultra performance liquid chromatography-tandem mass spectrometry. The study objects were divided into sleep deficiency group and non-sleep deficiency group according to varied sleep duration. Logistic regression model and restrictive cubic spline model were used to analyze the relationship between serum vitamin D concentration and sleep condition after adjusting age, race, education level, marital status, economic status, body mass index(BMI), chronic disease status and depression score.
Results Among 9 353 females, 3 189 (34.1%) had insufficient sleep, including 1 627 (51.0%) aged 20 to 44 years and 1 562 (49.0%) aged 45 to 65 years. With an increase of 10 nmol/L of serum 25(OH)D₃ and 25(OH)D, the incidence of sleep insufficiency decreased by 5.5% and 5.7%, respectivelyOR=1.005 5, 95%CI, 1.003 6 to 1.007 3; OR=1.005 7, 95%CI, 1.003 9 to 1.007 6. The restrictive cubic spline model showed that when serum 25(OH)D₃ is ≤ 70 nmol/L, a strong positive correlation was observed between sleep duration and serum 25(OH)D₃ concentration. However, this positive correlation becomes weaker when serum 25(OH)D₃ was >70 nmol/L.
Conclusion There is an association between the sleep status and the time of serum concentration of vitamin D metabolites in adult women. The sleep duration varies at different vitamin D concentration levels. When the concentration of serum vitamin D metabolites is low, improvement of level of vitamin D metabolites is more conducive to prolongation of sleep time.

HTML全文

参考文献(30)

施引文献

资源附件(0)