Abstract: The skin, as the first line of defense in the human body, is often damaged by physical, mechanical, biological, chemical and other factors. The skin wound healing is a complex process, including the regeneration of various tissues, proliferation of granulation tissues and formation of scar tissues, and all the processes show synergism with each other. Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional cytokine that is widely expressed in various human tissues. In the process of wound healing, ANGPTL4 not only affects the process of inflammatory response, but also promotes the migration and differentiation of keratinocytes, the proliferation of endothelial cells and the reduction of the expression of scar-related collagen. Therefore, ANGPTL4 plays an important role in the inflammatory and proliferative phases of skin healing. This paper summarizes the function and mechanism of ANGPTL4 in skin wound healing.