Abstract: This study summarizes the holistic nursing management of high-output stomas in three cases of refractory Crohn's disease following double stoma surgery. The nursing highlights encompassed management of high-output stomas (including assessment of high stoma output, use of octreotide acetate combined with Bifidobacterium and montmorillonite powder to reduce high stoma output, and dual stoma management), dynamic assessment of nutritional risk, stepped nutritional support, psychological intervention, and continued care at home. After treatment and nursing, the high stoma output in all three patients was effectively controlled, their nutritional status gradually improved, and they were discharged in an improved condition.